ORAL CAVITY SQUAMOUS CELL CARCINOMA IN A CASE OF IFAP SYNDROME WITH CHRONIC MYELOID LEUKEMIA ON LONG TERM HYDROXYUREA: A RARE PRESENTATION

Authors

  • Uday Kumar P MNJ INSTITUTE OF ONCOLOGY, REGIONAL CANCER CENTRE , HYDERABAD, TELANGANA 500004
  • Anshul Singh MANIPAL UNIVERSITY
  • Anusha Reddy s MANIPAL UNIVERSITY
  • VIDYASGAR MS MANIPAL UNIVERSITY
  • Prahlad Hy MANIPAL UNIVERSITY

DOI:

https://doi.org/10.22159/ajpcr.2017.v10i5.17665

Keywords:

Hydroxyurea, Ichthyosis follicularis, alopecia, and photophobia, Myeloid leukemia

Abstract

We report a case of  a patient  in his early  30s' who presented with an ulcero-proliferative growth over the left buccal mucosa , he was also on treatment for CML in blast crisis on Hydroxyurea and a known case of Ichthyosis Follicularis, Alopecia, and Photophobia (IFAP) syndrome. Though a working diagnosis of chloroma / Hydroxyurea induced erosive Lichen planus  was suspected, the histopathological examination of the lesion was suggestive of Squamous cell Carcinoma. He was subsequently planned for palliative radiotherapy .

 

Downloads

Download data is not yet available.

Author Biographies

Uday Kumar P, MNJ INSTITUTE OF ONCOLOGY, REGIONAL CANCER CENTRE , HYDERABAD, TELANGANA 500004

DEPARTMENT OF RADIOTHERAPY
SENIOR RESIDENT

Anshul Singh, MANIPAL UNIVERSITY

DEPARTMENT OF RADIOTHERAPY AND ONCOLOGY
ASSISTANT PROFESSOR

Anusha Reddy s, MANIPAL UNIVERSITY

DEPARTMENT OF RADIOTHERAPY
SENIOR RESIDENT

VIDYASGAR MS, MANIPAL UNIVERSITY

DEPARTMENT OF RADIOTHERAPY
PROFESSOR

Prahlad Hy, MANIPAL UNIVERSITY

DEPARTMENT OF RADIOTHERAPY
ASSISTANT PROFESSOR

References

Mégarbané H, Mégarbané A. Ichthyosis follicularis, alopecia, and photophobia (IFAP) syndrome. Orphanet J Rare Dis 2011;6:29.

Keyvani K, Paulus W, Traupe H, Kiesewetter F, Cursiefen C, Huk W, et al. Ichthyosis follicularis, alopecia, and photophobia (IFAP)

syndrome: Clinical and neuropathological observations in a 33-yearold man. Am J Med Genet 1998;78(4):371-7.

Boente MC, Bonet HB, Coronel AM, Asial RA. Atrichia, ichthyosis follicular hyperkeratosis, chronic candidiasis, keratitis, seizures,

mental retardation and inguinal hernia: A severe manifestation of IFAP syndrome? Eur J Dermatol 2000;10:98-102.

Darji AA, Bharadia PD. Chronic myelogenous leukemia: A review and update of current and future therapy. Int J Pharm Pharm Sci 2016;8:35-46. Available from: http://www.innovareacademics.in/ journals/index.php/ijpps/article/view/12124.

Ting CY, Shamsuddin AF. Optimized RNA extraction for detection of BCR-ABL transcripts in chronic myeloid leukemia patients during treatment. Int J Pharm Pharm Sci 2014;6(1):415-8.

De Benedittis M, Petruzzi M, Giardina C, Lo Muzio L, Favia G, Serpico R. Oral squamous cell carcinoma during long-term treatment with hydroxyurea. Clin Exp Dermatol 2004;29(6):605-7.

Budrukkar A, Muttagi S, Shahid T, Chatturvedi P, Banavali S, Laskar SG, et al. Second primary head and neck squamous cell cancers

with aggressive behavior in patients with chronic myeloid leukaemia. Br J Oral Maxillofac Surg 2012;50(6):504-7.

Published

01-05-2017

How to Cite

P, U. K., A. Singh, A. Reddy s, VIDYASGAR MS, and Prahlad Hy. “ORAL CAVITY SQUAMOUS CELL CARCINOMA IN A CASE OF IFAP SYNDROME WITH CHRONIC MYELOID LEUKEMIA ON LONG TERM HYDROXYUREA: A RARE PRESENTATION”. Asian Journal of Pharmaceutical and Clinical Research, vol. 10, no. 5, May 2017, pp. 1-3, doi:10.22159/ajpcr.2017.v10i5.17665.

Issue

Section

Case Study(s)