@article{SHARMA_2022, title={EFFECTS OF AQUEOUS EXTRACT OF PURIFIED CURCUMA LONGA ON ANXIETY LEVELS IN SWISS ALBINO MICE}, volume={15}, url={https://journals.innovareacademics.in/index.php/ajpcr/article/view/44810}, DOI={10.22159/ajpcr.2022.v15i8.44810}, abstractNote={<p><strong>Objectives: </strong>This study was performed to see the effects of aqueous extract of purified <em>Curcuma longa </em>(CL) on anxiety levels of Swiss albino mice using open-field test.</p> <p><strong>Methods: </strong>CL at 50 mg/kg body weight (b.w) (CL50), CL at 100 mg/kg b.w. (CL100), and CL at 200 mg/kg b.w. (CL200) with negative and positive controls were used. The experimental results were represented as mean±standard deviation, p<0.05 was considered. Statistical differences between the test drug and control groups as well as within the test drug groups were calculated using Mann–Whitney <em>U</em>-test.</p> <p><strong>Results: </strong>The number of squares crossed in 5 min was least in distilled water (DW) as compared to all other groups (CL50, CL100, and CL200 [p=0.002], diazepam [p=0.002]).Time spent in the central square was lesser in the DW group than CL50 (p=0.045), CL200 (p=0.005), and DP (p=0.004). More time was spent by DP in the central square than CL50 (p=0.045) and CL100 (p=0.037) groups. The number of rearing was lesser in DW group as compared to CL50 (p=0.030), CL100 (p=0.006), and CL 200 (p=0.006) as well as DP. The number of rearing was less in CL50 than CL200 (p=0.045) group.</p> <p><strong>Conclusion: </strong>This study showed that CL possesses anxiolytic effect.</p>}, number={8}, journal={Asian Journal of Pharmaceutical and Clinical Research}, author={SHARMA, ASHISH}, year={2022}, month={Aug.}, pages={179–183} }