DESIGN AND EVALUATION OF INTRAGASTRIC BUOYANT TABLETS OF VENLAFAXINE HYDROCHLORIDE

RADHIKA PR; Nishala N; Kiruthika M; Sree Iswarya S

doi:10.22159/ajpcr.2017.v10i5.16948

Authors

RADHIKA PR J.K.K.NATTARAJA COLLEGE OF PHARMACY, KOMARAPALAYAM, NAMAKKAL DISTRICT
Nishala N J.K.K.NATTARAJA COLLEGE OF PHARMACY, KOMARAPALAYAM, NAMAKKAL DISTRICT
Kiruthika M J.K.K.NATTARAJA COLLEGE OF PHARMACY, KOMARAPALAYAM, NAMAKKAL DISTRICT
Sree Iswarya S J.K.K.NATTARAJA COLLEGE OF PHARMACY, KOMARAPALAYAM, NAMAKKAL DISTRICT

DOI:

https://doi.org/10.22159/ajpcr.2017.v10i5.16948

Keywords:

Venlafaxine hydrochloride, Intragastric buoyant, Floating drug delivery systems, Hydroxypropyl methyl cellulose K100M, Carbopol 934 P, Xanthan gum

Abstract

Objective: The present study was undertaken to prolong the release of orally administered drug. The aim is to formulate, develop, and evaluate the
intragastric buoyant tablets of venlafaxine hydrochloride, which releases the drug in a sustained manner over a period of 12 hrs. Different formulations
were formulated using the polymers Carbopol 934 P, xanthan gum, hydroxypropyl methylcellulose (HPMC K100M) with varying concentration of
drug: Polymer ratio of 1:1, 1:1.5, 1:2, in which sodium bicarbonate acts as gas generating agent, and microcrystalline cellulose as a diluent.

Methods: The tablets were prepared by direct compression and evaluated for tablet thickness, weight variation, tablet hardness, friability, in vitro
buoyancy test, in vitro drug release and Fourier transform infrared spectroscopy. Formulations were evaluated by floating time, floating lag time and in vitro drug release. Dissolution profiles were subjected for various kinetic treatments to analyze the release pattern of drug.
Results: It was found that drug release depends on swelling, erosion, and diffusion, thus following the non-Fickian/anomalous type of diffusion.
Formulation F8 was considered as an optimized formulation for gastro retentive floating tablet of venlafaxine hydrochloride. The optimized
formulation showed sustained drug release and remained buoyant on the surface of the medium for more than 12 hrs. As the concentration of HPMC
K100M increases in the formulation the drug release rate was found to be decreased. The optimized formulation was subjected for the stability studies
and was found to be stable as no significant change was observed in various evaluated parameters of the formulation.
Conclusion: It can be concluded that floating drug delivery system of venlafaxine hydrochloride can be successfully formulated as an approach to
increase gastric residence time, thereby improving its bioavailability.
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Author Biography

RADHIKA PR, J.K.K.NATTARAJA COLLEGE OF PHARMACY, KOMARAPALAYAM, NAMAKKAL DISTRICT

DEPARTMENT OF PHARMACEUTICS,

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