A PROSPECTIVE STUDY ON IMPACT OF PATIENT COUNSELLING ON QUALITY OF LIFE AND MEDICATION ADHERENCE IN EPILEPTIC PATIENTS

Ayswarya P; Sathesh Kumar s

doi:10.22159/ajpcr.2017.v10i1.13106

Authors

Ayswarya P
Sathesh Kumar s Professor and HOD,Department of Pharmacuetics,School of Pharmaceutical Sciences,Vels Institute of Science Technology and Advanced Studies (VISTAS),Vels University,Pallavaram, Chennai-600117.

DOI:

https://doi.org/10.22159/ajpcr.2017.v10i1.13106

Abstract

Objective: To study the impact of patient counseling on medication adherence and quality of life (QOL) in epileptic patients and to assess the factors affecting medication adherence.

Methods: This study is a prospective observational study involving 100 patients with an age limit of 8-60 years and those taking Antiepileptic drugs for at least 3 months. The study population received patient counseling during their first visit. The impact of patient counseling on QOL and medication adherence was assessed using self-reported questionnaire QOLIE-31 and MMAS-8 between the first visit and the second visit. Statistical analysis (Paired t-test and Paired Chi-square test) was performed to analyze the impact of patient counseling on QOL and medication adherence in epileptic patients.

Results: A total of 100 patients were included in the study. After providing patient counseling, it was observed that there was a statistically significant (p<0.05) improvement in all domains of QOLIE-31 and MMAS-8 scores. Before counseling, mean overall T-score of QOLIE-31 was 44.08Â±2.07which was changed to 49.14Â±1.27 after patient counseling with a mean change of 5.06 in overall T-score. In the case of medication adherence, before counseling 77% subjects were nonadherent to therapy, after counseling it was reduced to 41%. The common reasons for medication adherence were forgetfulness, unawareness, therapy related, and economics related. Out of which forgetfulness along with unawareness was the major one.

Conclusion: The study described that patient counseling plays a major role in improving QOL and medication adherence.

Keywords: QOLIE-31, MMAS-8, Epilepsy, Antiepileptic drugs, Patient counseling.

Â

Downloads

Download data is not yet available.

Author Biography

Sathesh Kumar s, Professor and HOD,Department of Pharmacuetics,School of Pharmaceutical Sciences,Vels Institute of Science Technology and Advanced Studies (VISTAS),Vels University,Pallavaram, Chennai-600117.

Professor and HOD,
Department of Pharmacuetics,
School of Pharmaceutical Sciences,
Vels Institute of Science Technology and Advanced Studies (VISTAS),
Vels University,
Pallavaram, Chennai-600117.

References

Haut SR, VelÃskovÃ¡ J, MoshÃ© SL. Susceptibility of immature and adult brains to seizure effects. Lancet Neurol 2004;3(10):608-17.

About Epilepsy. US Department of Veterans Affairs; 2015. Available from: http://www.VA/healthcare/epilepsy centers of excellence/about epilepsy. [Last cited on 2015 Jun 3].

Schachter CS. Epilepsy Foundation. Available from: http://www. epilepsy. com/learn/types-seizures.

Gabr WM, Shams ME. Adherence to medication among outpatient adolescents with epilepsy. Saudi Pharm J 2015;23(1):33-40.

Martins HH, Alonso BN, Guilho FF, Guaranha BS, Yacubian TM. Adherence to treatment in patients with juvenile myoclonic epilepsy: Correlation with QOL and ADR of medication. J Epilepsy Clin Neurophysiol 2009;15(4):192-6.

Johnbull OS, Farounbi B, Adeleye AO, Ogunrin O, Uche AP. Evaluation of factors influencing medication adherence in Kaduna state Nigeria. Neurosci Med 2011;2(4):299-305.

Study: What Affects Quality of Life in Patients with Epilepsy? Available from: https://www.freshsciencenews.wordpress.com/2015/06/12/ study-what-affects-quality-of-life-in-patients-with-epilepsy/. [Last updated on 2014 Jun ???].

Berto P. Quality of life in patients with epilepsy and impact of treatments. Pharmacoeconomics 2002;20(15):1039-59.

Ahmad N, Othaman NI, Islahudin F. Medication adherence and quality of life in epilepsy patients. Int J Pharm Pharm Sci2013;5(2):401-4.

McCagh J, Fisk JE, Baker GA. Epilepsy, psychosocial and cognitive functioning. Epilepsy Res 2009;86(1):1-14.

Kerr MP, The impact of epilepsy on patientsâ€™lives. Acta Neurol Scand Suppl.2012;(194):1-9. DOI: 10.1111/ane.12014.

Hovinga CA, Asato MR, Manjunath R, Wheless JW, Phelps SJ, Sheth RD, et al. Association of non-adherence to antiepileptic drugs and seizures, quality of life, and productivity: Survey of patients with epilepsy and physicians. Epilepsy Behav 2008;13(2):316-22.

Ashjazadeh N, Yadollahikhales G, Ayoobzadehshirazi A, Sadraii N, Hadi N. Comparison of the health-related quality of life between epileptic patients with partial and generalized seizure. Iran J Neurol 2014;13(2):94-100.

Garnett WR. Antiepileptic drug treatment: Outcomes and adherence. Pharmacotherapy 2000;20(8):191S-9.

Nabukenya AM, Matovu JK, Wabwire-Mangen F, Wanyenze RK, Makumbi F. Health-related quality of life in epilepsy patients receiving anti-epileptic drugs at National Referral Hospitals in Uganda: A cross- sectional study. Health Qual Life Outcomes 2014;12:49.

Gabr WM and Shams MEE, Adherence to medication among outpatient adolescents with epilepsy, Saudi

Pharmaceutical Journal, 2015;23 (1): 33-40.

Brusturean BE, Coada CA, Buzoianu AD, Dumbrava LP. Assessment of quality of life in patients with epilepsy. Int J Bioflux Soc 2013;5(3):82-7.

Sweileh WM, Ihbesheh MS, Jarar IS, Taha AS, Sawalha AF, Zyoud SH, et al. Self-reported medication adherence and treatment satisfaction in patients with epilepsy. Epilepsy Behav 2011;21(3):301-5.

Dourado MV, Alonso NB, Martins HH, Oliveira AR, Vancini RL, de Lima C, et al. Quality of life and self - Perception impact of epilepsy in three different epilepsy types. J Epilepsy Clin Neurophysiol 2007;13(4):191-6.

Shanmukhi S, SitaJayalakshmi S, Anand. B. Factors associated with quality of life in adult epilepsy patients: A hospital based study from South India, Res Neurol Int J 2015;2015:Article ID: 766328, DOI: 10.5171/2015.766328.