• Diksha Sharma Department of Pharmacy, L. R. Institute of Pharmacy, Solan, Himachal Pradesh, India
  • Abhishek Sharma Department of Pharmacy, L. R. Institute of Pharmacy, Solan, Himachal Pradesh, India



Magnetic microspheres, Targeted drug delivery, target sites, Body, Radiation, Efficiency, Toxicity, Reduce side effec



 The drug delivery system has been advanced to release the drug according to the body requirement during the entire period of treatment and also for the delivery at the targeted site. Several novel drug delivery systems have emerged encompassing different route of administration to achieve controlled and targeted drug delivery, magnetic microsphere carrier being one of them. Magnetic microsphere is an alternative to traditional radiation methods. As the traditional radiation methods use highly penetrating radiation that is absorbed throughout the body and cause side effects hence its use is limited. Therefore, a safe and effective alternate is needed like magnetic microsphere. The excessive circulating drug particles are minimized by this delivery system. Moreover, the aim of specific targeting is to enhance the effectiveness of drug delivery and at the same time to lessen the toxicity and side effects. Magnetic carriers receive magnetic responses to a magnetic field from incorporated materials that are used for magnetic microsphere are chitosan, dextran, etc. One of the most utilized magnetic microspheres is serum albumine whether from human or other suitable animals. Drug release from the albumin microsphere can be controlled by various stabilization procedures. Overall, the targeted magnetic microsphere is much valuable novel drug delivery system for what more work have to be done. By knowing the importance of all this, the present paper reviews the mechanism, preparation, and applications of magnetic microspheres. As the targeted drug delivery system implies selective and effective localization of drug into the target at therapeutic concentrations with limited access to non-target sites. Magnetic microspheres hold great promises for reaching the goal of controlled and site-specific drug delivery.


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Peppas NA, Hilt JZ, Khademhosseini A, Langer R. Hydrogels in biology and medicine: From molecular principles to bio-nanotechnology. Adv Mater 2006;18:1345-60.

Huang X, Brazel CS. On the importance and mechanisms of burst release in matrix-controlled drug delivery systems. J Control Release 2001;73(2-3):121-36.

Bhattarai N, Gunn J, Zhang M. Chitosan-based hydrogels for controlled, localized drug delivery. Adv Drug Deliv Rev 2010;62(1):83-99.

Kim KK, Pack DW. Microspheres for drug delivery. Biol Biomed Technol 2006;1:19-20.

Bergemann C, Muller-Schulte D, Oster J, Brassard L, Lubbe AS. Magnetic ion-exchange nano - And microparticles for medical, biochemical and molecular biological applications. J Magn Magn Mater 1999;194:45-52.

Asmatulu R, Zalich MA, Claus RO. Synthesis, characterization and targeting of biodegradable magnetic nanocomposite particles by external magnetic fields. J Magn Magn Mater 2005;292:108-19.

Vyas SP, Khar RK. Targeted and Controlled Drug Delivery. New Delhi: CBC Publisher & Distributors; 2004. p. 459-63.

Johansen L, Nustad K, Ørstavik TB, Ugelstad J, Berge A, Ellingsen T. Excess antibody immunoassay for rat glan-dular kallikrein. Mono-sized polymer particles as the prefered solid phase material. J Immunol Methods 1983;59:255-64.

Lang C, Schuler D. Biogenic nanoparticles: Production, characterization, and application of bacterial magnetosomes. J Phys Condens Matter 2006;18:S2815-28.

Weckler B, Lutz HD. Magnetic microsphere an emerging drug delivery system. Solid State Inorg Chem Eur J Mol Struct 1998;35:531-44.

Gallo JM, Gupta PK, Hung CT, Prrier DG. Evaluation of drug delivery following the administration of magnetic albumin microspheres containin adriamycin to the rat. J Pharm Sci 1989;78:190-4.

Available from: pdf accessed on 25/02/2011.

Lachman LA, Liberman HA, Kanig JL. The Theory and Practice of Industrial Pharmacy. Mumbai, India: Varghese Publishing House; 2002. p. 414-5.

Salim MD, Shukla VK, Bhardwaj V, Garg VK, Sharma PK. Magnetic microspheres as a magnetically targeted drug delivery system. J Glob Pharm Technol 2010;2(3):36-46.

Collins AE, Deasy PB. Bioadhesive lozenge for the improved delivery of cetylpyridinium chloride. J Pharm Sci 1990;79(2):116-9.

Wang KE, Xing JF, Li XY, Fu Q, Li WF. Fabrication of novel magnetic nanoparticles-coated P(styrene-itaconic acid-divinylbenzene) microspheres. Carbohydr Polym 2009;321:1951-4.

Nasra MK, Mohamed MM, Elblbesy MA, Hefney BA. Preparation of biocompatible magnetic microspheres with Chitosan. J Biomater Nanobiotechnol 2011;2:194-200.

Chung TH, Lee WC. Preparation of styrene-based, magnetic polymer microspheres by a swelling and penetration process. React Funct Polym 2008;68:1441-7.

Keller MW, Feinstein SB. In: Kerber RE, editor. Echocardiography in Coronary Artery Disease. New York: Churchill Livingstone; 1988. p. 443-65.

Suslick KS. The chemistry of ultrasound, encyclopaedia britannica yearbook of science and the future. Britannica. Chicago: Encyclopædia Britannica, Inc.; 1994. p. 138-55.

Cax X, Prozorov R, Koltypin Y, Kataby G, Felner I, Gedanken A. Annealing study of Fe2O3 nanoparticles: Magnetic size effects and phase transformations. J Mater Chem 1997;12:402-7.

Cax X, Koltypin Y, Prozorov R, Felner I, Gedanken A. Preparation and characterization of amorphous nanometer sized Fe3O4 powder. J Mater Chem 1997;7:1007-9.

Yeung YA, Wittrup KD. Quantitative screening of yeast surface-displayed polypeptide libraries by magnetic bead capture. Biotechnol Prog 2002;18(2):212-20.

Le B, Shinkai M, Kitade T, Honda H, Yoshida J, Wakabayashi T. Medical applications of functionalized magnetic nanoparticles. J Chem Eng Jpn 2001;34:66-72.

Chan LW, Heng PW. Effects of poly (vinylpyrrolidone) and ethylcellulose on alginate microspheres prepared by emulsification. J Microencapsul 1998;15(4):409-20.

Nachts S, Martin K. The Microsponges: A Novel Topical Programmable Delivery Formulation. New York: Marcel Dekker Inc.; 1990. p. 299.

Lea T, Vartdal F, Davies C, Ugelstad J. Magnetic monosized polymer particles for fast and specific fractionation of human mononuclear cells. Scand J Immunol 1985;22(2):207-16.



How to Cite

Sharma, D., and A. Sharma. “MAGNETIC MICROSPHERE AN EMERGING DRUG DELIVERY SYSTEM”. Asian Journal of Pharmaceutical and Clinical Research, vol. 10, no. 6, June 2017, pp. 54-58, doi:10.22159/ajpcr.2017.v10i6.17284.



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