A RANDOMIZED, OPEN LABEL, COMPARATIVE STUDY OF LYSINE CREAM WITH STANDARD TREATMENT IN PATIENTS WITH SECOND DEGREE SUPERFICIAL BURNS

Authors

  • Saravanan P Department of Pharmacology, Coimbatore Medical College, Coimbatore, Tamil Nadu, India.
  • Chenthamarai G Department of Pharmacology, Madras Medical College, Chennai, Tamil Nadu, India

DOI:

https://doi.org/10.22159/ajpcr.2017.v10i5.16431

Keywords:

Growth factor, Angiogenesis, Lysine, Body surface area

Abstract

Objective: To evaluate the efficacy and tolerability of lysine cream in patients with second-degree superficial burns.

Methods: In this randomized, open label, comparative study patients with second degree superficial burns received either combination of lysine cream 15% and silver sulfadiazine cream 1% or sulfadiazine cream 1% alone, twice daily for period of 4 weeks. The primary outcome, pain, discharge, size and total body surface area (TBSA) were assessed in each visits.

Results: Patients in the study group showed significant change than the control group in pain, discharge, size, and TBSA during the first 4 weeks after treatment. In addition, significantly more patients in lysine group had adequate relief of itching and increased epithelialization.

Conclusions: Combination of lysine cream and silver sulfadiazine cream for 4 weeks provided significant relief of pain, discharge, size, TBSA, and itching. Lysine cream was well tolerated.

 

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Author Biography

Saravanan P, Department of Pharmacology, Coimbatore Medical College, Coimbatore, Tamil Nadu, India.

Dr.P.saravanan M.D., Assistant professor in Pharmacology, Coimbatore Medical College, Coimbatore, Tamilnadu.

References

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R.K. Gupta, A. Agarwal, S. Agarwal, Reversal Of Acute Human Brain Ischemic Injury By Lysine Induced Therapeutic Angiogenesis: Preliminary Results Of A Pilot Study. The Internet Journal of Neurology. 2005 Volume 4 Number 1

Alain Siméon, Yanusz Wegrowski, Yannick Bontemps Expression of Glycosaminoglycans and Small Proteoglycans in Wounds: Modulation by the Tripeptide – Copper Complex Glycyl-L-Histidyl-L-Lysine-Cu2+, Faculté de Médecine, Reims, France. Journal of Investigative Dermatology (2000) 115, 962–968; doi:10.1046/j.1523-1747. 2000. 00166.

Published

01-05-2017

How to Cite

P, S., and C. G. “A RANDOMIZED, OPEN LABEL, COMPARATIVE STUDY OF LYSINE CREAM WITH STANDARD TREATMENT IN PATIENTS WITH SECOND DEGREE SUPERFICIAL BURNS”. Asian Journal of Pharmaceutical and Clinical Research, vol. 10, no. 5, May 2017, pp. 219-21, doi:10.22159/ajpcr.2017.v10i5.16431.

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Section

Original Article(s)