TO EVALUATE THE HYPOGLYCEMIC EFFECT OF THE FRUIT PULP EXTRACT OF SPONDIAS PINNATA LINN. KURZ ON EXPERIMENTAL MODEL OF DIABETES MELLITUS

Abstract

ABSTRACT
Objective: To study the hypoglycemic effect of the fruit pulp extract of Spondias pinnata Linn. Kurz (EESP) on an experimental model of diabetes in
albino rats.
Methods: A total of 30 healthy adult Swiss albino rats of either sex weighing between 150 g and 200 g were divided into five groups containing
6 animals each. All the animals were kept under fasting for 24 hrs. Animals were given free access to rat - chew and water ad libitum. Alloxan
monohydrate of 120 mg/kg in normal saline was given intraperitoneally to induce diabetes. The blood glucose was checked before alloxanization and
after 24 hrs of alloxanization by withdrawing blood from the tip of the tail of each rat under anesthesia. The animals were considered diabetic when
the blood glucose level has raised beyond 225 mg/dl. Group A, which was control group, has received alloxan and normal saline. The standard drug,
glibenclamide 2.5 mg/kg, was given orally in Group B. Group C, Group D, and Group E animals have received EESP orally at the dose of 100 mg/kg,
200 mg/kg, and 400 mg/kg, respectively. Blood samples were collected after treatment from rat tails vein at 0 hr, 2 hrs, 4 hrs, 8 hrs, and 14 days. Data
obtained were analyzed by one-way analysis of variance followed by Tukey's multiple comparison test.
Results: EESP has shown hypoglycemic action in alloxan-induced diabetic rats. Hypoglycemic action of this ethanolic extract is comparable to that of
glibenclamide.
Conclusion: This study demonstrates hypoglycemic action of EESP in the experimental model of diabetic rats.
Keywords: Hypoglycemic, Spondias pinnata, Diabetes mellitus.