MEFENAMIC ACID-NICOTINAMIDE CO-CRYSTAL SYNTHESIZED BY USING MELT  CRYSTALLIZATION METHOD AND ITS SOLUBILITY STUDY

Dwi Utami; Ilma Nugrahani; Slamet Ibrahim

doi:10.22159/ajpcr.2017.v10i5.15863

Authors

Dwi Utami Ahmad Dahlan University, Yogyakarta, Indonesia
Ilma Nugrahani School of Pharmacy, Institute Technology Bandung
Slamet Ibrahim School of Pharmacy, Institute Technology Bandung

DOI:

https://doi.org/10.22159/ajpcr.2017.v10i5.15863

Keywords:

Co-crystal, Mefenamic acid, Nicotinamide, Melt crystallization, Solubility

Abstract

Objective: The focus of this study is to develop the formation mefenamic acid (MFA) - nicotinamide (NCT) co-crystal by using melt crystallization method and investigate its solubility.

Methods: Co-crystal was prepared by using melt crystallization method of MFA-NCT (1:2) at (220Â±3Â°C). The initial co-crystal formation wasÂ performed by powder X-ray diffraction (PXRD). The thin-layer chromatography (TLC) method was done to confirm the chemical stability of MFA and NCT due to synthesized process. The melt crystallization of MFA-NCT (1:2) was characterized by differential scanning calorimetry (DSC)/thermal gravimetric, infrared spectrophotometry, and scanning electron microscopy. The solubility of the melt crystallization of MFA-NCT (1:2) was evaluatedÂ by incubating the samples in water at 25Â°C and shaken for 24 hrs. The solubility of MFA was measured by ultraviolet-visible spectrophotometer.

Result: Characterization of a co-crystal MFA-NCT (1:2) including PXRD, Fourier transform infrared, DSC, and SEM have indicated the formation of new solid crystal phase that differs from MFA, NCT, and its physical mixture. The chromatogram of the TLC study exhibited two spot that corresponds to MFA and NCT. The solubility of the melt crystallization of MFA-NCT (1:2) was 57.97% higher than MFA solubility.

Conclusion: These results suggest that MFA-NCT co-crystal can be synthesized by using melt crystallization method without decomposition of its component and provides an opportunity for the development of MFA solid form.

Co-crystal, Mefenamic acid, Nicotinamide, Melt crystallization, Solubility.

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