FORMULATION AND EVALUATION OF GASTRORETENTIVE TABLETS OF ANTIULCER DRUG

VISHAL YADAV; PRAKASH JADHAV; Pranali Salunkhe; PRITI NIKAM; SHITAL MATKAR

doi:10.22159/ajpcr.2016.v9i6.10360

Authors

VISHAL YADAV
PRAKASH JADHAV
Pranali Salunkhe shivaji university
PRITI NIKAM
SHITAL MATKAR

DOI:

https://doi.org/10.22159/ajpcr.2016.v9i6.10360

Abstract

ABSTRACT

Gastroretentive floating drug delivery system is utilised to target drug release in the stomach or to the upper part of intestine. Lansoprazole is proton pump inhibitor intended for oral administration used as antiulcer agent. The present investigation involved formulation and evaluation of Gastroretentive floating tablets of Lansoprazole for prolongation of gastric residence time with a view to deliver the drug at sustained and controlled manner in gastrointestinal tract. The tablets of Lansoprazole were prepared by direct compression method using gas generating agent and different polymer combinations (HPMCK4M, HPMC K100M, Psyllium husk) . The prepared tablets of Lansoprazole were evaluated for hardness, thickness, friability, weight variation, drug content uniformity, buoyancy lag time, total floating time, swelling index, in-vitro dissolution study. The varying concentration of gas generating agent and polymers were found to affect on in-vitro drug release, floating lag time and swelling index. In vitro drug release of floating Gastroretentive tablet of Lansoprazole shown that the formulation F2 was found to be the best formulation as it releases 97.9% Lansoprazole in a controlled manner for extended period of time (upto 12 hrs.)

Keywords: Lansoprazole, Gastroretentive, floating tablet, total floating time.

Downloads

Download data is not yet available.

Author Biography

Pranali Salunkhe, shivaji university

pharmaceutics department

References

Chein YW. Novel Drug Delivery Systems. 2nd ed. New York: Marcel Dekker Inc.; 1992. p. 139-1.

Singh BN, Kim KH. Floating drug delivery systems: An approach to oral controlled drug delivery via gastric retention. J Control Release 2000;63:235-59.

Brahmankar DM, Jaiswal SB. Biopharmaceutics and Pharmacokinetics a treatise. Reprint of 1st ed. New Delhi: Vallabh Prakashan, Jain MK; 2003. p. 371-35.

Thomas WL, Robinson JR. In: Gennaro AR, editor. Remington: The Science and Practice of Pharmacy. 20th ed. Vol. I. Philadelphia, PA: Lippincott Williams and Wilkins; 2000. p. 929-03.

Pahwa R, Lamba A. Formulation and in-vitro evaluation of effervescent floating tablets of an antiulcer agent. JCPR 2012;4(2):1073-61.

More HN, Hajare AA. Practical Physical Pharmacy. 2nd ed. Nasik; Career Publications; 2010. p. 126.

Aulton ME. The Design and Manufacture of Medicines. 3rd ed. Edinburgh: Churchill Living Stone Elsevier; 2008. p. 356.

Shah SH. Formulation and evaluation of effervescent floating tablet of levofloxacin against H. Pylori infection. Pelagia research library. Der Pharm Sin 2010;1(3):244-32.

Gupta AK. Introduction to Pharmaceutics-I. 3rd ed. New Delhi: CBS Publication; 2006. p. 270-68.

Patel R. Formulation and optimization of floating matrix tablet of ranitidine hydrochloride. IJCP 2011;5(8):5-1.

Indian Pharmacopoeia. Ministry of Health and Family Welfare. 4th ed., Vol. 1. New Delhi: Government of India. Pharmacopoeia of India, Controller of Publication; 2007. p. 183-2.

Kumar GG, Garuji R, Reddy CK. Formulation and evaluation of omeprazole gastroretentive floating tablets based on hydrophilic polymers. JPCBS 2012;1(1):9-6.

Raval JA. Formulation of floating mixed matrix tablets using low density copolymer. IRJP 2011;1(1):7-1.

Gaikwad VD. Development of floating drug delivery system for 5-fluorouracil. Invent Rapid 2013;2:4-1.

Keerthi K, Veerabhadraiah BB, Srinivasan B, Rajamanickam D, Varadharajan M. Formulation and evaluation of effervescent gastroretentive drug delivery system of Lansoprazole. Invent Impact Pharm Tech 2012;2:120-15.

Gaikwad VD, Yadav VD, Jadhav PD. Formulation and evaluation of floating matrix tablets of diltiazem HCL. Asian J Pharm 2012;6(4):251-45.

Babu GD, Chandra SR, Devi AS, Reddy BV, Latha NS. Formulation and evaluation of novel effervescent metronidazole floating tablets. Int J Res Pharm Biomed Sci 2011;2(4):1662-57.

Charyulu NR. Effect of combination of HPMC and carbopol 934 p on

the properties of the gastric floating tablets timolol malate. J Drug Deliv Ther 2013;3(4):20-5.

The United State Pharmacopoeia. 27th Revision and the National Formulary. 22nd ed. The Official Compendia of Standards, Asian Edition the Board of Trustees; 2004. p. 2304-3.

Bhise SB, Dias RJ. Laboratory Manual of Biopharmaceutics and Pharmacokinetics. Satara: Thrinity Publishing House; 2010. p. 21.

Sarangapani S, Rajappan M. Lansoprazole release from a floating dosage form based on the natural polymer of Delonix regia. IJPRIF 2012;4(3):1095-84.