COMPARATIVE EVALUATION OF FEW MARKETED PRODUCTS OF AMOXICILLIN TRIHYDRATE DISPERSIBLE TABLETS IP

Abstract

Objective:  The objective of the study was to carry out the disintegration test and test for uniformity of dispersion for few marketed brands of Amoxicillin Trihydrate 250 mg dispersible tablets IP.

 

Methods: Five different brands were randomly selected for this study, which were coded as brands A, brand B, brand C, brand D and brand E. The tests for disintegration time and uniformity of dispersion were performed as per procedure stated in British Pharmacopoeia (BP 2011) and Indian Pharmacopoeia (IP 2007).

 

Results: The important criteria for dispersible tablet to comply with regulatory requirements are to pass in the disintegration test and test for uniformity of dispersion. Based on the study, all the selected brands passed the disintegration test. However among the five brands only brands B & D passed for test for uniformity of dispersion, whereas rest of brands i.e., A, C & E did not comply as per pharmacopoeial specifications.

 

Conclusion: Based on the supporting data, brand D was found to be the best and superior among the selected brands of Amoxicillin Trihydrate 250 mg dispersible tablets.

 

KEYWORDS

Dispersible Tablets, Amoxicillin Trihydrate, Disintegration Test and Uniformity of Dispersion.