FORMULATION AND EVALUATION OF HERBAL ANTIACNE GEL OF MYRICA ESCULENTA
Abstract
ABSTRACT
Objective: The present study was conducted to formulate and evaluate the topical anti-acne formulation of Myrica esculenta extract and its isolated
essential oil.
Methods: The antibacterial activity of crude extract and essential oil of M. esculenta against Propionibacterium acne, Staphylococcus epidermidis, and
Staphyloccocus aureus was investigated using disc diffusion method. After finding active, the topical gel formulations were developed and tested for
physical parameters, drug content uniformity, and in-vitro diffusion.
Results and Discussions: The results revealed that M. esculenta crude extract and essential oil showed the minimum inhibitory concentration values
of 2.1 mg/ml and 1.7 mg/ml respectively against P. acne. It was revealed from the results that formulation F5 showed the maximum drug content
(94.6%), in-vitro diffusion (93%), maximum stability and the zone of inhibition among all the formulations.
Conclusions: From the present study, it can be concluded that the M. esculenta extract and essential oil have potential against Acne vulgaris. Among
the formulations developed, F5 was considered as the optimized formulation with desired profile.
Keywords: Myrica esculenta, Acne vulgaris, Hydrogel, In-vitro evaluation, Propionibacterium acne.
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References
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