UV SPECTROPHOTOMETRIC METHOD DEVELOPMENT AND VALIDATION FOR TELMISARTAN IN BULK AND TABLET DOSAGE FORM
Abstract
Objective: To develop UV spectrophotometric method for determination of Telmisartan in bulk and tablet dosage form in 0.1 N NaOH by two methods. Methods: Method A involve Absorption maxima method based on the measurement of absorbance at 295 nm that is the λmax of Telmisartan, while Method B involved Area under the curve based on the measurement of AUC in the range of 275-310 nm. Results: Both methods obey Beer- Lamberts law in concentration range of 2-12 µg/ml. Methods were validated as per ICH guidelines in terms of accuracy, linearity and precision. Conclusion: The proposed methods found to be simple, accurate, precise, reproducible, economic and suitable for routine quality control analysis.
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