CORRELATION STUDY OF DISEASE ACTIVITY SCORE AND SERUM CARTILAGE OLIGOMERIC MATRIX PROTEINLEVELS OF RHEUMATOID ARTHRITIS PATIENTS IN BANDUNG, INDONESIA

Nyi Mekar Saptarini; Dainar Eka Pratiwi; Ellin Febrina; Marlia Singgih Wibowo; Tutus Gusdinar

doi:10.22159/ajpcr.2017.v10i1.15251

Authors

Nyi Mekar Saptarini Padjadjaran University
Dainar Eka Pratiwi Universitas Padjadjaran
Ellin Febrina Universitas Padjadjaran
Marlia Singgih Wibowo Institut Teknologi Bandung
Tutus Gusdinar Institut Teknologi Bandung

DOI:

https://doi.org/10.22159/ajpcr.2017.v10i1.15251

Abstract

Objective: This study was designed to determine the correlation between Disease Activity Score (DAS 28) and the serum Cartilage Oligomeric Matrix Protein (COMP) levels in Indonesian Rheumatoid Arthritis (RA) patients.

Methods: The subjects were patients who visit the rheumatology clinic at one governmental hospital in Bandung, Indonesia. DAS was determined by the QxMD Software based on erythrocyte sedimentation rate, and serum COMP levels were determined by enzyme-linked immunosorbent assay. Statistical analysis was conducted with IBM SPSS Statistics 23.

Results: DAS 28 value was 3.36 Â± 0.16 which indicates the moderate disease activity. Serum COMP levels were 843.80 Â± 35.79 ng/ml in RA patients and 830.00 Â± 48.92 ng/ml in normal controls.

Conclusion: There is no correlation between DAS 28 and serum COMP levels in RA patients (p = 0.496 and rho = 0.129).

Keywords: Autoimmune disease, Rheumatoid arthritis monitoring, Cartilage oligomeric matrix protein, Disease activity score 28

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Author Biographies

Nyi Mekar Saptarini, Padjadjaran University

Faculty of Pharmacy

Dainar Eka Pratiwi, Universitas Padjadjaran

Faculty of Pharmacy

Ellin Febrina, Universitas Padjadjaran

Faculty of Pharmacy

Marlia Singgih Wibowo, Institut Teknologi Bandung

School of Pharmacy

Tutus Gusdinar, Institut Teknologi Bandung

School of Pharmacy

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