ASSOCIATION OF SERUM URIC ACID AND LIPID PROFILE IN TYPE 2 DIABETIC PATIENTS WITH AND WITHOUT DIABETIC RETINOPATHY
DOI:
https://doi.org/10.22159/ajpcr.2017.v10i6.17029Keywords:
Serum uric acid, Diabetic retinopathy, Lipid profile, Type 2 diabetesAbstract
Objectives: Diabetic retinopathy (DR) is one of the microvascular complications in type 2 diabetes (T2D). Â Elevated serum uric acid (SUA) has been shown to play a significant role in diabetic neuropathy and nephropathy but there is little information on retinopathy. Therefore, the present study was aimed to investigate the SUA and lipid profile in T2D patients with and without DR and the association between SUA and severity of DR.
Methods: The study was conducted in the ophthalmology OPD at Sri Lakshmi Narayana Institute of Medical Sciences. The presence of T2D was confirmed by investigating fasting blood glucose level (normal limit < 110 mg/dl) in all the individuals. DR was examined by detailed dilated fundoscopic examination. Based on the fundus examination, patients were divided in to diabetes with signs of DR and those without signs of DR. Age and sex matched healthy were taken as controls. Fasting blood sugar, SUA and lipid profile were investigated for these groups.
 Results: The study found elevated SUA and abnormal lipid profile in DR group when compared to non-DR and control groups. We also found the significant association between SUA and severity of DR particularly in males.
Conclusion: We found a significant association between SUA and severity of DR in T2D patients. Further studies with large sample size are needed to establish the role of elevated SUA and the mechanism involved in the pathogenesis of retinopathy in diabetic patients. Regular measurements of SUA level could be advised to the diabetic patients for the early management.
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References
Eman MA. FTIR analysis for retina associated with diabetic changes and treatment with oat. Int J Pharm Pharm Sci 2015;7:277-80.
Fong DS, Aiello LP, Ferris FL 3rd, Klein, R. Diabetic retinopathy. Diabetes Care 2004;27:2540-53.
Sivaprasad S, Gupta B, Crosby-Nwaobi R, Evans J. Prevalence of diabetic retinopathy in various ethnic groups: A worldwide perspective. Surv Ophthalmol 2012;57:347-70.
Kiani J, Habibi Z, Tajziehchi A, Moghimbeigi A, Dehghan A, Azizkhani H. Association between serum uric acid level and diabetic peripheral neuropathy (A case control study). Caspian J Intern Med 2014;5(1):17-21.
Wu L, Fernandez-Loaiza P, Sauma J, Hernandez-Bogantes E, Masis M. Classification of diabetic retinopathy and diabetic macular edema. World J Diabetes 2013;4:290-4.
Liang CC, Lin PC, Lee MY, Chen SC, Shin SJ, Hsiao PJ, Lin KD, et al. Association of serum uric acid concentration with diabetic retinopathy and albuminuria in Taiwanese patients with Type 2 diabetes mellitus. Int J Mol Sci 2016;7(8):1248.
Lee JJ, Yang IH, Kuo HK, Chung MS, Chen YJ, Chen CH, et al. Serum uric acid concentration is associated with worsening in severity of diabetic retinopathy among Type 2 diabetic patients in Taiwan-A 3-year prospective study. Diabetes Res Clin Pract 2014;106:366-72.
Fukui M, Tanaka M, Shiraishi E, Harusato I, Hosoda H, Asano M, et al. Serum uric acid is associated with microalbuminuria and subclinical atherosclerosis in men with Type 2 diabetes mellitus. Metabolism 2008;57:625-9.
Herman JB, Medalie JH, Goldbourd U. Diabetes, prediabetes and uricemia. Diabetologia 1976;12:47-52.
Tuomilehto J, Zimmet P, Wolf E, Taylor R, Ram P, King H. Plasma uric acid level and its association with diabetes mellitus and some biologic parameters in a biracial population of Fiji. Am J Epidemiol 1988;127:321-36.
Kodama S, Sugawara A, Saito K, Yachi Y, Asumi M, Totsuka K, et al. Association between serum uric acid and development of Type 2 diabetes. Diabetes Care 2009;32:1737-42.
Galvan QA, Natali A, Baldi S, Frascerra S, Sanna G, Ciociaro D. Effect of insulin on uric acid excretion in humans. Am J Physiol 1995;268:E1-5.
Navin S, Krishnamurthy N, Ashakiran S, Dayanand CD. The association of hypomagnesaemia, high normal uricaemia and dyslipidaemia in the patients with diabetic retinopathy. J Clin Diagn Res 2013;7:1852-4.
Cai XL, Wang F, Ji LN. Risk factors of diabetic retinopathy in Type 2 diabetic patients. Chin Med J 2006;119:822-6.
Krizova L, Kalousova M, Kubena A, Benakova H, Zima T, Kovarik Z, et al. Increased uric acid and glucose concentrations in vitreous and serum of patients with diabetic macular oedema. Ophthalmic Res 2011;46:73-79.
Krizova L, Kalousova M, Kubena AA, Chrapek O, Chrapkova B, Sin M, et al. Correlation of vitreous vascular endothelial growth factor and uric acid concentration using optical coherence tomography in diabetic macular edema. J Ophthalmol 2015;2015:7.
Bhaktha G, Shantaram M, Nayak S. Beneficial effects of coffee and maintenance of uric acid levels. Int J Pharm Pharm Sci 2016;8:393-5.
Aiello LP, Avery RL, Arrigg PG, Keyt BA, Jampel HD, Shah ST, et al. Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders. N Engl J Med 1994:331(22):1480-7.
Selim KM, Sahan D, Muhittin T, Osman C, Mustafa O. Increased levels of vascular endothelial growth factor in the aqueous humor of patients with diabetic retinopathy. Indian J Ophthalmol 2010;58:375-9.
Funatsu H, Yamashita H, Noma H, Mimura T, Nakamura S, Sakata K, et al. Aqueous humor levels of cytokines are related to vitreous levels and progression of diabetic retinopathy in diabetic patients. Graefes Arch Clin Exp 2005;243(1):3-8.
Idiculla J, Nithyanandam S, Joseph M, Mohan VK, Vasu U, Sadiq M. Serum lipids and diabetic retinopathy: A cross-sectional study. Indian J Endocrinol Metab 2012;16:S492-4.
Agroiya P, Philip R, Saran S, Gutch M, Tyagi R, Gupta KK. Association of serum lipids with diabetic retinopathy in Type 2 diabetes. Int J Ophthalmol 2013;17:335-7.
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