EVALUATION OF CYCLIC ADENOSINE MONOPHOSPHATE AND NEUROTRANSMITTERS IN EXPERIMENTAL OBESITY: IMPACT OF BLACK PEPPER AND COFFEE AQUEOUS EXTRACTS
DOI:
https://doi.org/10.22159/ajpcr.2016.v9s3.14592Abstract
ABSTRACT
Objective: This study aims to evaluate the effect of black pepper and coffee extracts on chronic and acute experimental-induced obesity and energy
homeostasis.
Methods: Rats were divided into 10 groups including control, high-fat diet (HFD), triton, HFD+triton, black pepper+HFD, black pepper+HFD+triton,
coffee+HFD, coffee+HFD+triton, mixture+HFD, and mixture+HFD+triton groups. Blood glucose, serum insulin, and insulin resistance were estimated.
Body mass index, food efficiency intake, and body weight gain were calculated. Lipid profile, liver and kidney functions were measured, serum and brain
cyclic adenosine monophosphate (cAMP) was estimated, and brain neurotransmitters were measured by high-performance liquid chromatography.
Furthermore, histopathology of liver was performed.
Results: Findings showed that blood glucose, insulin resistance, lipid profile, kidney and liver functions as well as brain cAMP and neurotransmitters
were significantly increased, concomitant with a significant decrease in insulin resistance and serum cAMP in both HFD and triton-induced obesity
groups compared to control.
Conclusion: Supplementation with black pepper extract, coffee extract, and a mixture of both significantly improved these findings. In conclusion,
black pepper and coffee extracts are overlooked as promising weight reduction and antihyperlipidemic agents.
Keywords: Energy homeostasis, Obesity, Black pepper extract, Coffee extract, Cyclic adenosine monophosphate, Neurotransmitters.
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References
Guyenet SJ, Schwartz MW. Clinical review: Regulation of food intake, energy balance, and body fat mass: Implications for the pathogenesis and treatment of obesity. J Clin Endocrinol Metab 2012;97(3):745-55.
Ebbert JO, Jensen MD. Fat depots, free fatty acids, and dyslipidemia. Nutrients 2013;5(2):498-508.
Aziz N, Mehmood MH, Siddiqi HS, Mandukhail SU, Sadiq F, Maan W, et al. Antihypertensive, antidyslipidemic and endothelial modulating activities of Orchis mascula. Hypertens Res 2009;32:997-1003.
Adeneye AA, Crooks PA. Weight losing, antihyperlipidemic and cardioprotective effects of the alkaloid fraction of Hunteria umbellata seed extract on normal and triton-induced hyperlipidemic rats. Asian Pac J Trop Biomed 2015;5(5):387-94.
Gregor MF, Hotamisligil GS. Inflammatory mechanisms in obesity. Annu Rev Immunol 2011;29:415-45.
Benzler J, Ganjam GK, Pretz D, Oelkrug R, Koch CE, Legler K, et al. Central inhibition of IKKß/NF-?B signaling attenuates high-fat diet-induced obesity and glucose intolerance. Diabetes 2015;64(6):2015-27.
Cortez M, Carmo LS, Rogero MM, Borelli P, Fock RA. A high-fat diet increases IL-1, IL-6, and TNF-a production by increasing NF-?B and attenuating PPAR-? expression in bone marrow mesenchymal stem cells. Inflammation 2013;36(2):379-86.
Guri AJ, Hontecillas R, Bassaganya-Riera J. Abscisic acid synergizes with rosiglitazone to improve glucose tolerance and down-modulate macrophage accumulation in adipose tissue: Possible action of the cAMP/PKA/PPAR ? Axis. Clin Nutr 2010;29(5):646-53.
Zhang C, Wang G, Zheng Z, Maddipati KR, Zhang X, Dyson G, et al. Endoplasmic reticulum-tethered transcription factor cAMP responsive element-binding protein, hepatocyte specific, regulates hepatic lipogenesis, fatty acid oxidation, and lipolysis upon metabolic stress in mice. Hepatology 2012;55(4):1070-82.
Langeberg LK, Scott JD. Signalling scaffolds and local organization of cellular behaviour. Nat Rev Mol Cell Biol 2015;16(4):232-44.
Yan J, Mei FC, Cheng H, Lao DH, Hu Y, Wei J, et al. Enhanced leptin sensitivity, reduced adiposity, and improved glucose homeostasis in mice lacking exchange protein directly activated by cyclic AMP isoform 1. Mol Cell Biol 2013;33(5):918-26.
Hasani-Ranjbar S, Larijani B. Medicinal plants as potential new target drugs in endocrine disorders - Review article. Iran J Publ Health 2014;43(1):24-34.
Hasani-Ranjbar S, Jouyandeh Z, Abdollahi M. A systematic review of anti-obesity medicinal plants - An update. J Diabetes Metab Disord 2013;12(1):28.
Panza F, Solfrizzi V, Barulli MR, Bonfiglio C, Guerra V, Osella A, et al. Coffee, tea, and caffeine consumption and prevention of late-life cognitive decline and dementia: A systematic review. J Nutr Health Aging 2015;19(3):313-28.
Bai X, Zhang W, Chen W, Zong W, Guo Z, Liu X. Antihepatotoxic and antioxidant effects of extracts from Piper nigrum L. root. Afr J Biotechol 2011;10(2):267-72.
Yoon YC, Kim SH, Kim MJ, Yang HJ, Rhyu MR, Park JH. Piperine, a component of black pepper, decreases eugenol-induced cAMP and calcium levels in non-chemosensory 3T3-L1 cells. FEBS Open Bio 2014;5:20-5.
Do MT, Kim HG, Choi JH, Khanal T, Park BH, Tran TP, et al. Antitumor efficacy of piperine in the treatment of human HER2-overexpressing breast cancer cells. Food Chem 2013;141(3):2591-9.
Rasheed M, Afshan F, Tariq RM, Siddiqui BS, Gulzar T, Mahmood A, et al. Phytochemical studies on the seed extract of Piper nigrum Linn. Nat Prod Res 2005;19(7):703-12.
Mahdy K, Shaker O, Wafay H, Nassar Y, Hassan H, Hussein A. Effect of some medicinal plant extracts on the oxidative stress status in Alzheimer’s disease induced in rats. Eur Rev Med Pharmacol Sci 2012;16(l3):31-42.
Rezq AA, Fathy NM. Effect of regular drinking of boiled, filtered or Turkish coffee and its impact on some biochemical parameters relevant to atherogenicity and the functions of the kidney and the liver in rat model. Eur J Sci 2010;2(3):46-54.
Gupta S, Kaushik M. Histomorphologicl and hypolipidaemic effects from whole plant of Gymenma sylvestre in high cafeteria diet-induced obese rat model. J Pharm Biomed Sci 2010;2(2):1-9.
Levine S, Saltzman A. A procedure for inducing sustained hyperlipemia in rats by administration of a surfactant. J Pharmacol Toxicol Methods 2007;55:224-6.
Mishra R, Pandit K, Bhawat AM, Brijesh S. Antihyperlipidemic activity of alcoholic extracts of Trichosanthes anguina in triton Wr 1339 induced hyperlipidemic rats. IJPSR 2014;5(10):4269-74.
Ahmed HA, Salem MH, Sabry GM, Husein HA, Kotob SE. New insights in the horizon for the treatment of Alzheimer’s disease: A proposal based on experimental study. Der Pharm Lett 2015;7(2):165-82.
Mannaa F, Ahmed HH, Estefan SF, Sharaf HA, Eskander EF. Saccharomyces cerevisiae intervention for relieving flutamide-induced hepatotoxicity in male rats. Pharmazie 2005;60:689-95.
Trinder P. Determination of blood glucose using an oxidase-peroxidase system with a non-carcinogenic chromogen. J Clin Pathol 1969;22(2):158-61.
Reitman S, Frankel S. A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases. Am J Clin Pathol 1957;28(1):56-63.
Kaplan A. Urea. In: Kaplan LA, Pesce AJ, editors. Clinical Chemistry: Theory, Analysis and Correlation. St. Louis, Miss.: Mosby; 1984. p. 1257-60.
Fabiny DL, Ertinghausen G. Automated reaction-rate method for determination of serum creatinine with the Centrifuge. Clin Chem 1971;17(8):696-700.
Meiattini F, Prencipe L, Bardelli F, Giannini G, Tarli P. The 4-hydroxybenzoate/4-aminophenazone chromogenic system used in the enzymic determination of serum cholesterol. Clin Chem 1978;24(12):2161-5.
Bucolo G, David H. Quantitative determination of serum triglycerides by the use of enzymes. Clin Chem 1973;19(5):476-82.
Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972;18(6):499-502.
Yalow R, Bauman WA. Insulin in health and disease. In: Ellenberg M, Rifkin H, editors. Diabetes Mellitus: Theory and Practice. New York: Excerpta Medica; 1983. p. 119-50.
Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985;28(7):412-9.
McDaniel FK, Molden BM, Mohammad S, Baldini G, McPike L, Narducci P, et al. Constitutive cholesterol-dependent endocytosis of melanocortin-4 receptor (MC4R) is essential to maintain receptor responsiveness to α-melanocyte-stimulating hormone (α-MSH). J Biol Chem 2012;287(26):21873-90.
Hussein J, Abo EL-Matty D, El-Khayat Z, Abdel-Latif Y. Brain neurotransmitters in diabetic rats treated with coenzyme Q10. Int J Pharm Pharm Sci 2012;4 Suppl 4:554-6.
Drury RA, Wallington EA. Carleton’s Histological Technique. 4th ed. Oxford: Oxford University Press; 1980.
Manmontri B, Sariahmetoglu M, Donkor J, Bou Khalil M, Sundaram M, Yao Z, et al. Glucocorticoids and cyclic AMP selectively increase hepatic lipin-1 expression, and insulin acts antagonistically. J Lipid Res 2008;49(5):1056-67.
Ismail TA, Soliman MM, Nassan MA, Mohamed DI. Antihypercholesterolemic effects of mushroom, chrysin, curcumin and omega-3 in experimental hypercholesterolemic rats. J Food Nutr Res 2015;3(2):77-87.
McQuaid SE, Hodson L, Neville MJ, Dennis AL, Cheeseman J, Humphreys SM, et al. Downregulation of adipose tissue fatty acid trafficking in obesity: A driver for ectopic fat deposition? Diabetes 2011;60(1):47-55.
Aziz N, Mehmood MH, Gilani AH. Studies on two polyherbal formulations (ZPTO and ZTO) for comparison of their antidyslipidemic, antihypertensive and endothelial modulating activities. BMCComplement Altern Med 2013;13:371.
Sahu M, Anamthathmakula P, Sahu A. Phosphodiesterase-3B-cAMP pathway of leptin signalling in the hypothalamus is impaired during the development of diet-induced obesity in FVB/N mice. J Neuroendocrinol 2015;27(4):293-302.
Ohyama K, Nogusa Y, Suzuki K, Shinoda K, Kajimura S, Bannai M. A combination of exercise and capsinoid supplementation additively suppresses diet-induced obesity by increasing energy expenditure in mice. Am J Physiol Endocrinol Metab 2015;308(4):E315-23.
Li B, Lang N, Cheng ZF. Serum levels of brain-derived neurotrophic factor are associated with diabetes risk, complications, and obesity: A cohort study from Chinese patients with type 2 diabetes. Mol Neurobiol 2016;53(8):5492-9.
Gotthardt JD, Verpeut JL, Yeomans BL, Yang JA, Yasrebi A, Roepke TA, et al. Intermittent fasting promotes fat loss with lean mass retention, increased hypothalamic norepinephrine content, and increased neuropeptide Y gene expression in diet-induced obese male mice. Endocrinology 2016;157(2):679-91.
Jabbour G, Lemoine-Morel S, Casazza GA, Hala Y, Moussa E, Zouhal H. Catecholamine response to exercise in obese, overweight, and lean adolescent boys. Med Sci Sports Exerc 2011;43(3):408-15.
Meireles M, RodrÃguez-Alcalá LM, Marques C, Norberto S, Freitas J, Fernandes I, et al. Effect of chronic consumption of blackberry extract on high-fat induced obesity in rats and its correlation with metabolic and brain outcomes. Food Funct 2016;7(1):127-39.
Carlin J, Hill-Smith TE, Lucki I, Reyes TM. Reversal of dopamine system dysfunction in response to high-fat diet. Obesity (Silver Spring) 2013;21(12):2513-21.
Jean A, Conductier G, Manrique C, Bouras C, Berta P, Hen R, et al. Anorexia induced by activation of serotonin 5-HT4 receptors is mediated by increases in CART in the nucleus accumbens. Proc Natl Acad Sci U S A 2007;104(41):16335-40.
Kim JH, Choi JH. Pathophysiology and clinical characteristics of hypothalamic obesity in children and adolescents. Ann Pediatr Endocrinol Metab 2013;18(4):161-7.
Egawa T, Hamada T, Ma X, Karaike K, Kameda N, Masuda S, et al. Caffeine activates preferentially a1-isoform of 5’AMP-activated protein kinase in rat skeletal muscle. Acta Physiol (Oxf) 2011;201(2):227-38.
Bhaktha G, Shantaram M, Nayak S. Beneficial effects of coffee and maintenance of uric acid levels. Int J Pharm Pharm Sci 2016;8(4)(4):393-5.
Chioma OO, Victor NO, Emeka GA. Effect of piper nigrum Leaves extract on lipid profile status on alloxan induced diabetic rats. World Appl Sci J 2014;32(1):34-9.
Huang CC, Tung YT, Huang WC, Chen YM, Hsu YJ, Hsu MC. Beneficial effects of cocoa, coffee, green tea, and garcinia complex supplement on diet induced obesity in rats. BMC Complement Altern Med 2016;16:100.
Vitaglione P, Morisco F, Mazzone G, Amoruso DC, Ribecco MT, Romano A, et al. Coffee reduces liver damage in a rat model of steatohepatitis: The underlying mechanisms and the role of polyphenols and melanoidins. Hepatology 2010;52(5):1652-61.
Wu T, Willett WC, Hankinson SE, Giovannucci E. Caffeinated coffee, decaffeinated coffee, and caffeine in relation to plasma C-peptide levels, a marker of insulin secretion, in U.S. women. Diabetes Care 2005;28(6):1390-6.
Sharma G, Mishra B. Piperine - A therapeutic agent and bioavalibility enhancer. J Pharm Res 2007;6:129-33.
Heilbronn LK, Clifton PM. C-reactive protein and coronary artery disease: Influence of obesity, caloric restriction and weight loss. J Nutr Biochem 2002;13(6):316-21.
Reyes-Izquierdo T, Argumedo R, Shu C, Nemzer B, Pietrzkowski ZB. Stimulatory effect of whole coffee fruit concentrate powder on plasma levels of total and exosomal brain-derived neurotrophic factor in healthy subjects: An acute within-subject clinical study. Food Nutr Sci 2013;4:984-90.
Li G, Ruan L, Chen R, Wang R, Xie X, Zhang M, et al. Synergistic antidepressant-like effect of ferulic acid in combination with piperine: Involvement of monoaminergic system 2015;30(6):1505-14.
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