• Ari Yuniarto Bandung Institute of Technology
  • Kusnandar Anggadiredja
  • Riana Annisa Nur Aqidah



Objective: In general, infectious diseases still known as a major contributor to the number of morbidity and mortality in the worldwide beside
other diseases. Infections are ordinarily caused by viruses, bacteria, and fungi. Several human pathogenic fungi involving Aspergillus flavus, Candida
albicans, and Microsporum gypseum have responsible against infectious diseases. The objective of the research was to evaluate the antifungal activity
of kombucha tea against human pathogenic fungi such as A. flavus, C. albicans, and M. gypseum.

Methods: The antifungal activity of the kombucha tea against A. flavus, C. albicans, and M. gypseum were tested by disc diffusion method with duration
of fermentation in 6, 12, and 18 days.

Results: Based on the present study, inhibitory diameter of A. flavus, C. albicans, and M. gypseum are 16.83, 15.36, and 25.06 mm, respectively. The
inhibitory diameter was obtained from kombucha tea activity with duration of fermentation in 6 days.

Conclusion: The results provide support for the use of kombucha tea as a potential antifungal source against human pathogenic fungi involving
A. flavus, C. albicans, and M. gypseum.

Antifungal, Kombucha tea, Pathogenic, Fungi.


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Author Biography

Ari Yuniarto, Bandung Institute of Technology

School of Pharmacy and Rank of 125 in Southeast Asia (2014)


Crum-Cianflone NF. Bacterial, fungal, parasitic, and viral myositis. Clin Microbiol Rev 2008;21(3):473-94.

Blanco JL, Garcia ME. Immune response to fungal infections. Vet Immunol Immunopathol 2008;125(1-2):47-70.

Samonis G, Bafaloukos D. Fungal infections in cancer patients: An escalating problem. In Vivo 1992;6(2):183-93.

Silveira FP, Husain S. Fungal infections in solid organ transplantation. Med Mycol 2007;45(4):305-20.

Vandeputte P, Ferrari S, Coste AT. Antifungal resistance and new strategies to control fungal infections. Int J Microbiol 2012;2012:713687.

Jayabalan R, Malbasa RV, Loncar ES, Vitas JS, Sathiskumar M. A review on kombucha-microbiology, composition, fermentation, and beneficial effects, toxicity, and tea fungus. Compr Rev Food Sci Food Saf 2014;13:538-50.

Essawet NA, Cvetkovic D, Velicanski A, Canadanovic-Brunet J, Vulic J, Maksimovic V, et al. Polyphenol and antioxidant activities of kombucha beverage enriched with coffeeberry ® extract. Chem Chem Eng Q 2015;21(3):399-409.

Goh WN, Rosma A, Kaur B, Fazilah A, Karim AA, Rajeev B. Fermentation of black tea broth (Kombucha): I. Effects of sucrose concentration and fermentation time on the yield of microbial cellulose. Int Food Res J 2012;19(1):109-17.

Velicanski A, Cvetkovic D, Markov S. Characteristics of kombucha fermentation on medicinal herbs from lamiaceae family. Rom Biotechnol Lett 2013;18(1):8034-42.

Frank GW. Kombucha: Healthy Beverage and Natural Remedy and Natural Remedy from the Far East. Austria: Wilhelm Ennsthaler; 1995.

Junior RJ, Batista RA, Rodrigues SA, Filho LX, Lima AS. Antimicrobial activity of broth fermented with kombucha colonies. J Microb Biochem Technol 2009;1(1):72-8.

Greenwalt CJ, Ledford RA, Streinkraus KH. Determination and characterization of the antimicrobial activity of the fermented tea kombucha. Leben Wissen Tech 1998;31:291-6.

Lu HJ, Breidt F Jr, Pérez-Díaz IM, Osborne JA. Antimicrobial effects of weak acids on the survival of Escherichia coli O157:H7 under anaerobic conditions. J Food Prot 2011;74:893-8.

Khatry S, Sirish KS, Shastri N, Sadanandam M. Novel drug delivery systems for antifungal therapy. Int J Pharm Pharm Sci 2010;2(4):6-9.



How to Cite

Yuniarto, A., K. Anggadiredja, and R. Annisa Nur Aqidah. “ANTIFUNGAL ACTIVITY OF KOMBUCHA TEA AGAINST HUMAN PATHOGENIC FUNGI”. Asian Journal of Pharmaceutical and Clinical Research, vol. 9, no. 5, Sept. 2016, pp. 253-5, doi:10.22159/ajpcr.2016.v9i5.13432.



Original Article(s)