DUCK EGGWHITE POTENTIAL IN TREATING SUBACUTE LEAD POISONING

Authors

  • Aulia Andi Mustika Department of Anatomy, Physiology and Pharmacology, Faculty of Veterinary Medicine, Bogor Agricultural University, Indonesia
  • Andriyanto Andriyanto Department of Anatomy, Physiology and Pharmacology, Faculty of Veterinary Medicine, Bogor Agricultural University, Indonesia
  • Lina Noviyanti Sutardi Department of Clinic, Reproduction and Pathology, Faculty of Veterinary Medicine, Bogor Agricultural University, Indonesia.
  • Meilisa L Margarita Department of Anatomy, Physiology and Pharmacology, Faculty of Veterinary Medicine, Bogor Agricultural University, Indonesia

DOI:

https://doi.org/10.22159/ajpcr.2017.v10s2.19499

Keywords:

Duck egg white, Lead, Potential, Subacute

Abstract

Objectives: The aim of this research is to study duck eggwhite potential in treating subacute lead poisoning.

Methods: The potential of duck egg white was evaluated from the red blood cell profile and the clinical signs that emerged. The research used thirtymale rats which were divided into 6 groups and 5 replications (i.e. rats as control, rats dministrated only with lead, rats administrated with leadand antidote). Each of the four treatment groups were given one antidote (i.e. EDTA, 50% egg white, 75% egg white, and 100% egg white). Leadforce feeding was conducted for 15 days, followed by the administration of the antidote for the same duration of 15 days, and concluded with bloodsampling at the end of each treatment.

Results: There was no significant effect on haemoglobin but lead decreased total red blood cells (p<0.05) in subacute lead poisoning. Rats that weregiven 75% and 100% duck egg white as an antidote showed an increase in total red blood cell counts in addition to a faster recovery.

Conclusion: High concentration of duck egg white had shown positive results as an antidote for subacute lead poisoning.

 

Downloads

Download data is not yet available.

References

Pokras MA, Kneeland MR. Understanding lead uptake and effects across species lines: A conservation medicine approach. Watson RT, Fuller M, Pokras M, Hunt WG, editors. Ingestion of Lead from Spent Ammunition: Implications for Wildlife and Humans. Idaho (US): The Peregrine Fund; 2009.

Mugahi MN, Heidari Z, Sagheb HM, Barbarestani M. Effects of chronic lead acetate intoxication on blood indices of male adult rat. DARU J Pharm Sci 2003;11 Suppl 4:147-51.

Verheij J, Voortman J, Nieuwkerk CM, Jarbandhan SV, Mulder CJ, Bloemena E. Hepatic morphopathologic findings of lead poisoning in a drug addict: A case report. J Gastrointestin Liver Dis 2009;18 Suppl 2:225 7.

Sears ME. Chelation: Harnessing and enhancing heavy metal detoxification. Sci World J 2013;2013(12):1-13.

Muller H, Regard S, Petriccioli N, Kherad O. Traditional medicine: A rare cause of lead poisoning in Western countries. F1000Res 2013;2:250.

Flora SJ, Mittal M, Mehta A. Heavy metal induced oxidative stress and its possible reversal by chelation therapy. Indian J Med Res 2008;128:501-23.

Flora SJ, Pachauri V. Chelation in metal intoxication. Int J Environ Res Public Health 2010;7(7):2745-88.

Mikirova N, Casciari J, Hunninghake R, Riordan N. EDTA chelation therapy in the treatment of toxic metals exposure. Spatula DD 2011;1 Suppl 2:81-9.

Hernberg S. Lead poisoning in a historical perspective. Am J Ind Med 2000;38(3):244-54.

Jalaludeen A, Churcil RR. Duck eggs and their nutritive values. Poult Line 2006;10:35-9.

Laurence DR, Bacharach AL. Evaluation of Drug Activities: Pharmacometrics. London (UK): Academic Press; 1964. p. 135-79.

Froom P, Kristal-Bonch E, Benbassat J. Lead exposure in battery-factors worker is not associated with anemia. J Occup Environ Med 1999;41:120-3.

Gam E. Bee honey dose-dependently ameliorates lead acetate-mediated hepatorenal toxicity in rats. Life Sci J 2012;9 Suppl 4:780-8.

Weiss DJ, Wardrop KJ. Schalm’s Veterinary Hematology. 6th ed. Iowa (US): Blackwell Publishing; 2010.

Suradkar SG, Ghodasara DJ, Vihol P, Patel J, Jaiswal V, Prajapati KS. Haemato-biochemical alterations induced by lead acetate toxicity in wistar rats. Vet World 2009;2 Suppl 11:429-31.

Thuppil V, Kaushik VS. Future of lead chelation-distribution and treatment. J Krishna Inst Med Sci Univ 2012;1 Suppl 1:6-23.

Shiri R, Ansari M, Ranta M, Falah-Hassani K. Lead poisoning and reccurent abdominal pain. Ind Health 2007;45 Suppl 3:494-6.

Amour M, Boshe J. Eggs: Clearing the charges, exploring the potential! Dar Es Salaam Med Stud J 2012;19:34-7.

Guitérrez M, Carías D, Cioccia AM, Hevia P. Effect of diarrhea on nutrient utilization in protein deficient or protein-calorie deficient rats. Arch Latinoam Nutr 2006;56 Suppl 1:43-50.

Mason LH, Harp JP, Han DY. Pb Neurotoxicity: Neuropsychological effects of lead toxicity. Biomed Res Int 2014;2014:1-8.

Annex XV Dossier. Proposal for Identification of a Substance as a Category 1A or 1B CMR, PBT, vPvB or a Substance of an Equivalent Level of Concern. Vol. 18. CA of the Netherlands; 2001.

Published

01-05-2017

How to Cite

Mustika, A. A., A. Andriyanto, L. N. Sutardi, and M. L. Margarita. “DUCK EGGWHITE POTENTIAL IN TREATING SUBACUTE LEAD POISONING”. Asian Journal of Pharmaceutical and Clinical Research, vol. 10, no. 14, May 2017, pp. 98-101, doi:10.22159/ajpcr.2017.v10s2.19499.

Issue

Section

Original Article(s)