ASSESSMENT OF METABOLIC SYNDROME: ROLE OF SERUM FERRITIN
Abstract
ABSTRACT
Objective: The aim of the study is to explore the association between serum ferritin level and metabolic syndrome and its components.
Methods: Serum ferritin level and metabolic syndrome and its components were measured among 100 study subjects with respect to 25 healthy
controls at Santosh Medical College and Hospital, Ghaziabad. Fasting and post-prandial blood sugar level was estimated by using glucose oxidaseperoxidase
(POD)
method.
Total
cholesterol,
triglycerides,
and
high-density
lipoprotein
cholesterol
were
estimated
by
using cholesterol
oxidase
(CHOD)-POD
method,
glycerol-3-phosphate
oxidase-phenol
aminophenazone method, and Phosphotungustate/CHOD-POD
method,
respectively.
Low-density
lipoprotein
cholesterol
was
estimated
by
using Friedewald's
equation. Serum concentration
of ferritin
was
estimated
by
using Micro
ELISA
test
kit.
Cases and controls
were
compared
using Chi-square
test
and unpaired
Student's t-test
and p values
were
calculated.
Results: Significant relationship was observed between serum ferritin level and components of metabolic syndrome. Body mass index, blood sugar
level, and lipid profile were significantly (<0.05) different between the groups. Serum concentration of creatinine and urea was not significantly
(>0.05) different between the groups. Serum ferritin level was elevated in case group with metabolic syndrome and this difference was extremely
significant (<0.01) between the groups.
Conclusion: Serum ferritin, key regulator of iron homeostasis, can be used as indicator of progressing risk of metabolic syndrome.
Keywords: Dyslipidemia, Ferritin, Insulin resistance.
Downloads
References
REFERENCES
Boyd D, Vecoli C, Belcher DM, Jain SK, Drysdale JW. Structural and
functional relationships of human ferritin H and L chains deduced from
cDNA clones. J Biol Chem 1985;260(21):11755-61.
Bozzini C, Girelli D, Olivieri O, Martinelli N, Bassi A, De Matteis G,
et al. Prevalence of body iron excess in the metabolic syndrome.
Asian J Pharm Clin Res, Vol 9, Issue 4, 2016, 240-243
Sharma et al.
Diabetes Care 2005;28(8):2061-3.
Jehn M, Clark JM, Guallar E. Serum ferritin and risk of the metabolic
syndrome in US. adults. Diabetes Care 2004;27(10):2422-8.
Piperno A, Trombini P, Gelosa M, Mauri V, Pecci V, Vergani A, et al.
Increased serum ferritin is common in men with essential hypertension.
J Hypertens 2002;20(8):1513-8.
(a) Sharma P, Itagappa M, Kumar P, Sharma S. Gama glutamate
transferase and cardiovascular disease risk in young adults. Int J
Contemp Med 2013;1(2):32-5.
(b) Sharma R, Sharma P, Pradeep K, Tripathi GK. A correlation between
glycosylated hemoglobin and lipid profile in type – 2 diabetes mellitus
with and without complications. Int J Contemp Med 2015;3(2):120-5.
Allain CC, Poon LS, Chan CS, Richmond W, Fu PC. Enzymatic
determination of total serum cholesterol. Clin Chem 1974;20(4):470-5.
Friedewald WT, Levy RI, Fredrickson DS. Estimation of the
concentration of low-density lipoprotein cholesterol in plasma, without
use of the preparative ultracentrifuge. Clin Chem 1972;18(6):499-502.
McGowan MW, Artiss JD, Strandbergh DR, Zak B. A peroxidasecoupled
method for the colorimetric
determination of
serum
triglycerides.
Clin Chem 1983;29(3):538-42.
Trinder P. Determination of blood glucose using an oxidaseperoxidase
system
with a non-carcinogenic
chromogen. J
Clin
Pathol
;22(2):158-61.
Ferritin Human ELISA Kit. Available from: http://www.abcam.com/
ferritin-ftl-human-elisa-kit-ab108837.html. [Last accessed on 2016
Mar 18].
Wilson JG, Lindquist JH, Grambow SC, Crook ED, Maher JF.
Potential role of increased iron stores in diabetes. Am J Med Sci
;325(6):332-9.
Li J, Wang R, Luo D, Li S, Xiao C. Association between serum
ferritin levels and risk of the metabolic syndrome in Chinese adults: A
population study. PLoS One 2013;8(9):e74168.
Park SK, Ryoo JH, Kim MG, Shin JY. Association of serum ferritin
and development od metabolic syndrome in middle aged Korean men:
A 5 year follow up study. Diabetes Care 2012;35(12):2521-6.
Ryoo JH, Kim MG, Lee DW, Shin JY. The relationship between serum
ferritin and metabolic syndrome in healthy Korean men. Diabetes
Metab Res Rev 2011;27(6):597-603.
Hotamisligil GS. Molecular mechanisms of insulin resistance
and the role of the adipocyte. Int J Obes Relat Metab Disord
;24 Suppl 4:S23-7.
Halle M, König D, Berg A, Keul J, Baumstark MW. Relationship of
serum ferritin concentrations with metabolic cardiovascular risk factors
in men without evidence for coronary artery disease. Atherosclerosis
;128(2):235-40.
Li B, Lin W, Lin N, Dong X, Liu L. Study of the correlation between
serum ferritin levels and the aggregation of metabolic disorders in nondiabetic
elderly patients. Exp Ther
Med 2014;7(6):1671-6.
Williams MJ, Poulton R, Williams S. Relationship of serum ferritin
with cardiovascular risk factors and inflammation in young men and
women. Atherosclerosis 2002;165(1):179-84.
Ford ES, Cogswell ME. Diabetes and serum ferritin concentration
among US. adults. Diabetes Care 1999;22(12):1978-83.
Kim CH, Kim HK, Bae SJ, Park JY, Lee KU. Association of elevated
serum ferritin concentration with insulin resistance and impaired
glucose metabolism in Korean men and women. Metabolism
;60(3):414-20.
Mainous AG 3
, Weinberg ED, Diaz VA, Johnson SP, Hulihan MM,
Grant AM. Calcium channel blocker use and serum ferritin in adults
with hypertension. Biometals 2012;25(3):563-8.
rd
Aderbique OR, Pisa PT, Mamabolo RL, Kurger HS, Vorster HH. The
relationship between indices of iron stores and selected anthropometric
cardiovascular disease risk makers in an African population: THUSA
study. Cardiovasc J Afr 2011;22(5):249-56.
Published
How to Cite
Issue
Section
The publication is licensed under CC By and is open access. Copyright is with author and allowed to retain publishing rights without restrictions.