ANTI-INFLAMMATORY EFFECT OF ZINGIBER OFFICINALE ON SPRAGUE DAWLEY RATS

Ndanusa Abdullahi Hassan; Rohini Karunakaran; Uma Sankar A; Khin Mar Aye

doi:10.22159/ajpcr.2017.v10i3.16251

Authors

Ndanusa Abdullahi Hassan
Rohini Karunakaran Faculty of Medicine AIMST University
Uma Sankar A
Khin Mar Aye

DOI:

https://doi.org/10.22159/ajpcr.2017.v10i3.16251

Abstract

ABSTRACT
Objective: To investigate the anti-inflammatory effect of aqueous extract of Zingiber officinale on carrageenan-induced inflammation on Sprague
Dawley (SD) rats.
Methods: SD rats were divided into six of five groups and allowed to acclimatize for 1 week. Inflammation was induced on the animal by injecting the
right hand paw with carrageenan (0.1 ml of 1%). Group 1 was given normal saline and served as a control. Group 2 was fed with food and water and
served as the carrageenan control. Group 3 was given 200 mg/kg aqueous extract of ginger, Group 4 with 400 mg/kg aqueous extract of ginger, and
Group 5 with 150 mg/kg diclofenac sodium (reference drug for inflammation).
Results: The paw edema in carrageenan-induced SD rats was considerably reduced by treating with 400 mg/kg aqueous ginger extracts when
compared to the untreated SD rats (p<0.001).
Conclusion: This study indicates that aqueous extract of Z. officinale possesses anti-inflammatory properties.
Keywords: Anti-inflammatory, Sprague Dawley rats, Zingiber officinale, Carrageenan, Edema

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Author Biography

Rohini Karunakaran, Faculty of Medicine AIMST University

Associate Professor & Preclinical Coordinator

Faculty of Medicine

AIMST University

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