SYNTHESIS AND EVALUATION OF NOVEL ISATIN DERIVATIVES FOR ANTIMICROBIAL ACTIVITY

Abstract

Final compound 3-({substituted phenyl [phenyldiazenyl] methylidene} hydrazinylidene)-1,3-dihydro-2H-indol-2-ones (VIa – VIe) which were prepaped by treatment of 3-(benzylidenehydrazinylidene)-1,3-dihydro-2H-indol-2-one(V) with hydrochloric acid, sodium nitrite and aryl amines (like anilines) in good yields. The structures of all compounds were confirmed by IR, ¹HNMR and mass spectral analysis. All the compounds were screened for their antibacterial and antifungal activities by using cup – plate method. Out of these compounds VIa and VId exhibited maximum activity. All the text compounds showed mild to moderate antibacterial and antifungal activities.

Key words: Isatin Derivatives, ¹HNMR, IR, Antibacterial Activity and Antifungal Activity.