PERIOPERATIVE EFFECTS OF INTRATHECAL CLONIDINE AND FENTANYL WITH HYPERBARIC BUPIVACAINE IN SPINAL ANESTHESIA FOR VAGINAL HYSTERECTOMY

Mallika Datta; Suman Chattopadhyay; Biswanath Biswas

doi:10.22159/ajpcr.2016.v9i5.13382

Authors

Mallika Datta Medical College & Hospital, Kolkata
Suman Chattopadhyay Midnapore Medical College and Hospital, West Bengal
Biswanath Biswas Professor and Head of Anesthesiology, IQ City Medical College & Hospital, West Bengal and formerly Professor of Anesthesiology, Medical College & Hospital, Kolkata

DOI:

https://doi.org/10.22159/ajpcr.2016.v9i5.13382

Abstract

Objectives: Intrathecal fentanyl and clonidine are effective analgesics with different mechanisms of action. This study compares 25 Î¼g of both these
drugs given intrathecally regarding onset, quality, and duration of hyperbaric bupivacaine-induced spinal block and side effects.

Methods: A total of 90 patients of ASA I and II were randomly allocated into three equal groups. Group A received 0.5 ml of 0.9% normal saline
(placebo), Group B and Group C received 25 Î¼g fentanyl and clonidine intrathecally added to 2.5 ml of 0.5% hyperbaric bupivacaine, respectively. The
onset and regression time of sensory and motor blocks were recorded along with hemodynamic change, side effects, pain intensity (in terms of visual
analog score (VAS), and time to first rescue analgesic.

Results: Intrathecal clonidine (25 Î¼g) significantly prolongs sensory and motor blocks, with prolonged duration of analgesia in comparison with
intrathecal fentanyl (25 Î¼g) (325Â±15 minutes vs. 240Â±7.6 minutes). VAS score was similar, but sedation was more in clonidine group.

Conclusion: We conclude that low-dose intrathecal clonidine is an effective adjuvant to bupivacaine for spinal anesthesia and provides better
postoperative analgesia in comparison with intrathecal fentanyl.

Keywords: Clonidine, Fentanyl, Bupivacaine, Regional, Spinal, Postoperative pain.

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Author Biographies

Mallika Datta, Medical College & Hospital, Kolkata

Assistant Professor of Gynaecology & Obstetrics,

Suman Chattopadhyay, Midnapore Medical College and Hospital, West Bengal

Associate Professor of Anesthesiology,

Midnapore Medical College & Hospital, West Bengal

and formerly Associate Professor of Anesthesiology, Medical College & Hospital, Kolkata

Biswanath Biswas, Professor and Head of Anesthesiology, IQ City Medical College & Hospital, West Bengal and formerly Professor of Anesthesiology, Medical College & Hospital, Kolkata

Professor and Head of Anesthesiology, IQ City Medical College & Hospital, West Bengal
and formerly Professor of Anesthesiology, Medical College & Hospital, Kolkata

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