ANTIOXIDANT PROPERTY OF ANTIHYPERTENSIVE DRUGS (CARVEDILOL, ENALAPRIL, AND AMLODIPINE) ON LIVER FUNCTION IN ANIMAL (RATS) MODELS
DOI:
https://doi.org/10.22159/ajpcr.2016.v9s2.13924Abstract
ABSTRACT
Objective: The antihypertensive drugs (beta-blockers - carvedilol, calcium channel blocker - amlodipine, and angiotensin-converting enzyme
inhibitor - enalapril) were investigated for its hepatoprotective effect by antioxidant property against carbon tetrachloride (CCl
)-induced acute liver
damage on albino rats.
Methods: In this study the liver was damaged by giving Carbon tetra chloride (CCl
4
)-1 ml/kg-p.o. After giving CCl
(1 ml/kg), it significantly elevated
the serum levels of biochemical markers such as serum glutamate-pyruvate transaminase, serum glutamic oxaloacetic transaminase, alkaline
phosphatase, total bilirubin, protein, and depleted antioxidant enzymes glutathione. After treatment with carvedilol (10 mg/kg), enalapril (0.5 mg/kg),
and amlodipine (10 mg/kg) for 2 weeks, these drugs were significantly reduces the elevated levels of biochemical markers mentioned above.
Conclusion: These results suggest that these antihypertensive drugs may have the potential therapeutic value in the treatment of CCl
4
-induced
hepatic damage and some liver diseases. Hepatoprotective activity of these drugs may be attributed to the antioxidant principles in it.
Keywords: Antioxidant, Carvedilol, Enalapril, Amlodipine, Carbon tetrachloride, Hepatoprotective.
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