REVIEW ON ETHNOBOTANICAL STUDIES OF NUTRACEUTICAL PLANT: CAPPARIS SPINOSA L. (CAPER)

Authors

  • Manikandaselvi S PG and Research Department of Biochemistry, SengamalaThayaar Educational Trust Women’s College, Mannargudi, Tamilnadu, India.
  • Vadivel V Center for Advanced Research in Indian System of MedicineSASTRA UniversityThanjavur, Tamilnadu, India
  • Brindha P Centre for Advanced Research in Indian System of Medicine, SASTRA University, Thanjavur, Tamilnadu, India

Abstract

Objective: Capparis spinosa L. (Caper) is a perennial spiny bush that bears rounded, fleshy leaves and big white to pinkish-white flowers. It is native
to the Mediterranean region and growing wild on walls or in rocky coastal areas throughout India. Even though it has been used in traditional Indian
system of medicines for various human diseases, the summation of its medicinal properties is lacking. Hence, the present review focused to provide
collective information regarding the medicinal value of C. spinosa.
Methods: Literatures were collected from online resources like Scopus, Sciencedirect etc., related to the pharmacological activities of Capparis spinosa
and the available information were summarized and given in the review.
Results: C. spinosa has anthelminthic, cytotoxic, anti-inflammatory, antiarthritic, antioxidant, antibacterial, antifungal, antiviral, cardiovascular,
chondroprotective, antidiabetic, hypolipidemic, antiallergic and antihistaminic, immunomodulatory, anticarcinogenic, and antihepatotoxic activity.
The phytochemicals identified in this plant were lipids, alkaloids, glucocapperin, and polyphenols.
Conclusion: This review attempts to encompass the available literature on C. spinosa with respect to its pharmacognostic characters, chemical
constituents, nutritional characters, various pharmacological activities, traditional uses, and modern use.
Keywords: Capparis spinosa L., Caper, Medicinal properties, Nutritional value, Phytochemicals.

Downloads

Download data is not yet available.

References

REFERENCES

Jarvis CE, Barrie R, Allan DM, Reveal JL. A List of Linnaean Generic

Names and Their Types. Konigstein: Koeltz; 1993. p. 127.

Anonymous. Asphodelus tenui folius cavan. A Guide to Medicinal

Plants in North Africa. Vol. 15. Malaga, Spain: ICUN; 2005. p. 70-4.

Manikandaselvi S, Brindha P. Chemical standardization studies on

Capparis spinosa L. Int J Pharm Pharm Sci 2014;6(1):47-54.

Jagannath R. Phytochemical and Pharmacological Screening on Roots

of Capparis spinosa L (Capparidaceae). MSc Thesis. Gulbarga: HKES

College of Pharmacy; 2010.

Anonymous. The Ayurvedic Pharmacopoeia of India. Part-1. 1

ed.,

Vol. V. Kottakkal: Arya Vaidya sala; 1999. p. 41.

Zhou H, Jian R, Kang J, Huang X, Li Y, Zhuang C, et al. Antiinflammatory

effects

of caper (Capparis

spinosa

L.) fruit aqueous

extract

and

the isolation of main phytochemicals.

J

Agric

Food Chem

;58(24):12717-21.

Zhou HF, Xie C, Jian R, Kang J, Li Y, Zhuang CL, et al. Biflavonoids

from caper (Capparis spinosa L.) fruits and their effects in inhibiting

NF-kappa B activation. J Agric Food Chem 2011;59(7):3060-5.

Khanfar MA, Sabri SS, Zarga MH, Zeller KP. The chemical constituents

of Capparis spinosa of Jordanian origin. Nat Prod Res 2003;17(1):9-14.

Bhoyar MS. Molecular and phytochemical characterization and

optimization of dormancy breaking treatments in C. spinosa L from the

Himalayan region of Ladakh India. MSc Thesis, University of Jaypee;

Yang T, Wang C, Liu H, Chou G, Cheng X, Wang Z. A new antioxidant

compound from Capparis spinosa. Pharm Biol 2010;48(5):589-94.

Calis I, Kuruüzüm-Uz A, Lorenzetto PA, Rüedi P. (6S)-Hydroxy-3-oxoalpha-ionol

glucosides

from

Capparis

spinosa

fruits.

Phytochemistry

;59(4):451-7.

Feng X, Lu J, Xin H, Zhang L, Wang Y, Tang K. Anti-arthritic active

fraction of Capparis spinosa L. fruits and its chemical constituents.

Yakugaku Zasshi 2011;131(3):423-9.

Yu Y, Gao H, Tang Z, Song X, Wu L. Several phenolic acids from the

fruit of C. spinosa. Asian J Trad Med 2006;1(3):1-4.

Aliyazicioglu R, Eyupoglu OE, Sahin H, Yildiz O, Baltas N. Phenolic

components, antioxidant activity, and mineral analysis of Capparis

spinosa L. Afr J Biotechnol 2013;12(47):6643-9.

Sher H, Alyemeni MN. Ethnobotanical and pharmaceutical evaluation

of Capparis spinosa L, validity of local folk and Unani system of

medicine. J Med Plant Res 2010;4(17):1751-6.

Shayeb A. Chemical composition of essential oil and crude extract

fractions and their antibacterial activities of Capparis spinosa L. and

Capparis cartilaginea Decne. From Jordan. MSc Thesis, Yarmouk

University, Faculty of Science; 2012.

Lam SK, Han QF, Ng TB. Isolation and characterization of a lectin with

potentially exploitable activities from caper (Capparis spinosa) seeds.

Biosci Rep 2009;29(5):293-9.

Haciseferogullari H, Ozcan MM, Duman E. Biochemical and

technological properties of seeds and oils of C. spinosa and C. ovata

plants growing wild in Turkey. Food Process Technol 2011;2(6):129-34.

Tlili N, Nasri N, Saadaoui E, Khaldi A, Triki S. Sterol composition of

caper (Capparis spinosa) seeds. Afr J Biotechnol 2010;9(22):3328-33.

Al-Snafi AE. The chemical constituents and pharmacological

effects of Capparis spinosa - An overview. Indian J Pharm Sci Res

;5(2):93-100.

Qasem JR, Prospects of wild medicinal and industrial plants of saline

habitats in the Jordan valley. Pak J Bot 2015;47(2):551-70.

Rajkumar MH, Sringeswara AN, Rajanna MD. Ex-situ conservation

of medicinal plants at university of agricultural sciences, Bangalore at

Karnataka. Rec Res Sci Technol 2011;3(4):21-7.

Boulos L. Medicinal Plants of North Africa. Algonac, Michigan:

Reference Publications, Inc.; 1983. p. 286.

Yang T, Liu YQ, Wang CH, Wang ZT. Advances on investigation

of chemical constituents, pharmacological activities and clinical

applications of Capparis spinosa. China J Chin Mat Med

;33(21):2453-8.

Rivera S, Inocencio C, Obon C, Alcaraz F. Review of food and

medicinal uses of Capparis L. Subgenus Capparis (Capparidaceae).

Econ Bot 2003;57(4):515-34.

Chopra RN, Chopra IC, Handa KL, Kapur LD. Indigenous Drugs of

India. Calcutta, UN: Dhar and Sons Pvt Ltd.; 1950.

Afsharypuor S, Jeiran K, Jazy AA. First investigation of the flavour

profiles of leaf, ripe fruit and root of Capparis spinosa var. mucronifolia

from Iran. Pharm Acta Helvetiae 1989;72:307-9.

Kirtikar KR, Basu BD. Indian Medicinal Plants. Vol. 1. Allahabad: Lalit

Mohan Publication; 1993. p. 197-8.

Cooremans B. An unexpected discovery in Medieval Bruges (Flanders,

Belgium): Seeds of the caper (Capparis spinosa L). Environ Archaeol

;4:97-101.

Jiang HE, Li X, Ferguson DK, Wang YF, Liu CJ, Li CS. The discovery of

Capparis spinosa L. (Capparidaceae) in the Yanghai Tombs (2800 years

st

Asian J Pharm Clin Res, Vol 9, Issue 3, 2016, 123-126

Manikandaselvi et al.

b.p.), NW China, and its medicinal implications. J Ethnopharmacol

;113(3):409-20.

Huseini HF, Alavian SM, Heshmat R, Heydari MR, Abolmaali K. The

efficacy of Liv-52 on liver cirrhotic patients: A randomized, doubleblind,

placebo-controlled first approach 2005;12(9):619-24.

Mustafa FA. In vitro evaluation of C. spinosa against L. terrestris

(Annelida). PUJ 2011;5(2):199-202.

Sultan AO, Celik TA. Genotoxic and antimutagenic effects of

C. spinosa L. on the A. cepa L. root tip meristem cells. Caryologia

;62(2):114-23.

Tlili N, Elfalleh W, Saadaoui E, Khaldi A, Triki S, Nasri N. The

caper (Capparis L.): Ethnopharmacology, phytochemical and

pharmacological properties. Fitoterapia 2011;82:93-101.

Al-Daraji MN. A study of the inhibitory effect of the caper aqueous

crude leaf extract on the HEP-2 and HELA cancer cell line. Iraqi J

Desert Stud 2010;2(1):67-73.

Luecha P, Umehara K, Miyase T, Noguchi H. Antiestrogenic

constituents of the Thai medicinal plants Capparis flavicans and Vitex

glabrata. J Nat Prod 2009;72(11):1954-9.

Rathee P, Rathee D, Rathee D, Rathee S. In vitro anticancer activity

of stachydrine isolated from Capparis decidua on prostate cancer cell

lines. Nat Prod Res 2012;26(18):1737-40.

Venugopal Y, Ravindranth A, Kalpana G, Prabhakar PR. Anti-tumor

activity of C. sepiaria on Ehrlich ascites carcinoma in mice. Int J

Biomed Res 2011;22:262-71.

Yu L, Xie LQ, Ji YB. Preliminary study on apoptotic effect induced by

n-butanol extract in Capparis spinosa L. On SGC-7901. 4

International

Conference on Bioinformatics and Biomedical Engineering (iCBBE);

p. 18-20.

th

Al-Asady AA, Khalil KH, Barwari SS. Cytotoxic and cytogenetics

effects of aqueous, methanolic and secondary metabolites extracts of

C. spinosa on tumor cell lines in vitro. Jordan J Biol Sci 2012;5(1):15-30.

Ageel AM, Parmar NS, Mossa JS, Al-Yahya MA, Al-Said MS, Tariq M.

Anti-inflammatory activity of some Saudi Arabian medicinal plants.

Agents Actions 1986;17(3-4):383-4.

Al-Said MS, Abdelsattar EA, Khalifa SI, El-Feraly FS. Isolation and

identification of an anti-inflammatory principle from Capparis spinosa.

Pharmazie 1988;43(9):640-1.

Alsabri SG, Zetrini AE, Ermeli NB, Mohamed SB, Bensaber SM,

Hermann A, et al. Study of eight medicinal plants for antioxidant

activities. J Chem Pharm Res 2012;4(8):4028-31.

Bhoyar MS, Mishra GP, Naik PK, Srivastava RB. Estimation

of antioxidant activity and total phenolics among natural populations

of Caper (Capparis spinosa) leaves collected from cold arid desert of

trans-Himalayas. Aust J Crop Sci 2011;5:912-9.

Muhaidat R, Al-Qudah MA, Al-Shayeb A, Jacob JH, Al-Jaber HI,

Hussein E, et al. Chemical profile and antibacterial activity of crude

fractions and essential oils of Capparis ovata Desf. and Capparis

spinosa L. (Capparaceae). Int J Integr Biol 2013;14(1):39-47.

Mahasneh AM. Screening of some indigenous Qatari medicinal plants

for antimicrobial activity. Phytother Res 2002;16(8):751-3.

Mahasneh AM, Abbas JA, El-Oqlah AA. Antimicrobial activity of

extracts of herbal plants used in the traditional medicine of Bahrain.

Phytother Res 1996;10(3):251-3.

Askar AA. In vitro antifungal activity of three Saudi plant extracts

against some phytopathogenic fungi. J Plant Res 2012;2(4):458-62.

Arena A, Bisignano G, Pavone B, Tomaino A, Bonina FP, Saija A, et al.

Antiviral and immunomodulatory effect of a lyophilized extract of

Capparis spinosa L. buds. Phytother Res 2008;22(3):313-7.

Zeggwagh NA, Michel JB, Eddouks M. Cardiovascular effect of

C. spinosa aqueous extract. Part VI: In vitro vasorelaxant effect. Am J

Pharmacol Toxicol 2007;2(3):135-9.

Benzidane N, Imane K, Abderrahmane B, Noureddine C, Seddik

K, Xavier N, et al. In vitro vasomotor effects of Capparis spinosa

aqueous extracts. The 3

International Symposium on the Medicinal

Plants, Their Cultuvation and Aspects of Uses, Petra, Jordan; 2012. p.

-4.

rd

Lekhmici A, Benzidane N, Imane K, Noureddine C, Seddik K,

Abderrahmane B. Comparison between polyphenol contents and

antioxidant activities of different parts of Capparis spinosa L.

International Symposium on the Medicinal Plants, Their Cultuvation

and Aspects of Uses, Petra, Jordan; 2012. p. 61-3.

rd

Benzidane N, Charef N, Krache I, Baghiani A, Arrar L. In vitro broncho

relaxant effects of Capparis spinosa aqueous extracts on rat trachea.

J Appl Pharm Sci 2013;3(9):85-8.

Panico AM, Cardile V, Garufi F, Puglia C, Bonina F, Ronsisvalle G.

Protective effect of Capparis spinosa on chondrocytes. Life Sci

;77(20):2479-88.

Mishra PR. Antidiabetic activity of Capparis spinosa fruit extract. Int J

Pharm Sci Rev Res 2012;14(1):38-43.

Mohammadi J, Mirzaei A, Delaviz H, Mohammadi B. Effects of

hydroalcoholic extract of Capparis spinosa on histomorphological

changes of pancreas in diabetic rat model. J Birjand Univ Med Sci

;19(3):235-44.

Eddouks M, Lemhadri A, Zeggwagh NA, Michel JB. Potent

hypoglycaemic activity of the aqueous extract of Chamaemelum nobile

in normal and streptozotocin-induced diabetic rats. Diabetes Res Clin

Pract 2005;67(3):189-95.

Trombetta D, Occhiuto F, Perri D, Puglia C, Santagati NA,

De Pasquale A, et al. Antiallergic and antihistaminic effect of two

extracts of Capparis spinosa L. flowering buds. Phytother Res

;19(1):29-33.

Kulisic-Bilusic T, Schmöller I, Schnäbele K, Siracusa L, Ruberto G.

The anticarcinogenic potential of essential oil and aqueous infusion

from caper (Capparis spinosa L.). Food Chem 2012;132:261-7.

Behnaz M, Asli E, Davood S, Atena A. Quantitative analysis of

quercetin in different parts of Capparis spinosa by HPLC. Ann Biol

Res 2012;3(12):5775-8.

Argentieri M, Macchia F, Fanizzi FP, Avato P. Bioactive compounds from

Capparis spinosa subsp. Rupestris. Ind Crop Prod 2012;36(1):65-9.

Aghel N, Rashidi I, Mombeini A. Hepatoprotective activity of Capparis

spinosa root bark against CCl4 induced hepatic damage in mice. Iran J

Pharm Res 2007;6(4):285-90.

Alnuaimy RJ, Al-Khan HI. Effect of aqueous extract of Capparis

spinosa on biochemical and histological changes in paracetamolinduced

liver damage in rats. Iraqi J Vet

Sci 2012;26(1):1-10.

Fici S. Intraspecific variation and evolutionary trends in Capparis

spinosa L. (Capparaceae). Plant Syst Evol 2001;228(3):123-41.

Published

01-05-2016

How to Cite

S, M., V. V, and B. P. “REVIEW ON ETHNOBOTANICAL STUDIES OF NUTRACEUTICAL PLANT: CAPPARIS SPINOSA L. (CAPER)”. Asian Journal of Pharmaceutical and Clinical Research, vol. 9, no. 3, May 2016, pp. 123-6, https://journals.innovareacademics.in/index.php/ajpcr/article/view/10448.

Issue

Section

Original Article(s)