A CASE REPORT ON ROLE OF N-ACETYLCYSTEINE IN NON–ACETAMINOPHEN RELATED ACUTE LIVER INJURY
DOI:
https://doi.org/10.22159/ajpcr.2016.v9i6.13978Abstract
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Acute liver failure is a clinical entity associated with a high mortality rate and majority of these patients may require liver transplantation. N-Acetylcysteine (NAC), an antioxidant agent that replenishes mitochondrial and cytosolic glutathione stores, is an antidote for acetaminophen poisoning. But their role in non–acetaminophen-related acute liver failure is still not proven. Here, we discuss about a 67 year old male patient diagnosed with hepatitis with acute liver injury who was admitted in Emergency Medicine. He was treated with N- Acetylcysteine infusion for an average of 48 hours and later it was found that his liver function tests improved. In this study, we could find that N-Acetylcysteine plays a major role in improving the liver function test of patients with non–acetaminophen-related acute liver failure.
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Michael L. Schilsky, Shyoko Honiden, Lindsay Arnott, Sukru Emre, ICU Management of Acute Liver Failure, Clin Chest Med, 2009 ; 30 : 71–87
A. W. Holt, Acute Liver Failure, Critical Care and Resuscitation, 1999; 1: 25-38
Christine Kortsalioudaki, Rachel M. Taylor, Paul Cheeseman, Sanjay Bansal, Giorgina Mieli-Vergani, Anil Dhawan, Safety and Efficacy of N-Acetylcysteine in Children With Non-Acetaminophen-Induced Acute Liver Failure, Liver Transplantation, 2008: 14; 25-30
Mohamed Farouk Chughlay, Nicole Kramer, Mahmoud Werfalli, Wendy Spearman, Mark Emmanuel Engel, Karen Cohenl. Chughlay et al N-acetylcysteine for non-paracetamol drug-induced liver injury: a systematic review protocol, Systematic Reviews, 2015: 4:84.
Robert H. Squires, Anil Dhawan, Estella Alonso, Michael R. Narkewicz, Benjamin L. Shneider,Norberto Rodriguez-Baez, Dominic Dell Olio. Intravenous N-acetylcysteine in Pediatric Patients With Non Acetaminophen Acute Liver Failure: A Placebo-Controlled Clinical Trial. Hepatology, 2013: 57; 4
WilliamMLee, LindaSHynanetal. Intravenous N-Acetylcysteine improves transplant free survival in early stage non acetaminophen acute liver failure. Gastroenterology,2009 ; 3 : 856-864
Stephanie Bass, Nathaniel Zook. Intravenous Acetylcysteine for indication other than acetaminophen overdose. American journal of health - System Pharmacy, 2013 : 70(17) ; 1496-1501.
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