APPLICABILITY OF NANOPARTICLES-HYDROGEL COMPOSITE IN TREATING PERIODONTAL DISEASES AND BEYOND
DOI:
https://doi.org/10.22159/ajpcr.2017.v10i2.15709Abstract
Nanoparticles-Hydrogel Composite (nanogels) have yielded a surge in the design and development of novel drug delivery systems for the treatment of many ailments, including periodontal disease. The recent innovations in nanotechnological drug carrier systems seem promising, as it provides a means to improve the bioavailability of poorly soluble drugs, formulations of controlled and targeted drug delivery systems, drug release control base on the stimuli response, among others. Several polymeric nanoparticles-hydrogel co-formulations have been investigated during the last few years, mostly using synthetic & natural polymers. Some of the results and rewards achieved from these novel approaches are the use of bioadhesive polymers to achieve prolong drug release, the increment of intra-pocket drug penetration, the enhancement of mechanical properties using chemical crosslinkers and the possibility of loading multiple drugs in a unit delivery system. Furthermore, these nanotechnological advances have also shown that nanoparticles (NPs) possess great potential as drug carriers in periodontal disease treatment. The future utilization of these advantages will significantly improve dental care. The co-formulation of nanoparticles-hydrogel composite will yield additional benefits that are much greater than ordinary NPs or hydrogels in delivering of drug into the periodontal pockets. The aim of this review article is to summarises updates on the current and future nanotechnological approaches that are being investigated for the treatment of periodontitis, with particular attention to the nanogels, and to identify arenas which its exploration might lead to the development of an effective intra-pocket drug delivery systems for the treatment of periodontal diseases. The review also provided brief applications of nanogels in the management of other diseases.
Keywords: Nanocomposite, Hydrogels, Nanoparticles, Nanogels, Periodontal intra-pocket drug delivery system, Nanotechnological approaches.
Downloads
References
Pihlstrom BL, Michalowicz BS, Johnson NW. Periodontal diseases.
Lancet 2005;366(9499):1809-20.
Jain N, Jain GK, Javed S, Iqbal Z, Talegaonkar S, Ahmad FJ, et al.
Recent approaches for the treatment of periodontitis. Drug Discov
Today 2008;13(21-22):932-43.
Page RC, Schroeder HE. Pathogenesis of inflammatory periodontal
disease. A summary of current work. Lab Invest 1976;34(3):235-49.
Savage A, Eaton KA, Moles DR, Needleman I. A systematic review of
definitions of periodontitis and methods that have been used to identify
this disease. J Clin Periodontol 2009;36(6):458-67.
Aminu N, Baboota S, Pramod K, Singh M, Dang S, Ansari SH, et al.
Development and evaluation of triclosan loaded poly-ε-caprolactone
nanoparticulate system for the treatment of periodontal infections.
J Nanopart Res 2013;15(11):2075.
Wilczewska AZ, Niemirowicz K, Markiewicz KH, Car H. Nanoparticles
as drug delivery systems. Pharmacol Rep 2012;64(5):1020-37.
Piñón-Segundo E, Ganem-Quintanar A, Alonso-Pérez V,
Quintanar-Guerrero D. Preparation and characterization of triclosan
nanoparticles for periodontal treatment. Int J Pharm 2005;294(12):217-32.
Wu H, Yu G, Pan L, Liu N, McDowell MT, Bao Z, et al. Stable
Li-ion battery anodes by in-situ polymerization of conducting hydrogel
to conformally coat silicon nanoparticles. Nat Commun 2013;4:1943.
Pichayakorn W, Boonme P. Evaluation of cross-linked chitosan
microparticles containing metronidazole for periodontitis treatment.
Mater Sci Eng C Mater Biol Appl 2013;33(3):1197-202.
Jamal T, Rahman MA, Mirza MA, Panda AK, Talegaonkar S, Iqbal Z.
Formulation, antimicrobial and toxicity evaluation of bioceramic based
ofloxacin loaded biodegradable microspheres for periodontal infection.
Curr Drug Deliv 2012;9(5):515-26.
Shanmuganathan S, Shanumugasundaram N, Adhirajan N, Lakshmi TS,
Babu M. Preparation and characterization of chitosan microspheres for
doxycycline delivery. Carbohydr Polym 2008;73(2):201-11.
Esposito E, Cortesi R, Cervellati F, Menegatti E, Nastruzzi C.
Biodegradable microparticles for sustained delivery of tetracycline
to the periodontal pocket: Formulatory and drug release studies.
J Microencapsul 1997;14(2):175-87.
Yue IC, Poff J, Cortés ME, Sinisterra RD, Faris CB, Hildgen P, et al.
A novel polymeric chlorhexidine delivery device for the treatment of
periodontal disease. Biomaterials 2004;25(17):3743-50.
Saboktakin MR, Tabatabaie RM, Maharramov A,
Ramazanov MA. Development and in vitro evaluation of thiolated
chitosan – Poly(methacrylic acid) nanoparticles as a local mucoadhesive
delivery system. Int J Biol Macromol 2011;48(3):403-7.
Kashi TS, Eskandarion S, Esfandyari-Manesh M, Marashi SM,
Samadi N, Fatemi SM, et al. Improved drug loading and antibacterial
activity of minocycline-loaded PLGA nanoparticles prepared by solid/
oil/water ion pairing method. Int J Nanomedicine 2012;7:221-34.
Yao W, Xu P, Pang Z, Zhao J, Chai Z, Li X, et al. Local delivery of
minocycline-loaded PEG-PLA nanoparticles for the enhanced treatment
of periodontitis in dogs. Int J Nanomedicine 2014;9:3963-70.
Khan ST, Al-Khedhairy AA, Musarrat J. ZnO and TiO2 nanoparticles as
novel antimicrobial agents for oral hygiene: A review. J Nanopart Res
;17(6):276.
Ahmed M, Harish N, Charyulu R, Prabhu P. Formulation of
chitosan-based ciprofloxacin and diclofenac film for periodontitis
therapy. Trop J Pharm Res 2009;8(1):33-41.
Hirschfeld Z, Friedman M, Golomb G, Ben-Yaacov D. New sustained
release dosage form of chlorhexidine for dental use: Use for plaque
control in partial denture wearers. J Oral Rehabil 1984;11(5):477-82.
El-Kamel AH, Ashri LY, Alsarra IA. Micromatricial metronidazole
benzoate film as a local mucoadhesive delivery system for treatment of
periodontal diseases. AAPS PharmSciTech 2007;8(3):E75.
Vineetha VC, Mathews MM. Development and evaluation of dental
films containing an antibacterial agent for the treatment of periodontitis.
Int J Pharm Pharm Sci 2015;7(3):52-9.
Mizrak T, Güncü GN, Caglayan F, Balci TA, Aktar GS, Ipek F. Effect of
a controlled-release chlorhexidine chip on clinical and microbiological
parameters and prostaglandin E2 levels in gingival crevicular fluid.
J Periodontol 2006;77(3):437-43.
Addy M, Langeroudi M. Comparison of the immediate effects on the
sub-gingival microflora of acrylic strips containing 40% chlorhexidine,
metronidazole or tetracycline. J Clin Periodontol 1984;11(6):379-86.
Wade WG, Moran J, Morgan JR, Newcombe R, Addy M. The effects
of antimicrobial acrylic strips on the subgingival microflora in chronic
periodontitis. J Clin Periodontol 1992;19(2):127-34.
Taner IL, Ozcan G, DoÄŸanay T, Iscanolu M, TaplamacioÄŸlu B,
Gültekin SE, et al. Comparison of the antibacterial effects on
subgingival microflora of two different resorbable base materials
containing doxycycline. J Nihon Univ Sch Dent 1994;36(3):183-90.
Popa L, Ghica MV, Dinu-Pîrvu CE. Periodontal chitosan-gels
designed for improved local intra-pocket drug delivery. Farmacia
;61(2):240-50.
Akncbay H, Senel S, Ay ZY. Application of chitosan gel in the treatment
of chronic periodontitis. J Biomed Mater Res B Appl Biomater
;80(5):290-6.
Raheja I, Kohli K, Drabu S. Periodontal drug delivery system containing
antimicrobial agents. Int J Pharm Pharm Sci 2013;5(3):11-6.
Coventry J, Newman HN. Experimental use of a slow release device
employing chlorhexidine gluconate in areas of acute periodontal
inflammation. J Clin Periodontol 1982;9(2):129-33.
Bromberg LE, Buxton DK, Friden PM. Novel periodontal drug
delivery system for treatment of periodontitis. J Control Release
;71(3):251-9.
Gardiner J, Freeman S, Leach M, Green A, Alcock J, D’Emanuele A.
PAMAM dendrimers for the delivery of the antibacterial Triclosan.
J Enzyme Inhib Med Chem 2008;23(5):623-8.
Gad HA, El-Nabarawi MA, Abd El-Hady SS. Formulation and
evaluation of PLA and PLGA in situ implants containing secnidazole
and/or doxycycline for treatment of periodontitis. AAPS PharmSciTech
;9(3):878-84.
Chiappetta DA, Degrossi J, Teves S, D’Aquino M, Bregni C, Sosnik A.
Triclosan-loaded poloxamine micelles for enhanced topical antibacterial
activity against biofilm. Eur J Pharm Biopharm 2008;69(2):535-45.
Bhavikatti SK, Bhardwaj S, Prabhuji ML. Current applications of
nanotechnology in dentistry: A review. Gen Dent 2014;62(4):72-7.
Bhardwaj A, Bhardwaj A, Misuriya A, Maroli S, Manjula S, Singh AK.
Nanotechnology in dentistry: Present and future. J Int Oral Health
;6(1):121-6.
Bidwai VS, Rane PS, Talele SG, Jadhav A. Nanogel: A versatile targeted
drug delivery system. Indo Am J Pharm Res 2015;5(12):3905-13.
Hamidi M, Rostamizadeh K, Shahbazi MA. Hydrogel nanoparticles in
drug delivery. In: Intelligent Nanomaterials. Hoboken, NJ, USA: John
Wiley & Sons, Inc.; 2012. p. 583-624.
Pedrosa SS, Gonçalves C, David L, Gama M. A novel crosslinked
hyaluronic acid nanogel for drug delivery. Macromol Biosci
;14(11):1556-68.
Yao Y, Xia M, Wang H, Li G, Shen H, Ji G, et al. Preparation and
evaluation of chitosan-based nanogels/gels for oral delivery of
myricetin. Eur J Pharm Sci 2016;91:144-53.
Sarangi MK, Padhi S. Solid lipid nanoparticles - A review. J Crit Rev
;3(3):5-12.
Bako J, Szepesi M, Veres AJ, Cserhati C, Borbely ZM, Hegedus C,
et al. Synthesis of biocompatible nanocomposite hydrogels as a local
drug delivery system. Colloid Polym Sci 2008;286(3):357-63.
Nagatomo K, Komaki M, Sekiya I, Sakaguchi Y, Noguchi K, Oda S,
et al. Stem cell properties of human periodontal ligament cells.
J Periodontal Res 2006;41(4):303-10.
Hasegawa M, Yamato M, Kikuchi A, Okano T, Ishikawa I. Human
periodontal ligament cell sheets can regenerate periodontal ligament
tissue in an athymic rat model. Tissue Eng 2005;11(3-4):469-78.
Akizuki T, Oda S, Komaki M, Tsuchioka H, Kawakatsu N, Kikuchi A,
et al. Application of periodontal ligament cell sheet for periodontal
regeneration: A pilot study in beagle dogs. J Periodontal Res
;40(3):245-51.
Fukui T, Kobayashi H, Hasegawa U, Nagasawa T, Akiyoshi K,
Ishikawa I. Intracellular delivery of nanogel-quantum dot hybrid
nanoparticles into human periodontal ligament cells. Drug Metab Lett
;1(2):131-5.
Jin HL, Wu W, Shu R. Doxycycline nano-liposome slow-release gel
improves rat periodontitis. Shanghai Kou Qiang Yi Xue 2010;19(5):508-11.
Wang L, Xie X, Imazato S, Weir MD, Reynolds MA, Xu HH.
A protein-repellent and antibacterial nanocomposite for Class-V
restorations to inhibit periodontitis-related pathogens. Mater Sci Eng C Mater Biol Appl 2016;67:702-10.
Trafton A. New Nanogel for Drug Delivery. Massachusetts Institute
of Technology News, 2015. Available from: http://www.news.mit.
edu/2015/self-healing-nanogel-drug-delivery-0219. [Last cited on
Nov 18].
Missirlis D. Development of a Novel Drug Delivery System Based
on Polymeric, Thermoresponsive, Hydrogel Nanoparticles. Ecole
Polytechnique Fédérale de Lausanne (EPFL), 2005. Available from:
http://www.infoscience.epfl.ch/record/54793.
Guo J, Wang Y, Wang J, Zheng X, Chang D, Wang S, et al. A novel
nanogel delivery of poly-α, β-polyasparthydrazide by reverse
microemulsion and its redox-responsive release of 5-fluorouridine.
Asian J Pharm Sci 2016. doi: 10.1016/j.ajps.2016.05.008.
Divya G, Panonnummal R, Gupta S, Jayakumar R, Sabitha M. Acitretin
and aloe-emodin loaded chitin nanogel for the treatment of psoriasis.
Eur J Pharm Biopharm 2016;107:97-109.
Mangalathillam S, Rejinold NS, Nair A, Lakshmanan VK, Nair SV,
Jayakumar R. Curcumin loaded chitin nanogels for skin cancer
treatment via the transdermal route. Nanoscale 2012;4(1):239-50.
Silva JP, Gonçalves C, Costa C, Sousa J, Silva-Gomes R, Castro AG,
et al. Delivery of LLKKK18 loaded into self-assembling hyaluronic acid
nanogel for tuberculosis treatment. J Control Release 2016;235:112-24.
Asadi H, Khoee S. Dual responsive nanogels for intracellular
doxorubicin delivery. Int J Pharm 2016;511(1):424-35.
Zabihi F, Wieczorek S, Dimde M, Hedtrich S, Börner HG, Haag R.
Intradermal drug delivery by nanogel-peptide conjugates; Specific
and efficient transport of temoporfin. J Control Release 2016.
pii: S0168-365930468-0.
Harvey S, Zieve D. Periodontitis: Other Treatments. The New York
Times, 2013. Available from: http://www.nytimes.com/health/
guides/disease/periodontitis/other-treatments.html. [Last cited on
Feb 10].
Munot NM, Gujar KN. Orodental delivery systems: An overview. Int J
Pharm Pharm Sci 2013;5(3):74-83.
Hamidi M, Azadi A, Rafiei P. Hydrogel nanoparticles in drug delivery.
Adv Drug Deliv Rev 2008;60(15):1638-49.
Published
How to Cite
Issue
Section
The publication is licensed under CC By and is open access. Copyright is with author and allowed to retain publishing rights without restrictions.
