• Bhupesh CS
  • Rohit B
  • Kalyani D



Objective: The aim of this study is to explore the antinociceptive property of hydroalcoholic extract of Malvastrum coromandelianum. Pain is an
unpleasant sensory and emotional experience associated with actual and potential tissue damage. Various types of pain are seen in humans, somatic,
visceral, and neuropathic pain. M. coromandelianum belongs to Malvaceae family. Traditionally, it is used as an emollient, anti-inflammatory, analgesic,
and antidysenteric.

Methods: The antinociceptive effects of hydroalcoholic extract of M. coromandelianum (HEMC) were evaluated by tail-flick, hot-plate, and acetic acid induced writhing method. Rats were divided into four groups. The first group which served as control was administered with aqueous 1% tragacanth
suspension. The second group received standard drug, morphine (5 mg/kg) orally as a suspension. Third and fourth group received HEMC (200 and
400 mg/kg) and served as test drug treatment group, 30 minutes after treatment the reaction time and number of writhes was noted.

Results: HEMC produced significant antinociceptive effects against thermally induced pain. In tail-flick method, the peak effect of HEMC 400 mg/kg
was shown at 60 minutes which is nearly equal to the peak effect of morphine 5 mg/kg. In hot-plate method, the HEMC showed significant analgesic
effect up to 3 hrs after the treatment, whereas morphine showed significant effect up to 6 hrs.

Conclusion: On the basis of finding, it may conclude that the HEMC shows its central analgesic action probably through inhibition of central pain receptors, whereas peripheral analgesic effect may be mediated by prostaglandin inhibition.

Keywords: Pain, Analgesia, Hydroalcoholic extract of Malvastrum coromandelianum, Morphine.


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Seattle WA. Classification of Chronic Pain: Descriptions of Chronic Pain Syndromes and Definitions of Pain Terms. Seattle: IASP Press; 1994.

Fields HL, Levine JD. Pain - mechanics and management. West J Med 1984;141(3):347-57.

Benett PN, Brown MJ. Clinical Pharmacology. 9th ed., Vol. 3. London: Churchill Livingstone; 2003. p. 19-22.

Rang HP, Dale MM, Ritter JM, Moore PR. Pharmacology. 6th ed. Edinburg: Elsevier; 2007. p. 589.

Serpell M. Anatomy, physiology and pharmacology of pain. Surgery (Oxford) 2006;24(10):350-3.

Strigo IA, Duncan GH, Boivin M, Bushnell MC. Differentiation of visceral and cutaneous pain in the human brain. J Neurophysiol 2003;89(6):3294-303.

Meyerson BA, Linderoth B. Mode of action of spinal cord stimulation in neuropathic pain. J Pain Symptom Manage 2006;31 4 Suppl: S6-12.

Almeida SM, Almeida MR. Dictionary of Generic Names of Flowering Plants and Ferns in Maharashtra. Mumbai: Orient Press Ltd.; 2005. p. 202.

Chopra RN, Nayar SL, Chopra IC. Glossary of Indian Medicinal Plants. 7th ed. New Delhi: National Institute of Science Communication and Information Resources; 2006. p. 161.

The wealth of India. A Dictionary of Indian Raw Materials and Industrial Products. 1st ed. New Delhi: National Institute of Science Communication and Information Resources; 2003. p. 89.

Dahanukar SA, Kulkarni RA, Rege NN. Pharmacology of medicinal plants and natural products. Ind J Pharmacol 2000;32(4):81-118.

Khare CP. Indian Medicinal Plants: An Illustrated Dictionary. 1st ed. New Delhi: Springer Private Limited; 2007. p. 396.

Kokate CK. Practical Pharmacognosy. 3rd ed. New Delhi: Vallabh Prakashan; 1991. p. 107-11.

Khandelwal KR. Practical Pharmacognosy. 10th ed. New Delhi: Nirali Prakashan; 2003. p. 149.

Marinho BG, Miranda LS, Gomes NM, Matheus ME, Leitão SG, Vasconcellos ML, et al. Antinociceptive action of (/-)-cis-(6-ethyl-tetrahydropyran-2-yl)-formic acid in mice. Eur J Pharmacol 2006;550(1-3):47-53.

Ojewole JA. Antinociceptive, anti-inflammatory and antidiabetic properties of Hypoxis hemerocallidea Fisch. & C.A. Mey. (Hypoxidaceae) corm [‘African Potato’] aqueous extract in mice and rats. J Ethnopharmacol 2006;103(1):126-34.

Reddy YS, Sama V, Suresh B. Antinociceptive activity of Malvastrum Coromandelianum. Fitoterapia 2001;72(3):278-80.

Ramabadran K, Bansinath M, Turndorf H, Puig MM. Tail immersion test for the evaluation of a nociceptive reaction in mice. Methodological considerations. J Pharmacol Methods 1989;21(1):21-31.

Krasteva I, Platikanov S, Nikolov S, Kaloga M. Flavonoids from Astragalus hamosus. Nat Prod Res 2007;21(5):392-5.

Ramabadran K, Bansinath M, Turndorf H, Puig MM. Tail immersion test for the evaluation of a nociceptive reaction in mice. Methodological considerations J Pharm Methods 1989;21:21-31.

Srinivasan K, Muruganandan S, Lal J, Chandra S, Tandan SK, Raviprakash V, et al. Antinociceptive and antipyretic activities of Pongamia pinnata leaves. Phytother Res 2003;17(3):259-64.

Bodnar RJ, Hadjimarkou MM. Endogenous opiates and behavior: 2001. Peptides 2002;23(12):2307-65.

Schaible HG, Richter F. Pathophysiology of pain. Langenbecks Arch Surg 2004;389(4):237-43.

Deraedt R, Jouquey S, Delevallée F, Flahaut M. Release of prostaglandins E and F in an algogenic reaction and its inhibition. Eur J Pharmacol 1980;61(1):17-24.

Duarte ID, Nakamura M, Ferreira SH. Participation of the sympathetic system in acetic acid-induced writhing in mice. Braz J Med Biol Res 1988;21(2):341-3.



How to Cite

Bhupesh CS, R. B, and K. D. “ANALGESIC ACTIVITY OF HYDROALCOHOLIC EXTRACT OF AERIAL PARTS OF MALVASTRUM COROMANDELIANUM”. Asian Journal of Pharmaceutical and Clinical Research, vol. 9, no. 5, Sept. 2016, pp. 146-9, doi:10.22159/ajpcr.2016.v9i5.12822.



Original Article(s)