FORMULATION AND EVALUATION OF SYNTHESIZED QUINAZOLINONE DERIVATIVE FOR COLON SPECIFIC DRUG DELIVERY
DOI:
https://doi.org/10.22159/ajpcr.2017.v10i3.16024Abstract
ABSTRACT
Objective: The current research deals with the formulation and evaluation of synthesized quinazolinone derivative for colon site specific delivery.
Methods: The synthesized quinazolinone derivative was enteric coated 5% Eudragit L-100 with by wet granulation method using guar gum, pectin,
and guar gum pectin combination as hydrophilic polymer. The prepared matrix tablet was characterized by differential scanning calorimetry and
evaluated for different pre-compression and post-compression studies and drug release profiles.
Results: All the matrix tablets were within the range of pharmacopeial limits with better flow properties. All the six formulations of matrix tablets had
disintegrated within 5-6 minutes. The optimized formulation selected was F6 formulation combination of guar gum and pectin with 95.79% of drug
release than compared to the remaining formulation. The optimized matrix tablets followed zero order kinetics with Fickian diffusion.
Conclusion: The results proposed that the combination of guar gum and pectin coated tablet with 5% Eudragit L-100 of synthesized quinazolinone
derivative is a promising colon site specific delivery.
Keywords: Quinazolinone derivative, In vitro drug release, Disintegration time, Guar gum, Pectin, 5% Eudragit L-100, Colon site-specific delivery, Wet
granulation, Compression.
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