ORAL CAVITY SQUAMOUS CELL CARCINOMA IN A CASE OF IFAP SYNDROME WITH CHRONIC MYELOID LEUKEMIA ON LONG TERM HYDROXYUREA: A RARE PRESENTATION
DOI:
https://doi.org/10.22159/ajpcr.2017.v10i5.17665Keywords:
Hydroxyurea, Ichthyosis follicularis, alopecia, and photophobia, Myeloid leukemiaAbstract
We report a case of a patient in his early 30s' who presented with an ulcero-proliferative growth over the left buccal mucosa , he was also on treatment for CML in blast crisis on Hydroxyurea and a known case of Ichthyosis Follicularis, Alopecia, and Photophobia (IFAP) syndrome. Though a working diagnosis of chloroma / Hydroxyurea induced erosive Lichen planus was suspected, the histopathological examination of the lesion was suggestive of Squamous cell Carcinoma. He was subsequently planned for palliative radiotherapy .
Â
Downloads
References
Mégarbané H, Mégarbané A. Ichthyosis follicularis, alopecia, and photophobia (IFAP) syndrome. Orphanet J Rare Dis 2011;6:29.
Keyvani K, Paulus W, Traupe H, Kiesewetter F, Cursiefen C, Huk W, et al. Ichthyosis follicularis, alopecia, and photophobia (IFAP)
syndrome: Clinical and neuropathological observations in a 33-yearold man. Am J Med Genet 1998;78(4):371-7.
Boente MC, Bonet HB, Coronel AM, Asial RA. Atrichia, ichthyosis follicular hyperkeratosis, chronic candidiasis, keratitis, seizures,
mental retardation and inguinal hernia: A severe manifestation of IFAP syndrome? Eur J Dermatol 2000;10:98-102.
Darji AA, Bharadia PD. Chronic myelogenous leukemia: A review and update of current and future therapy. Int J Pharm Pharm Sci 2016;8:35-46. Available from: http://www.innovareacademics.in/ journals/index.php/ijpps/article/view/12124.
Ting CY, Shamsuddin AF. Optimized RNA extraction for detection of BCR-ABL transcripts in chronic myeloid leukemia patients during treatment. Int J Pharm Pharm Sci 2014;6(1):415-8.
De Benedittis M, Petruzzi M, Giardina C, Lo Muzio L, Favia G, Serpico R. Oral squamous cell carcinoma during long-term treatment with hydroxyurea. Clin Exp Dermatol 2004;29(6):605-7.
Budrukkar A, Muttagi S, Shahid T, Chatturvedi P, Banavali S, Laskar SG, et al. Second primary head and neck squamous cell cancers
with aggressive behavior in patients with chronic myeloid leukaemia. Br J Oral Maxillofac Surg 2012;50(6):504-7.
Published
How to Cite
Issue
Section
The publication is licensed under CC By and is open access. Copyright is with author and allowed to retain publishing rights without restrictions.