FORMULATION AND EVALUATION OF GASTRORETENTIVE DRUG DELIVERY SYSTEM CONTAINING COMBINATION OF GLIPIZIDE AND METFORMIN HYDROCHLORIDE
DOI:
https://doi.org/10.22159/ajpcr.2016.v9i6.14286Abstract
The purpose of gastro-retentive drug delivery systems was special focus on the principle mechanism of floatation to achieve gastric retention. The objective is to develop a gastro-retentive drug delivery system of Glipizide and Metformine hydrochloride is to overcome the biggest problem in oral drug delivery is low and erratic drug bioavailability. Glipizide and Metformine hydrochloride are used for the treatment of diabetes mellitus. Seven formulations containing retardant material and alkalizing agent were prepared with solubilizing agent in different ratio. The ability of various polymers to retain the drug when used in different concentrations was investigated. It was found that sodium bicarbonate reacts with HCl and produce CO2 which creates pores in tablet and elevates swelling by wetting polymer. So it helps in maintaining the buoyancy. The release rate could be modified by varying the polymer ratio, concentration of alkalizing and solubilizing agent. The prepared tablets were evaluated for general appearance, content uniformity, hardness, friability, buoyancy and in vitro dissolution studies.
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References
Nayak AK, Maji R, Das B. Gastroretentive drug delivery system. Asian J Pharm Clin Res 2010;3(1):1-2.
Raja BD, Thakkar HR, Paramasivam S, Jamsheer AK, Adimoolam S. Formulation and evalution of gastroretentive floating tablets of glipizide. Int J Res Ayur Pharm 2011;2(3):911-7.
Dave BS, Amin AF, Patel MM. Gastroretentive drug delivery system of ranitidine hydrochloride: Formulation and in vitro evaluation. AAPS Pharm Sci Tech 2004;5(2):e34.
Prajapati ST, Patel LD, Patel DM. Studies on formulation and in vitro evaluation of floating matrix tablets of domperidone. Indian J Pharm Sci 2009;71(1):19-23.
Gohel MC, Mehta PR, Dave RK, Bariya NH. More relevant dissolution method for evalution of floating drug delivery system. Dissol Technol 2005;22-5.
Joseph NJ, Lakshmi S, Jayakrishnan A. A floating-type oral dosage form for piroxicam based on hollow polycarbonate microspheres: In vitro and in vivo evaluation in rabbits. J Control Release 2002;79(1-3):71-9.
Gohel MC, Mehta PR, Dave KR. A more relevant method for evaluation of floating drug delivery system. Dissol Technol 2004;22:5.
Vedha HB, Brahma RA, Samyuktha RB. Floating drug delivery of nevirapine as a gastroretentive system. J Young Pharm 2010;2(4):350-5.
Available from: http//www.slideboom.com/presentation/288556/Methods to evaluate the compability of drug with exipients. [Last accessed on 2015 Feb 02].
Kulkarni AP, Jaiswal M, Jawale BS, Shirolkar SV, Kasture PV. Development and evaluation of press-coated tablets for chronotherapeutical drug delivery using gellable and permeable polymer. Der Pharma Lett 2010;2(4):482-97.
Government of India, Ministry of Health and Family Welfare. Indian Pharmacopeia. Vol.2. Ghaziabad: The Indian Pharmacopoeia Commission; 1996. p. 659-61.
El-Kamel AH, Sokar MS, Al Gamal SS, Naggar VF. Preparation and evaluation of ketoprofen floating oral delivery system. Int J Pharm 2001;220(1-2):13-21.
Basak SC, Rahman J, Ramalingam M. Design and in vitro testing of a floatable gastroretentive tablet of metformin hydrochloride. Pharmazie 2007;62(2):145-8.
Hui M, Ozkan Y. Bilayer buoyant tablet consisting one immediate release layer and one sustained release layer. Drug Dev Ind Pharm 2000;26(8):857-66.
Wu W, Zhou Q, Zhang HB, Ma GD, Fu CD. Studies on nimodipine sustained-release tablet capable of floating on gastric fluid with prolonged gastric resident time. Yao Xue Xue Bao 1997;32(10):786-90.
Moursy NM, Afifi NN, Ghorab DM, El-Saharty Y. Formulation and evaluation of sustained release floating capsules of nicardipine hydrochloride. Pharmazie 2003;58(1):38-43.
Hou SY, Cowles VE, Berner B. Gastric retentive dosage forms: A review. Crit Rev Ther Drug Carrier Syst 2003;20(6):459-97.
Steingoetter A, Kunz P, Weishaupt D, Mäder K, Lengsfeld H, Thumshirn M, et al. Analysis of the meal-dependent intragastric performance of a gastric - retentive tablet assessed by magnetic resonance imaging. Aliment Pharmacol Ther 2003;18(7):713-20.
The European Agency for the Evaluation of Medical Products, ICH Topic Q2B Note for Guidance on Validation of Analytical Procedures: Methodology GPMP/ICH/281/95. Geneva, Switzerland: IFPMA; 1996. p. 1-8.
Umamaheswari RB, Jain S, Tripathi PK, Agrawal GP, Jain NK. Floating-bioadhesive microspheres containing acetohydroxamic acid for clearance of Helicobacter pylori. Drug Deliv 2002;9(4):223-31.
Nur AO, Zhang JS. Captopril floating and/or bioadhesive tablets: Design and release kinetics. Drug Dev Ind Pharm 2000;26(9):965-9.
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