SCREENING OF COMMON SIDDHA FORMULATIONS FOR ANTIMICROBIAL ACTIVITY AGAINST RESPIRATORY PATHOGENS
Abstract
ABSTRACT
Objective: The objective of this study was to screen the antimicrobial potential and minimal inhibitory concentrations (MICs) of selected commonly
used Siddha formulations against respiratory pathogens.
Methods: The most frequently and clinically used Siddha formulations for respiratory infections, namely Gowri chinthamani (R1), Sivanar amirtham
(R2), Poorana chandrodayam (R3), Thalaga parpam (R4), Pavala parpam (R5), and Vasantha kusumasura mathirai (R6) were screened for antimicrobial
activity against microbial type culture collection strains of Neisseria mucosa, Klebsiella pneumonia, Streptococcus pneumonia, Staphylococcus aureus,
Pseudomonas aeruginosa, and Aspergillus niger, respectively, by agar well diffusion method. Tetracycline and fluconozole were used as positive control
for bacterial and fungal pathogens, respectively. The zone of inhibition and the MICs were determined.
Results: Among these formulations, Sivanar amirtham (R2) and Pavala parpam (R5) showed microbial sensitivity against all the above tested
respiratory pathogens. The drug Sivanar amirtham (R2) showed higher zone of inhibition when compared to the control tetracycline.
Conclusion: The study, therefore, supports the clinical claims of Siddha formulations to have potent antimicrobial activity and offer profound
therapeutic benefits in respiratory infections.
Keywords: Siddha, Sivanaramirtham, Pavala parpam, Antibacterial activity, Antifungal activity, Respiratory infections.
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REFERENCES
Balajee K. Acute respiratory infection among under 5 children in India:
A situational analysis. J Nat Sci Biol Med 2014;5(1):15-20.
NICE Clinical Guidelines. CGNO 69. Respiratory Tract Infection-
Antibiotic Prescribing. National Institute for Health and Clinical
Excellence; 2008.
Spellberg B, Guidos R, Gilbert D, Bradley J, Boucher HW, Scheld WM,
et al. The epidemic of antibiotic-resistant infections A call to action
for the medical community from the Infectious Diseases Society of
America. Clin Infect Dis 2008;46(2)155-64.
Chopra I, Hesse L, O’Neill A. Discovery and development of new antibacterial
drugs.
In: van
der Goot H, editor.
Pharmacochemistry Library.
Trends
in Drug Research. III
ed., Vol. 32. Amsterdam: Elsevier; 2002.
p. 213-25.
rd
Khan R, Islam B, Akram M, Shakil S, Ahmad A, Ali SM, et al.
Antimicrobial activity of five herbal extracts against multi drug resistant
(MDR) strains of bacteria and fungus of clinical origin. Molecules
;14(5)586-97.
Aminov RI. A brief history of the antibiotic era lessons learned and
challenges for the future. Front Microbiol 2010;1134.
Hassan SW, Umar RA, Lawal M, Bilbis LS, Muhammad BY, Dabai YU,
et al. Evaluation of antibacterial activity and phytochemical analysis of
root extract of Boscia angustifolia. Afr J Biotechnol 2006;5(18)602-7.
Yetkin G, Otlu B, Cicek A, Kuzucu C, Durmaz R. Clinical,
microbiologic, and epidemiologic characteristics of Pseudomonas
aeruginosa infections in a University Hospital, Malatya, Turkey. Am J
Infect Control 2006;34(4);188-92.
Michelow IC, Olsen K, Lozano J, Rollins NK, Duffy LB, Ziegler T,
et al. Epidemiology and clinical characteristics of community-acquired
pneumonia in hospitalized children. Pediatrics 2004;113:701-7.
Smith RS, Iglewski BH. Pseudomonas aeruginosa quorum sensing as a
potential antimicrobial target. J Clin Invest 2003;112:1460-5.
Carolyn M. Slupsky, Streptococcus pneumoniae and Staphylococcus
aureus pneumonia induce distinct metabolic responses. J Proteome Res
;8(6):3029-36.
Scott JA, Wonodi C, Moïsi JC, Deloria-Knoll M, DeLuca AN,
Karron RA, et al. The definition of pneumonia, the assessment of
severity, and clinical standardization in the pneumonia etiology research
for child health study. Clin Infect Dis 2012;54 Suppl 2:S109-16.
Ulrich M, Herbert S, Berger J, Bellon G, Louis D, Münker G, et al.
Localization of Staphylococcus aureus in infected airways of patients
with cystic fibrosis and in a cell culture model of S. aureus adherence.
Am J Respir Cell Mol Biol 1998;19:83-91.
Teh BA, Choi SB, Musa N, Ling FL, Cun ST, Salleh AB, et al. Structure
to function prediction of hypothetical protein KPN_00953 (Ycbk) from
Klebsiella pneumoniae MGH 78578 highlights possible role in cell wall
metabolism. BMC Struct Biol 2014;14:7.
Kurup VP, Shen HD, Banerjee B. Respiratory fungal allergy. Microbes
Infect 2000;2(9):1101-10.
Austin A. Chemical characterization of gold and mercury based Siddha
sasthric preparation. Am J Drug Discov Dev 2012;2(3):110-23.
Hardy AD, Sutherland HH, Vaishnav R, Worthing MA. Report on the
composition of mercurials used in traditional medicines in Oman. J
Ethnopjharmacol 1995;49:17-22.
Savrikar SS, Ravishankar B. Introduction to ‘Rasashaastra’ the
iatrochemistry of ayurveda. Afr J Tradit Complement Altern Med
;8 5 Suppl:66-82.
Singh SK, Chaudhary A, Rai DK, Rai SB. Preparation and
characterization of a mercury based Indian traditional drug- RasSindoor
Indian J Tradit
Knowl 2009;8(3):346-51.
Venugopal V. Marine Products for Health Care, Functional Foods and
Neutraceuticals Series. Boca Raton, FL, USA: Taylor and Group, CRC
press; 2009.
Macha IJ, Cazalbou S, Ben-Nissan B, Harvey KL, Macha BJ. Marine
structure derived calcium phosphate–polymer biocomposites for local
antibiotic delivery. Mar Drugs 2015;13(1):666-80.
Sudesh, Gaidhani, Anantharaman M, Thenammal T, Krishnakumari
E, Veluchamy G. Pharmacological activities of Sivanar amirtham- A
Siddha preparation. J Res Ayurveda Siddha 29 Suppl 3:115-22.
Bérdy J. Thoughts and facts about antibiotics: Where we are now and
where we are heading. J Antibiot (Tokyo) 2012;65:385-95.
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