FORMULATION OF IBUPROFEN LOADED ETHYL CELLULOSE NANOPARTICLES BY NANOPRECIPITATION TECHNIQUE
Abstract
ABSTRACT
Objective : The present study was undertaken to prepare and characterize drug loaded Ethyl cellulose nanoparticles using nanoprecipitation technique. The model drug chosen was Ibuprofen.
Method : These nanoparticles were prepared using nanoprecpitation technique in which the organic phase containing varied proportions of drug and the polymer was added drop wise to the aqueous phase having the stabilizer with continuous stirring. This resulted in the formation of precipitate in the aqueous phase. The stirring was continued for about 2 hours further. Then, the precipitate was collected by subjecting the sample to vacuum filtration and was air-dried.
Results : Â The best formulation among all the three was determined by comparing the particle size, stability and invitro drug release of all the formulation. F3 was considered as the best formulation with average particle size as 251.1 nm, zeta potential as -25.2 mV, and 86.02 % drug release which was sustained till 8 hours.
Conclusion: Â F3 formulation i.e; in which concentration of drug and polymer bears a ratio of 1:2 was concluded as the best because of their smaller particle size and greater stability.
Keywords : Acetone, Ethyl Cellulose(EC), Ethanol, Ibuprofen, Nanoparticles, Nanoprecipitation.
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