A STUDY ON ACUTE TOXICITY OF METHANOLIC EXTRACT OF MESUA FERREA L. IN SWISS ALBINO MICE

Abstract

Objective:To evaluate the Acute toxicological studies of the methanolic extract of dried flowers of Mesua ferrea in experimental female Swiss albino mice.

Methods: Acute toxicological studies of the methanolic extract of dried flowers of M.ferrea inexperimental female Swiss albino mice of four groups were conducted as per OECD guidelines. The parameters were screened such as Physical observation time, Body weight, food and water consumption, Haematological and biochemical parameters.The doses used were 50 mg/kg, 500 mg/kg and 2000 mg/kg.

Results: None of the group examined showed significant change in the body weights and mortality.At the dose levels tested, no toxicity signs were observed in the mice.There is no significant difference between control and treated animals in their haematological as well as biochemical test results.One way analysis of variance (ANOVA) was used to determine the significance between groups.

Conclusion: This study was concluded that the acute toxicity study of M.ferrea leafextract administered orally to mice did not caused any death or acute adverseeffect on the clinical observation and mortality to thetreatment animals.

Keywords: M. ferrea, methanolic extract, experimental female Swiss albino mice, acute toxicity.