TY - JOUR AU - Dash, Swagatika AU - Pattanaik, Sovan AU - Rout, Sudhanshu Sekhar AU - Bose, Anindya PY - 2015/07/01 Y2 - 2024/03/29 TI - EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF THE AERIAL PARTS OF PHYLLANTHUS RETICULATES AGAINST PARACETAMOL INDUCED HEPATIC DAMAGE IN RATS JF - Asian Journal of Pharmaceutical and Clinical Research JA - Asian J Pharm Clin Res VL - 8 IS - 4 SE - Original Article(s) DO - UR - https://journals.innovareacademics.in/index.php/ajpcr/article/view/6507 SP - 221-224 AB - <p>ABSTRACT<br />Objective: The present study deals with evaluation of hepatoprotective effect against paracetamol induced hepatitis in rats and in-vitro antioxidant<br />activity of aerial parts of ethanolic extract (70%) of Phyllanthus reticulates.<br />Methods: Alteration in the levels of biochemical markers of hepatic damage like AST, ALT, ALP and total Bilirubin were tested in both treated and<br />untreated groups.<br />Results: Treatment with ethanolic extract of Phyllanthus reticulates (400 mg/kg) has brought back the altered levels of biochemical markers to the<br />near normal level which is comparable with the standard drug Silymarin.<br />Conclusion: Further the in-vitro antioxidant activity and total phenolic content showed significant result which in turn encourages further evaluation<br />of this plant in future.<br />Keywords: Phyllanthus, Hepatitis, Biochemical markers, Antioxidant activity, Total phenolic content.</p> ER -