Innovare Journal of Medical Sciences

AZITHROMYCIN-INDUCED HYPERSENSITIVITY AND COVID-19: A CASE REPORT

2024-03-24T11:22:06+0530

An adverse drug reaction is called drug hypersensitivity syndrome. However, experts regard macrolide allergies to be infrequent. Moreover, this group of antibiotics is considered relatively safe. Although azithromycin is prescribed in COVID-19 patients due to the positive observed effects, hypersensitivity syndrome from this agent has rarely been reported. The case study discusses a 30-year-old man, who was diagnosed with coronavirus disease 2019 and exhibited fever (39.1°C), diffuse maculopapular rash, shortness of breath, wheezing, swelling, itching, pain, subconjunctival hemorrhage, eosinophilia (8.9% of 10.2×103/μL leukocytes), and elevated aminotransferase level following treatment with azithromycin. The Naranjo algorithm classified this case in the “definite” category. Therefore, due to the high prevalence of COVID-19 and increased administration of azithromycin, physicians should be made aware of the potential for unusual toxicity associated with azithromycin, which may become more prevalent as its use continues to expand in the future.

ANAPHYLACTIC DEATH CAUSED BY LIVER HYDATID CYST RELYING ON THE IMPORTANCE OF AUTOPSY – A CASE REPORT

2024-05-24T01:29:41+0530

Hydatid cyst is a common disease between humans and dogs as the main host and sheep as the intermediate host with the parasitic agent Echinococcus. There have been reports of hydatid cyst rupture spontaneously or following trauma. Autopsy, as the best way to determine the cause of death, can be the witness of the occurrence of a crime or an event. In the current study, a child death, that occurred as a result of a collision with another child at school, was investigated after his father complained to the school principal, and an autopsy was performed by forensic medicine. In forensic reports, the cause of death was anaphylactic shock due to a cyst in the right lobe of the liver. According to the pathology report, the cause of the liver cyst was a parasitic infection of Echinococcus granulosus.

A REVIEW ON USE OF ULTRAVIOLET SPECTROSCOPY

2024-05-18T19:41:45+0530

One significant and cutting-edge analytical tool employed in the pharmaceutical business over the past three decades is ultraviolet (UV) spectroscopy. The analytical technique measures the amount of monochromatic light absorbed by colorless substances in the near UV (200–400 nm) range. The processes required to ascertain the “identity, strength, quality, and purity” of such chemicals are included in the pharmaceutical analysis. It also covers the examination of raw materials and intermediates used in the pharmaceutical production process. A spectrophotometer covering the UV range operates on the basic principle of light passing through a solvent-filled cell and onto a photoelectric cell, which converts radiant energy into electrical energy that can be detected by a galvanometer. To determine the absorbance spectrum of a substance in solution or as a solid, UV -visible spectroscopy is utilized. The purpose of this review is to present details about the following topics: Q-absorbance quantitative relation methodology, twin wavelength methodology, absorptiontivity methodology, multivariate chemometrics, distinction spectrophotometry, by-product spectrophotometry, absorbance quantitative relation spectra, by-product quantitative relation spectra, successive quantitative relation by-product spectra, and absorption factor, and physical property factor methodology.