EVALUATION OF NEPHROPROTECTIVE ACTIVITY OF MENTHA ARVENSIS IN CISPLATIN INDUCED NEPHROTOXICITY
Abstract
Present study was performed to evaluate the effect of Mentha arvensis on cisplatin-induced nephrotoxicity in Sprague-Dawley rats. The M. arvensis
hydroalcoholic extract (MAHE) was administered orally at two dose levels (200 mg/kg and 400 mg/kg). The kidney function test (estimation of serum
creatinine, total protein, blood urea nitrogen [BUN], and urea), oxidative stress study (estimation of superoxide dismutase [SOD] activity, glutathione
content, and lipid peroxides [LPO]), and histological studies were also conducted. MAHE was found effective at both doses, although high dose
(400 mg/kg) was found more effective, which was evidenced by decrease in serum creatinine, total protein, BUN, urea, and LPO and increased in SOD
activity. Histopathological studies were also confirmed the nephroprotective action of MAHE. Present investigation revealed that M. arvensis showed
nephroprotective effect on cisplatin nephrotoxicity in Sprague-Dawley rats which may be due to the presence of flavonoids and related compounds.
Keywords: Mentha arvensis, Pudina, Nephroprotective activity, Nephrotoxicity.
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