@article{Earle_Jammu_Usha_Lingam_2018, title={COMPARISON AND CHARACTERIZATION OF INCLUSION COMPLEXES AND SOLID DISPERSIONS IN ENHANCEMENT OF DISSOLUTION RATE OF POORLY WATER SOLUBLE DRUG}, volume={10}, url={https://journals.innovareacademics.in/index.php/ijap/article/view/25054}, DOI={10.22159/ijap.2018v10i5.25054}, abstractNote={<p><strong>Objective: </strong>The purpose of the present study was to enhance solubility and dissolution characteristics of indomethacin by preparing inclusion complexes with hydroxypropyl β-cyclodextrin (HP β-CD) and solid dispersions with PEG 6000 to enhance its <em>in vitro</em> drug release and to further formulate it as a tablet</p><p><strong>Methods: </strong>Solid dispersions (SDs) and inclusion complexes (ICs) of Indomethacin with PEG 6000 and HP β-CD respectively were prepared to enhance the dissolution rate of this poorly water-soluble drug belonging to BCS class II. A comparison was made between two systems: solid dispersions with PEG 6000 obtained using melting and solvent evaporation technique, inclusion complexes with HP β-CD prepared by kneading technique. SDs were prepared in 1:1, 1:2, 1:3 and ICs in 1:0.25, 1:0.5, 1:1 w/w ratios of drug: polymer. Both the systems were characterized by FTIR, SEM, DSC, X-RD.</p><p><strong>Results: </strong>The dissolution of indomethacin increased with the increase in the concentration of the polymers. F4 and F9 formulations showed complete drug release in less than 30 min. Dissolution studies indicated that cyclodextrin complexes showed a better enhancement of dissolution rate when compared to solid dispersions. CDs were found to be more effective than PEGs at lower concentrations. These formulations were further compressed as tablets.</p><p><strong>Conclusion: </strong>The FTIR and DSC studies showed that no interactions existed between the drug and the polymer.</p>}, number={5}, journal={International Journal of Applied Pharmaceutics}, author={Earle, Radha Rani and Jammu, Rambabu and Usha, Lakshmi and Lingam, Ratna Kanth}, year={2018}, month={Sep.}, pages={173–177} }