CHEMICAL COMPOSITION OF ESSENTIAL OILS AND ITS LOCOMOTOR ACTIVIT FROM THE BARKS OF Cinnamomum sintok Bl OF TWO DISTRICTS IN MIDDLE JAVA

Muchtaridi Muchtaridi; Sri Sumiw; Rina F Nuwarda

doi:10.22159/ajpcr.2017.v10i4.15780

Authors

Muchtaridi Muchtaridi Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran http://orcid.org/0000-0002-6156-8025
Sri Sumiw
Rina F Nuwarda

DOI:

https://doi.org/10.22159/ajpcr.2017.v10i4.15780

Abstract

Objective: The objective of this study was to determine of volatile compounds of essential oils from Cinnamomum sintoc B1 (sintok) barks belongs to Lauraceae of two Districts of Middle Java.

Methods: Analysis of essential oil components from the barks of Cinnamomum sintoc Bl was performed by confirmation of the linear retention index (LRI), following byÂ the comparison of Â NIST library peak and mass spectrum peak with literature data.

Results: The essential oils from Yogyakarta andÂ Jember of Cinnamomum sintoc Bl obtained by steam distillation with percentage of Â 1.10% and 1.15% (w/w), respectively, with eugenol and methyl eugenol having higher percentage compare to other components, 35-38% and less than 10%, respectively. The sintok barks oil of Yogyakarta at 0.1 mL a dose decreased the locomotor activity as much as 11.33 %, while at 0.3 and 0.5 mL doses increased the locomotor activity as much as 35.83 % and 51.13 %.

Conclusion: It can be concluded from this study that the inhalation of sintok barks oil gave different influence to locomotor activity depends on the doses given.

Keywords: Cinnamomum sintoc Bl, methyl eugeunol, LRI, and eugenol

Â

Downloads

Download data is not yet available.

References

Muchtaridi M; Diantini A; Subarnas A, Analysis of Indonesian spice essential oil compounds that inhibit locomotor activity in mice. Pharmaceuticals 2011; 4, 590-602.

Kovar KA; Gropper B; Friess D; Ammon HP, Blood levels of 1,8-cineole and locomotor activity of mice after inhalation and oral administration of rosemary oil. Planta Med 1987; 53, 315-8.

Buchbauer G; Jirovetz L; Jager W; Dietrich H; Plank C, Aromatherapy: evidence for sedative effects of the essential oil of lavender after inhalation. Z Naturforsch C 1991; 46, 1067-72.

Muchtaridi M; Tjiraresmi A; Febriyanti R, Analysis of Active Compounds In Blood Plasma of Mice After Inhalation of Cajuput Essential Oil (Melaleuca leucadendron L.). Indonesian J. Pharm. 2015; 26.

Wiart C, Ethnopharmacology of Medicinal Plants Asia and The Pacific. humana Press: Totowa, New Jersey, 2006.

Jantan Ib; Yalvema MF; Ayop N; Ahmad AS, Constituents of the essential oils of Cinnamomum sintoc Blume from a mountain forest of Peninsular Malaysia. Flav. and Frag. 2005; 20, 601-604.

Sumiwi SA; Subarnas A; Supriyatna S; Abdasah M; Muchtaridi M, Analysis of chemical composition and its analgesic and anti-inflammatory activity of essential oil of sintoc bark (Cinnamomum sintoc bl.) using in vivo methods. Journal of Applied Pharmaceutical Science Vol 2015; 5, 058-065.

Jantan I; Rafi IA; Jalil J, Platelet-activating factor (PAF) receptor-binding antagonist activity of Malaysian medicinal plants. Phytomedicine 2005; 12, 88-92.

Muchtaridi M; Musfiroh I, Off-Line SPE-GC/MS Analysis of Lead Compounds Aromatherapy in Blood Plasma of Mice of Essential Oils Materials from Indonesian Aromatic Plants. Asian J. Chem 2012; 24, 5124.

Strehmel N; Hummel J; Erban A; Strassburg K; Kopka J, Retention index thresholds for compound matching in GC-MS metabolite profiling. J Chromatogr B Analyt Technol Biomed Life Sci 2008; 871, 182-90.

Ausloos P; Clifton CL; Lias SG; Mikaya AI; Stein SE; Tchekhovskoi DV; Sparkman OD; Zaikin V; Zhu D, The critical evaluation of a comprehensive mass spectral library. J Am Soc Mass Spectrom 1999; 10, 287-99.

Babushok VI; Linstrom PJ; Reed JJ; Zenkevich IG; Brown RL; Mallard WG; Stein SE, Development of a database of gas chromatographic retention properties of organic compounds. J Chromatogr A 2007; 1157, 414-21.

Adams RP, Identification of Essential Oil Components by Gas Chromatography/Mass Spectroscopy. Allured Publishing Corporation: Illinois, 1995.

Mijin DZ; Petrovic SD; Antonovic DG, Gas Chromatography Retention Indices of 2-Phenyl- 2 Alkylacetonitriles on Packed Coloumns. The Sci. J. Fact. Univ. 1999; 2, 1-8.

Muchtaridi M; Musfiroh I; Subarnas A; Rambia I; Suganda H; Nasrudin ME, Chemical composition and locomotors activity of essential oils from the rhizome, Stem, and leaf of Alpinia malaccencis (Burm F.) of Indonesian Spices. J. Appl. Pharmac.Sci. 2014; 4, 52.

Metcalf RL; Mitchell WC; Fukuto TR; Metcalf ER, Attraction of the oriental fruit fly, Dacus dorsalis, to methyl eugenol and related olfactory stimulants. Proc Natl Acad Sci U S A 1975; 72, 2501-5.

Dal Bo W; Luiz AP; Martins DF; Mazzardo-Martins L; Santos AR, Eugenol reduces acute pain in mice by modulating the glutamatergic and tumor necrosis factor alpha (TNF-alpha) pathways. Fundam Clin Pharmacol 2013; 27, 517-25.

Koh T; Murakami Y; Tanaka S; Machino M; Sakagami H, Re-evaluation of anti-inflammatory potential of eugenol in IL-1beta-stimulated gingival fibroblast and pulp cells. In Vivo 2013; 27, 269-73.

Tan KH; Nishida R, Methyl eugenol: its occurrence, distribution, and role in nature, especially in relation to insect behavior and pollination. J Insect Sci 2012; 12, 56.

Vargas RI; Shelly TE; Leblanc L; Pinero JC, Recent advances in methyl eugenol and cue-lure technologies for fruit fly detection, monitoring, and control in Hawaii. Vitam Horm 2010; 83, 575-95.

Zitzelsberger C; Buchbauer G, Essential Oils as "A Cry for Help". A Review. Nat Prod Commun 2015; 10, 1127-38.

Buchbauer G; Jager W; Jirovetz L; Meyer F; Dietrich H, Effects of valerian root oil, borneol, isoborneol, bornyl acetate and isobornyl acetate on the motility of laboratory animals (mice) after inhalation. Pharmazie 1992; 47, 620-2.