International Journal of Pharmacy and Pharmaceutical Sciences <div align="justify"> <div align="justify"> <p>International Journal of Pharmacy and Pharmaceutical Sciences (Int J Pharm Pharm Sci) is a monthly (April 2014 onwards) peer-reviewed, open access journal. IJPPS publishes original research work in the form of original articles or short communications, which contribute significantly to advance scientific knowledge in pharmacy and pharmaceutical sciences. Review articles on the current and trending subject are also considered by the journal provided they match the current research needs and possess scientific impact.</p> <p>The Scope of the journal encompasses the following</p> <ul> <li class="show">Pharmaceutical Technology, Pharmaceutics, Novel Drug Delivery, Biopharmaceutics, Pharmacokinetics</li> <li class="show">Pharmacognosy and Natural Product Research</li> <li class="show">Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis</li> <li class="show">Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy</li> <li class="show">Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Pharmacoeconomics</li> </ul> <p>Research outcomes from medical science/case study and biotechnology of pharmaceutical interest are also considered. From March 2016 journal has also started considering hypothesis however the frequency is limited.</p> <p>IJPPS is committed to bring on surface the diligent and hard work of researchers for the betterment of science and society.</p> <br><br></div> </div> Innovare Academic Sciences Pvt Ltd en-US International Journal of Pharmacy and Pharmaceutical Sciences 2656-0097 GENERATION-DEPENDENT TARGETING POTENTIAL OF DONEPEZIL-LOADED POLY (PROPYLENE IMINE) DENDRIMER THROUGH GOAT NASAL MUCOSA <p><strong>Objective: </strong>In the domain of nano drug delivery, dendrimers are the most explored bioactive polymeric carrier system. The present work was aimed to study the diffusion potential of different generations of Poly(propyleneimine) (PPI) dendrimers on goat nasal mucosa in an <em>ex vivo </em>study and synthesize a stable dendrimer for olfactory drug delivery.</p> <p><strong>Methods: </strong>The generations (3.0G, 4.0G, and 5.0G) of PPI dendrimer were synthesized and PEGylated by MPEG 5000 and then loaded with donepezil. A comparative study was carried out among all generations in terms of their drug loading capacity, stabili.ty, sustained release behavior as well as for targeting efficacy. An <em>ex</em>-<em>vivo</em> study was carried out on Franz Diffusion Cell with goat nasal mucosa.</p> <p><strong>Results: </strong>The developed G3, G4, and G5 dendrimer formulations had entrapment efficiency of 24.33±0.56%, 40.12±0.62%, and 60.4±0.6%, respectively. The nasal diffusion study revealed that 5.0G PPI dendrimer increased diffusion of donepezil up to 47% as compared to the pure solution of donepezil, while 10% improvement in diffusion was seen as compared to 4.0 G PPI dendrimer. Thus obtained results claimed that the drug loading as well as targeting potential of PPI dendrimers increased with the increase in the number of generations. The investigation outcome indicated promising results of 5.0G PPI dendrimer over the 3.0G and 4.0G PPI dendrimer generations for their drug loading capacity, stability, and sustained release action.</p> <p><strong>Conclusion: </strong>The 5.0G PPI dendrimer proved its superior candidature over the other lower generations of PPI dendrimers for drug delivery and drug targeting.</p> NITIN DWIVEDI BALAK DAS KURMI PRASHANT KESHARWANI JIGNA SHAH Copyright (c) 2023 NITIN DWIVEDI, BALAK DAS KURMI, PRASHANT KESHARWANI, JIGNA SHAH 2023-05-01 2023-05-01 38 39 EFFECT OF COOKING METHODS ON TOTAL PHENOLICS AND ANTIOXIDANT ACTIVITY OF SELECTED WILD EDIBLE PLANTS <p><strong>Objective:</strong> The target of this appraisal was to explore the impacts of various cooking techniques, for example, boiling and microwave cooking on total phenolics and antioxidant activity of <em>Zanthoxylum acanthopodium</em>, <em>Viburnum foetidum</em>, <em>Houttuynia cordata</em>, <em>Sonchus arvensis</em> and <em>Oenanthe linearis</em>, widely consumed by the common individuals of the North-Eastern area of India. </p> <p><strong>Methods:</strong> The antioxidant activities of the plants were determined by using 1,1-diphenyl-2-picryl hydrazyl (DPPH) radical scavenging activity, ABTS radical scavenging ability, reducing power capacity, estimation of total phenolic content, flavonoid content and flavonol content.</p> <p><strong>Results:</strong> Total phenolics content (TPC) of fresh vegetables ranged from 108.28 to 253.99 mg/100 g (as gallic acid equivalent) on a dry weight basis. Total antioxidant capacity of fresh plants (IC<sub>50</sub> mg dry extract) determined by DPPH and ABTS ranged from 0.37-1.23 and 0.29-0.89 respectively. Boiling caused the highest losses of TPC, resulting in a reduction of the TPC on dry weight (DW) basis ranging from 9.37% in <em>O. linearis</em> up to 25.97% in <em>Z. acanthopodium</em> whereas microwave cooking enhanced TPC ranging from 4.09% to 10.38%. Similarly, boiling treatment decreased the DPPH radical scavenging activities ranging from 10.65 to 29.77% and ABTS radical scavenging activities ranging from 5.88-16.35%, whereas microwave cooking increased the DPPH and ABTS radical scavenging activities ranging from 8.02-24.20% and 9.86 to 19.70% respectively, in the studied plants.</p> <p><strong>Conclusion:</strong> The results suggest that the best cooking method for increasing the concentration of polyphenols and antioxidants was microwave cooking, while boiling was the least recommended method.</p> TAPAN SEAL BASUNDHARA PILLAI KAUSIK CHAUDHURI Copyright (c) 2023 TAPAN SEAL, BASUNDHARA PILLAI, KAUSIK CHAUDHURI 2023-05-29 2023-05-29 10.22159/ijpps.2023v15i7.48179 ANATOMICAL-HISTOLOGICAL STUDY OF SOME PLANTS USED IN THE TREATMENT OF BILHARZIA IN COTE D'IVOIRE <p><strong>Objective: </strong>The study of 11 plants used in the treatment of Bilharzia in Côte d'Ivoire aims to highlight their anatomical-histological structures.</p> <p><strong>Methods: </strong>The anatomical study of these plants was carried out on the stems by the classical method of staining the tissues with carmine-green.</p> <p><strong>Results: </strong>This staining technique made it possible to distinguish two groups of tissues. Those with a pink stained cell wall (cellulose wall cells) and those with a green stained lignified cell wall. From the periphery to the interior of the organs, we observe the epidermal hairs, the epidermis, the collenchyma, the cortical parenchyma, the sclerenchyma (for aged or more or less aged tissues), the liber or phloem, the wood or xylem and the medullary parenchyma.</p> <p><strong>Conclusion: </strong>The carmine-green staining made it possible to distinguish different plant stem tissues, arranged according to the colouring, structure, shape and size of the cells in each tissue.</p> KOUADIO BENE ALAIN AZOKOU KOUASSI BERNADIN KOUAME Copyright (c) 2023 KOUADIO BENE, ALAIN AZOKOU, KOUASSI BERNADIN KOUAME 2023-06-01 2023-06-01 24 28 10.22159/ijpps.2023v15i6.48087