EVALUATION OF WOUND HEALING ACTIVITY WITH A NEW FORMULATION OF DRY MANGIFERA INDICA AND HONEY USING SWISS ALBINO MICE
Abstract
ABSTRACT
Objective: A new formulation was made with dry M. indica power in combination with honey to understand the activity of wound healing on Swiss
albino mice.
Methods: Initially, animals were grouped into four groups, and a wound of 150 mm
was created. All the groups were taken for the study, and wound
contraction was studied on different days. The control group was treated with saline, Vitamin E was used as standard of the care, and other groups
were treated with 200 mg/kg and 500 mg/kg of the new formulation.
Results: Wound healing started after 4
th
2
day in the standard treated group, and the other formulation treated groups also started wound contraction
from 2
nd
day onward, whereas control did not show any wound contraction after 2
day. However, significant wound contraction observed after
treatment with 500 mg of formulation on the 10
th
nd
day, and this cannot be compared with the standard group on the 12
day. Even good wound
contraction observed with 200 mg/kg of the formulation which is similar to that of standard treated groups. The control group showed wound
contraction of about 34.72 mm
2
, whereas the standard group showed 9.58 mm
and the formulation-treated groups 200 mg/kg and 500 mg/kg
showed 15.39 mm
2
and 8.48 mm
2
.
2
Conclusion: This observation showed that a good wound contraction observed with a new formulation.
Keywords: Mangifera indica, Honey, Wound healing, Wound contraction, Swiss albino mice.
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