A COMPARATIVE STUDY OF RE1-SILENCING TRANSCRIPTION FACTOR (REST) OF TELEOST FISHES

Subhamay Panda; SUVRANIL PODDAR

doi:10.22159/ajpcr.2017.v10i2.15737

Authors

Subhamay Panda Gupta College of Technological Sciences; Indian Institute of Human and Social Sciences (IIHSS).
SUVRANIL PODDAR

DOI:

https://doi.org/10.22159/ajpcr.2017.v10i2.15737

Abstract

Objective: Repressor element 1 (RE1)-silencing transcription factor (REST) is a zinc-finger transcription factor or else can be called as neuron- restrictive silencer factor primarily described as a negative regulator of nuclear differentiation at present known to play key function in neuronal cells.

Methods: With this initial note the aim of this study was to determination of protein sequence level characteristics of REST of Japanese pufferfish

(Takifugu rubripes) and channel catfish (Ictalurus punctatus) with the help of different bioinformatical research tools.

Results: There was no instance of any signal signature present within the amino acid sequence of studied REST molecules. In the present research work protein multiple sequence alignment represented in polarity coloring scheme demonstrates variable sites and as well as conserved sites of proteins in Japanese pufferfish and channel catfish.

Conclusion: The current research analysis clearly manifests that protein evolution occurred within the REST of Japanese pufferfish (Takifugu rubripes) and channel catfish (Ictalurus punctatus).

Keywords: Repressor element 1-silencing transcription factor, Teleost fishes, Japanese pufferfish, Channel catfish, Sequence analysis.

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References

GÃ³mez-Isla T, Price JL, McKeel DW Jr, Morris JC, Growdon JH, Hyman BT. Profound loss of layer II entorhinal cortex neurons occurs in very mild Alzheimerâ€™s disease. J Neurosci 1996;16(14):4491-500.

Peters A, Sethares C, Moss MB. The effects of aging on layer 1 in area 46 of prefrontal cortex in the rhesus monkey. Cereb Cortex

;8(8):671-84.

Yankner BA, Lu T, Loerch P. The aging brain. Annu Rev Pathol

;3:41-66.

Lu T, Aron L, Zullo J, Pan Y, Kim H, Chen Y, et al. REST and stress resistance in ageing and Alzheimerâ€™s disease. Nature

;507(7493):448-54.

Kenyon CJ. The genetics of ageing. Nature 2010;464(7288):504-12.

Spalding KL, Bhardwaj RD, Buchholz BA, Druid H, FrisÃ©n J.

Retrospective birth dating of cells in humans. Cell 2005;122(1):133-43.

Chong JA, Tapia-RamÃrez J, Kim S, Toledo-Aral JJ, Zheng Y, Boutros MC, et al. REST: A mammalian silencer protein that restricts sodium channel gene expression to neurons. Cell 1995;80(6):949-57.

Schoenherr CJ, Anderson DJ. The neuron-restrictive silencer factor (NRSF): A coordinate repressor of multiple neuron-specific genes. Science 1995;267(5202):1360-3.

Ballas N, Grunseich C, Lu DD, Speh JC, Mandel G. REST and its

corepressors mediate plasticity of neuronal gene chromatin throughout neurogenesis. Cell 2005;121(4):645-57.

Schoenherr CJ, Paquette AJ, Anderson DJ. Identification of potential target genes for the neuron-restrictive silencer factor. Proc Natl Acad Sci U S A 1996;93(18):9881-6.

Johnson DS, Mortazavi A, Myers RM, Wold B. Genome-wide mapping of in vivo protein-DNA interactions. Science 2007;316(5830):1497-502.

Wagoner MP, Gunsalus KT, Schoenike B, Richardson AL, Friedl A, Roopra A. The transcription factor REST is lost in aggressive breast cancer. PLoS Genet 2010;6(6):e1000979.

Bruce AW, Donaldson IJ, Wood IC, Yerbury SA, Sadowski MI, Chapman M, et al. Genome-wide analysis of repressor element 1 silencing transcription factor/neuron-restrictive silencing factor (REST/NRSF) target genes. Proc Natl Acad Sci U S A

;101(28):10458-63.

Panda S, Kumari L, Hui S, Panda S. Structural insight of homeobox DNA

binding domain of Hox-B7a protein of Esox lucius. J PharmaSciTech

;6(1):1-4.

Panda S, Chandra G. Physicochemical characterization and functional analysis of some snake venom toxin proteins and related non-toxin proteins of other chordates. Bioinformation 2012;8(18):891-6.

Panda S, Panda S, Kumari L. Molecular modeling and structural analysis of arylesterase of ancylostoma duodenale. Int J Pharma Bio Sci 2016;7(3):B611-6.

Panda S, Chandra G. Sequence analysis and phylogenetic study of some toxin proteins of snakes and related non-toxin proteins of chordates. Bioinformation 2013;9(5):259-66.

NCBI Resource Coordinators. Database resources of the national center for biotechnology information. Nucleic Acids Res 2015;43:D6-17.

Petersen TN, Brunak S, von Heijne G, Nielsen H. SignalP 4.0: Discriminating signal peptides from transmembrane regions. Nat Methods 2011;8(10):785-6.

Larkin MA, Blackshields G, Brown NP, Chenna R, McGettigan PA, McWilliam H, et al. Clustal W and Clustal X version 2.0. Bioinformatics

;23(21):2947-8.

Waterhouse AM, Procter JB, Martin DM, Clamp M, Barton GJ.

Jalview Version 2 â€“ A multiple sequence alignment editor and analysis workbench. Bioinformatics 2009;25(9):1189-91.

Baldelli P, Meldolesi J. The transcription repressor REST in adult neurons: Physiology, pathology, and diseases (1,2,3). eNeuro 2015;2. pii: ENEURO.0010-15.2015.

Schonrock N, Humphreys DT, Preiss T, GÃ¶tz J. Target gene repression mediated by miRNAs miR-181c and miR-9 both of which are down- regulated by amyloid-ÃŸ. J Mol Neurosci 2012;46(2):324-35.

Gopalakrishnan V. REST and the RESTless: In stem cells and beyond.

Future Neurol 2009;4(3):317-29.

Wu J, Xie X. Comparative sequence analysis reveals an intricate network among REST, CREB and miRNA in mediating neuronal gene expression. Genome Biol 2006;7(9):R85.

McClelland S, Brennan GP, DubÃ© C, Rajpara S, Iyer S, Richichi C, et al. The transcription factor NRSF contributes to epileptogenesis by selective repression of a subset of target genes. Elife 2014;3:e01267.

Huang Y, Myers SJ, Dingledine R. Transcriptional repression by REST: Recruitment of Sin3A and histone deacetylase to neuronal genes. Nat Neurosci 1999;2(10):867-72.

Ballas N, Mandel G. The many faces of REST oversee epigenetic programming of neuronal genes. Curr Opin Neurobiol 2005;15(5):500-6.