SYNTHESIS AND ANTIBACTERIAL SCREENING OF FEW NEW 5-MEMBERED HETEROCYCLIC SUGAR HYDRAZONES
Abstract
Objective: The aim of this study is to synthesize, characterize, and screen some new 5-membered heterocyclic sugar hydrazones for their antibacterial
activities.
Methods: A library of sugar hydrazones containing 2-benzofuryl, 2-thiophenyl, and 2-pyrrolyl motifs were synthesized. Structures of the newly
synthesized compounds were deduced based on spectral data and elemental analyses.
Results: Antibacterial activity was screened against Gram-positive and Gram-negative bacterial strains. Results were compared to gentamicin.
Compound 6a exhibited most potent antibacterial activity against all the tested strains.
Conclusion: 2-benzofuryl derivatives were observed to be good antibacterials.
Keywords: Benzofuran, Thiophene, Pyrrole, Antibacterial, Sugar.
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