EFFECT OF DAIDZEIN 120 MG SUPPLEMENTATION TO MENOPAUSAL SYMPTOMS AND QUALITY OF LIFE IN NON EQUOL PRODUCER WOMEN
DOI:
https://doi.org/10.22159/ajpcr.2016.v9s3.14023Abstract
ABSTRACT
Objectives: To investigate and compare symptom changes and quality of life (QOL) in non equol producer postmenopausal women after consuming
daidzein supplementation.
Methods: This was a single randomized clinical trial. It involved menopausal women. They were divided into two groups, one received placebo that
contains calcium glycerophosphate 500 mg, vitamin D3 35 IU and daidzein group contain daidzein 120 mg, contain calcium glycerophosphate 500 mg,
vitamin D3 140 IU for 8 weeks. Plasma equol was measured before supplementation. Menopause QOL (MenQOL) questionnaires have been utilized in
the beginning and the end of treatment to assess the QOL.
Results: A total of 41 women age 45-63 years old were included in this trial, 19 (47.5%) of them receive daidzein supplementation and others
received control treatment. Menopausal symptoms decreased but not statistically significant compare to control group.
Conclusion: About 8 weeks daidzein supplementation was not statistically improved MenQOL status in non equol producer postmenopausal women.
Keywords: Menopause, Quality of life, Menopausal symptom, Isoflavone, Daidzein, Menopause quality of life.
Downloads
References
Gold EB. The timing of the age at which natural menopause occurs. Obstet Gynecol Clin North Am 2011;38(3):425-40.
Fritz MA, Speroff L. Menopause and perimenopausal transision. In: Seigafuze S, editor. Clinical Gynecology, Endocrinology and Infertility. 8th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2011. p. 673-748.
Badan Pusat Statistik B, Kemenkes, ICF International. Survey Demografi Kesehatan Indonesia 2012. Jakarta, Indonesia: BPS, BKKBN, Kemenkes, ICF International; 2013.
Mohammadalizadeh Charandabi S, Rezaei N, Hakimi S, Montazeri A, Taheri S, Taghinejad H, et al. Quality of life of postmenopausal women and their spouses: A community-based study. Iran Red Crescent Med J 2015;17(3):e21599.
ACOG Practice Bulletin No 141: Management of menopausal symptoms. Obstet Gynecol 2014;123(1):202-16.
Grant MD, Marbella A, Wang AT, Pines E, Hoag J, Bonnell C, et al. Menopausal Symptoms: Comparative Effectiveness of Therapies. Rockville, MD: Agency for Healthcare Research and Quality (US); 2015.
Makara-Studzińśka MT, Kryś-Noszczyk KM, Jakiel G. Epidemiology of the symptoms of menopause–an intercontinental review. Prz Menopauzalny 2014;13(3):203-11.
Haines CJ, Xing SM, Park KH, Holinka CF, Ausmanas MK. Prevalence of menopausal symptoms in different ethnic groups of Asian women and responsiveness to therapy with three doses of conjugated estrogens/medroxyprogesterone acetate: The Pan-Asia Menopause (PAM) study. Maturitas 2005;52(3-4):264-76.
Ishiwata N, Melby MK, Mizuno S, Watanabe S. New equol supplement for relieving menopausal symptoms: Randomized, placebo-controlled trial of Japanese women. Menopause 2009;16(1):141-8.
Kok L, Kreijkamp-Kaspers S, Grobbee DE, Lampe JW, van der Schouw YT. A randomized, placebo-controlled trial on the effects of soy protein containing isoflavones on quality of life in postmenopausal women. Menopause 2005;12(1):56-62.
Persky VW, Turyk ME, Wang L, Freels S, Chatterton R Jr, Barnes S, et al. Effect of soy protein on endogenous hormones in postmenopausal women. Am J Clin Nutr 2002;75(1):145-53.
Hooper L, Ryder JJ, Kurzer MS, Lampe JW, Messina MJ, Phipps WR, et al. Effects of soy protein and isoflavones on circulating hormone concentrations in pre- and post-menopausal women: A systematic review and meta-analysis. Hum Reprod Update 2009;15(4):423-40.
Atkinson C, Newton KM, Bowles EJ, Yong M, Lampe JW.Demographic, anthropometric, and lifestyle factors and dietary intakes in relation to daidzein-metabolizing phenotypes among premenopausal women in the United States. Am J Clin Nutr 2008;87(3):679-87.
Rafii F. The role of colonic bacteria in the metabolism of the natural isoflavone daidzin to equol. Metabolites 2015;5(1):56-73.
Utian WH, Jones M, Setchell KD. S-equol: A potential nonhormonal agent for menopause-related symptom relief. J Womens Health (Larchmt) 2015;24(3):200-8.
Setchell KD, Clerici C, Lephart ED, Cole SJ, Heenan C, Castellani D, et al. S-equol, a potent ligand for estrogen receptor beta, is the exclusive enantiomeric form of the soy isoflavone metabolite produced by human intestinal bacterial flora. Am J Clin Nutr 2005;81(5):1072-9.
Huang KE, Xu L, Nasri N, Jaisamrarn U. The Asian Menopause Survey: Knowledge, perceptions, hormone treatment and sexual function. Maturitas 2010;65(3):276-83.
Farquhar C, Marjoribanks J, Lethaby A, Suckling J, Lamberts Q. Long term hormone therapy for perimenopausal and postmenopausal women. Cochrane Database Syst Rev 2009;2:CD004143.
American College of Obstetricians and Gynecologists. ACOG Practice Bulletin no. 28: Clinical Management Guidelines for Obstetrician-Gynecologists. Use of botanicals for management of menopausal symptoms. Obstet Gynecol 2001;97(6):suppl 1-11.
Menopause Guidelines Revision Task Force A. American Association of Clinical Endocrinologists medical guidelines for clinical practice for the diagnosis and treatment of menopause. Endocr Pract 2006;12(3):315-37.
Aso T. Quality of Life: Asian Women and the Menopause. Med Sci Symp Ser 2002;17:353-60.
Anderson D, Yoshizawa T, Gollschewski S, Atogami F, Courtney M. Menopause in Australia and Japan: Effects of country of residence on menopausal status and menopausal symptoms. Climacteric 2004;7(2):165-74.
Beral V, Reeves G, Banks E. Current evidence about the effect of hormone replacement therapy on the incidence of major conditions in postmenopausal women. BJOG 2005;112(6):692-5.
Abedzadeh Kalarhoudi M, Taebi M, Sadat Z, Saberi F. Assessment of quality of life in menopausal periods: A population study in Kashan, Iran. Iran Red Crescent Med J 2011;13(11):811-7.
Bouzari Z, Kotaneie MJ, Darzi AA, Hajian K. Menopausal symptom can be influenced by various sociodemographic factor and Qol Decrease after menopause. World Appl Sci J 2013;23(9):1221-30.
Hong KW, Ko KP, Ahn Y, Kim CS, Park SJ, Park JK, et al. Epidemiological profiles between equol producers and nonproducers: A genomewide association study of the equol-producing phenotype. Genes Nutr 2012;7(4):567-74.
Song KB, Atkinson C, Frankenfeld CL, Jokela T, Wähälä K, Thomas WK, et al. Prevalence of daidzein-metabolizing phenotypes differs between Caucasian and Korean American women and girls. J Nutr 2006;136(5):1347-51.
Setchell KD, Brown NM, Summer S, King EC, Heubi JE, Cole S, et al. Dietary factors infuence production of the soy isoflavone metabolite S-(-)equol in healthy adults. J Nutr 2013;143(12):1950-8.
Botefilia. Outcome Post Daidzein Isoflavone Supplementation in Th1/2 Cytokine Level: TNFa, IL 4, IL 6, and IL 10 in Post Menopausal Women Equol Producer and Non Equol Producer. Tesis; 2015. p. 98-9.
Niyva A, Raja K, Kumaravel M, Sasidharan S, Seethapathy GS. Role of Nutraceutical in cancer. Int J Pharm Pharm Sci 2012;4 Suppl 4:415-20.
Ikegami S, Tousen Y, Ishimi Y. Possible adverse effect of soy isoflavone mixture on pregnant and lactating rats and their suckling pups. J Health Sci 2006;52(5):558-67.
Marmitt DJ, Bitencourt S, Silva AD, Goettert MI, Rempel C. Medicinal plants of Renisius with analgesic activity. J Crit Rev 2016;3(3):1-4.
Basaria S, Wisniewski A, Dupree K, Bruno T, Song MY, Yao F, et al. Effect of high-dose isoflavones on cognition, quality of life, androgens, and lipoprotein in post-menopausal women. J Endocrinol Invest 2009;32(2):150-5.
Phipl HA. Hot flashes: A review of literature on alternative and complementary treatment. Altern Med Rev 2003;8(3):284-302.
Harrison JJ, Dankyi E, Kingsford-Adaboh R, Ishida H. Search of new leads: A closer look at the therapeutic potential of the constituents of Millettia thonningii, Millettia pachycarpa and their structural analogues. Int J Pharm Pharm Sci 2011;3(2):71-81.
Published
How to Cite
Issue
Section
The publication is licensed under CC By and is open access. Copyright is with author and allowed to retain publishing rights without restrictions.
