PATTERN OF ADVERSE DRUG REACTIONS IN A TERTIARY CARE TEACHING HOSPITAL: A CROSS-SECTIONAL STUDY
DOI:
https://doi.org/10.22159/ajpcr.2017.v10i3.15972Abstract
ABSTRACT
Objective: The aim of this study was to carry out adverse drug reactions (ADRs) monitoring in various departments of a tertiary care teaching hospital.
Methods: A cross-sectional study was conducted on ADRs reported in the hospital from December 2012 to May 2013 after obtaining Institutional
Ethics Committee approval.
Results: A total of 40 ADRs were reported, 47.50% were males and 52.50% were females. The female adult population was 45%. The majority of ADRs
were due to antimicrobial agents especially beta-lactam antibiotics (42.5%) followed by NSAIDs (7.50%). A maximum number of patients (75%)
were reported with dermatological manifestations. The department of medicine reported the highest number of ADRs (37.5%). As per Naranjo's
probability scale, 62.5% reports were assessed as probable. 62.5% reports were documented as mild according to Modified Hartwig's criteria for
severity assessment.
Conclusion: This study was done to sensitize the practicing physicians on the importance of adverse drug monitoring and reporting.
Keywords: Pharmacovigilance, Adverse drug reactions, Tertiary care teaching hospital, Antimicrobial agents.
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Table 1: Types of reactions for drugs in reported ADRs
Reactions
Drugs
Number of ADRs (%)
Urticaria
Ceftriaxone with sulbactam, Ceftriaxone, Ceftriaxone with tazobactam, Cefotaxime, Phenytoin, Ciprofloxacin, Cotrimoxazole, Metronidazole
(62.5)
Erythematous skin lesion
Diclofenac sodium, Cotrimoxazole, Paracetamol, Phenytoin, Carbamezapine, Clindamycin
(18.75)
Chest tightness and pain
Metronidazole, Iopamide
(6.25)
Throat irritation
Ciprofloxacin
(3)
Facial edema
Cefotaxime
(3)
Rigor
Vancomycin
(3)
Lip edema
Cotrimoxazole
(3)
ADRs: Adverse drug reactions
Table 2: List of organs system in ADRs
Organ system
Number of ADRs (%)
Skin
Gastrointestinal system
Cardiovascular system
‑
Central nervous system
‑
Respiratory
Genitourinary
Eyes, ears, nose and throat
‑
ADRs: Adverse drug reactions
Asian J Pharm Clin Res, Vol 10, Issue 3, 2017, 170-173
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