STUDY OF THE POSSIBLE ANTIHYPERTENSIVE AND HYPOLIPIDEMIC EFFECTS OF AN HERBAL MIXTURE ON L-NAME-INDUCED HYPERTENSIVE RATS
DOI:
https://doi.org/10.22159/ajpcr.2016.v9i5.12175Abstract
Objective: Hypertension is a chronic medical condition. Diet can improve blood pressure control and decrease the risk of health complication.
Methods: In this study, four plants: Roselle, Marjoram, Chamomile, and Doum were extracted by water. Equal portions of them were mixed. Lethal
dose 50% of the mixture was assayed; the dose which did not cause any mortality was 266.94 mg/100 g body weight. Animals were classified into five
groups: Negative control group, positive control group where hypertension was induced by L-name, two groups treated with two doses of the mixture,
and a group treated with prazosin as a standard treatment. Treatment of hypertensive rats continued for 4 successive weeks.
Results: Treatment with the mixture showed a significant reduction in blood pressure of hypertensive rats, as well as serum cholesterol, low-density
lipoprotein-cholesterol, and urea levels when compared to positive control group.
Conclusion: The results obtained suggest that the aqueous extract is efficient as an antihypertensive and hypolipidemic agent.
Keywords: Rats, Aqueous extract, Hypertension, Hyperlipidemia, L-name.
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