ORAL CONTROL RELEASE MICROPARTICULATE DRUG DELIVERY STUDY OF ACECLOFENAC USING NATURAL POLYMER

Authors

  • Sunil Kumar Shah SRI SATYA SAI UNIVERSITY OF TECHNOLOGY & MEDICAL SCIENCES http://orcid.org/0000-0002-5232-6438
  • Chandra Kishore Tyagi
  • Deenanath Jhade
  • Priyanka Pandey

Abstract

Objective: The present study was to prepare controlled release microsphere of aceclofenac using sodium alginate as a natural polymer.
Methods: Microspheres of the Aceclofenac sodium by ionotropic gelation technique using sodium alginate as hydrophilic carrier and three different
cross-linking agent in various proportions and different condition drying, and examines the influences of various process such as drugs polymer ratio,
different concentration of cross linkage agents, drying condition, and cross-linking time on physicochemical properties of drug loaded microbeads.
Results: Formulated drug loaded microbeads were investigated for physicochemical properties and drug release potential. All investigated properties
showed satisfactory results. While increasing in the concentration of sodium alginate, and barium chloride cross-linking time increased sphericity, size
distribution, flow properties, mean particle size, swelling ratio, and drug entrapment efficiency. No significant effect of drug polymer interactions was
observed in Fourier transform infrared studies. The drug entrapment efficiency obtained in the range of 97.59-99.88. The particle size of drug loaded
formulations was measured by an optical microscope. The mean particle size of drug-loaded microbeads was found to be in the range 948.555±1.673
to 998.41±0.428. The shape and surface characteristics were determined by scanning electron microscopy using gold sputter technique. In-vitro drug
release profile of aceclofenac sodium from microbeads was examined in simulated gastric fluid pH 1.2 for initial 2 hrs mixed phosphate buffer pH 6.8
up to 6 hrs and simulated intestinal pH 7.4 at the end of 24 hrs studies. The release of drug from the microbeads was pH dependent, showed negligible
drug release in pH 1.2. Under pH 7.4 conditions the beads will swell, and the drug release depends on the swelling and erosion process resulting the
optimum level of drug released in a sustained manner and exhibited zero-order kinetics.
Conclusion: Result of studies this system was able to prolong the drug release, minimizing the drug-related adverse effects and improve bioavailability
in different GI-tract conditions.
Keywords: Controlled drug delivery, Aceclofenac sodium, Sodium alginate, Ionotropic gelation.

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Author Biography

Sunil Kumar Shah, SRI SATYA SAI UNIVERSITY OF TECHNOLOGY & MEDICAL SCIENCES

ASSISTANT PROFESSOR

PHARMACY

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Published

01-05-2016

How to Cite

Shah, S. K., C. Kishore Tyagi, D. Jhade, and P. Pandey. “ORAL CONTROL RELEASE MICROPARTICULATE DRUG DELIVERY STUDY OF ACECLOFENAC USING NATURAL POLYMER”. Asian Journal of Pharmaceutical and Clinical Research, vol. 9, no. 3, May 2016, pp. 229-35, https://journals.innovareacademics.in/index.php/ajpcr/article/view/11130.

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