THROMBOLYTIC ACTIVITY OF C.AMADA AND C.CAESIA
DOI:
https://doi.org/10.22159/ajpcr.2017.v10i2.15694Abstract
Objective: To compare the thrombolytic activity of C.amada and C. caesia.
Methods: Hydro alcoholic extractions of C.amada and C. caesia were prepared. Clot lysis potential of the extracts was checked and the results were statistically analysed.
Result and Conclusion: On comparing the thrombolytic potential, the % of clot lysis of silver nanoparticle synthesized using C. caesia (51%) was found to be higher than C.amada (34.7%) extract. Similarly C. caesia extract (38.75 ± 2.217) showed higher % of clot lysis than C.amada (34.74 ± 6.074). The mean percentage of clot lysis of rhizome extracts and synthesized silver nanoparticle were statistically more significant (p value < 0.05) when compared to the positive control streptokinase and negative control water. Active component involvement analysis will be helpful to utilize the C.amada and C. caesia as potent therapeutic agent.
Key words: C.amada, C. caesia, thrombolytic potential.
Downloads
References
Bassam Abdul Rasool Hassan. Medicinal Plants (Importance and Uses), Pharmaceut Anal Acta 2012; 3:10.
Konickal Mambetta Prabhu Kumar, Gopinathan Ramanikutty Asish, Mamiyil Sabu and Indira Balachandran. Significance of gingers (Zingiberaceae) in Indian System of Medicine - Ayurveda: An overview. Anc Sci Life 2013; 32(4): 253–261.
Shakeel Ahmad Jatoi, Akira Kikuchi, Dawood Ahmad, Kazuo N. Watanabe. Characterization of the genetic structure of mango ginger (Curcuma amada Roxb.) from Myanmar in farm and genebank collection by the neutral and functional gesnomic markers, Electronic journal of Biotechnology 2010; 13(6).
Jeke Kullu, Abhishek Dutta, Denis Constales, Surabhi Chaudhuri, Debjani Dutta. Experimental and modeling studies on microwave-assisted extraction of mangiferin from Curcuma amada, 3Biotech 2014; 4(2):107-120.
A.R. Zuraida. Improved in vitro propagation of Curcuma caesia, a valuable medicinal plant, J. Trop. Agric. And Fd.Sc. 2013; 41(2):273-281.
Arghya Ghosh, Ayan Bandyopadhyay, Parthadeb Ghosh, Padma Chatterjee. Isolation of a novel terpenoid from the rhizome of Curcuma caesia Roxb. Journal of Scientific and innovative research 2013; 2(4): 777- 784.
Kananbala Sarangthem and Mangvung Jamkhoneng Haokip. Bioactive components in Curcuma caesia roxb. Grown in Manipur, The Bioscan 2010; 5(1): 113- 115.
Karol Kramkowski, Agnieszka Leszczynska, Wlodzimierz Buczko. Pharmacological modulation of fibrinolytic response – In vivo and in vitro studies, Pharmacological Reports 2015; 67(4): 695- 703.
K. C. Gersh, S. Zaitsev, V. Muzykantov,D. B. Cines, and J. W. Weisel. The spatial dynamics of fibrin clot dissolution catalyzed by erythrocyte-bound vs. free fibrinolytics, J Thromb Haemos 2010; 8(5): 1066- 1074.
Umesh M K, Sanjeevkumar C B, Hanumantappa bherigi nayaka and Ramesh l londonkar. Evaluation of in vitro anti-thrombolytic activity and cytotoxicity potential of typha angustifolia leaves extract, Int j pharm science 2014; 6(5): 81- 85.
Korbekandi H, Chitsazi MR, Asghari G, Bahri Najafi R, Badii A, Iravani S. Green biosynthesis of silver nanoparticles using Quercus brantii (oak) leaves hydroalcoholic extract, Pharm Biol 2015; 53(6):807- 12.
Ali Ramjan, Marjan Hossain, Jannatul Ferdous Runa, Hasanuzzaman Md, and Islam Mahmodul. Evaluation of thrombolytic potential of three medicinal plants available in Bangladesh, as a potent source of thrombolytic compounds, Avicenna J Phytomed 2014; 4(6): 430-436.
Talha Bin Emran, Md Atiar Rahman, Mir Muhammed Nasir Uddin, Md Mominur Rahman, Md Zia Uddin, Raju Dash and Chadny Layzu. Effects of organic extracts and their different fractions of five Bangladeshi plant in vitro thrombolysis, BMC complementary and alternative Medicine 2015; 15: 128.
S. Vijaya Bharathi, Ali Ahmad and Sani Mohammed Tajo. Silver nanoparticle using c.caesia and c.amada rhizome extract, International journal of PharmTech Research 2015;8(7):142-145.
Ilinskaya AN, Dobrovolskaia MA. Nanoparticles and the blood coagulation system. Part I: benefits of nanotechnology. Nanomed. 2013;8:773–784.
Agbaje Lateef, Monsurat A. Akande, Sunday A. Ojo, Bolaji I. Folarin, Evariste B. Gueguim-Kana, and Lorika S. Beukes. Paper wasp nest-mediated biosynthesis of silver nanoparticles for antimicrobial, catalytic, anticoagulant, and thrombolytic applications, 3 Biotech 2016; 6(2): 140.
Kirankumar Shivasharanappa and Ramesh Londonkar. Clot lysis and Antimitotic study of Ficus glomerataRoxb fruit extract, ISRN Pharmacology 2014.
Published
How to Cite
Issue
Section
The publication is licensed under CC By and is open access. Copyright is with author and allowed to retain publishing rights without restrictions.
