ANTIBIOTIC UTILIZATION PATTERN AT THE SURGERY DEPARTMENT OF A TERTIARY CARE HOSPITAL
Keywords:Antibiotics, Surgery, Prescription Pattern
Objective: The present study aims to determine the pattern of antibiotic utilization at the surgery department of a tertiary care hospital.
Method: A prospective observational study was conducted over a period of 6 months period in surgical ward at Bharti Hospital and Research Centre, Pune, a 1000 bedded teaching hospital. Patients above 18 years and receiving antibiotic therapy pre and post-surgery were included in the study.
Results:160 patients with surgical operations were included in the study.The disease spectrum was classified into respective system-wise surgical procedures of which 49.37% cases are skin & soft tissue infections, 25.62% cases of general surgical procedure, 12.5% cases of gastrointestinal surgical procedure, 11.25% cases of urinary system and 1.25% case of head neck system. 20.62% of the study patients had hernia, 18.12% patients had cellulitis, 16.87% patients had diabetic foot ulcer, 16.25% patients had abscess, and 10.62% patients had appendicitis and cholelithiasis. In this study, it was found that 471 antibiotics were used in total of 160 patients, among which highest group of antibiotics prescribed were third generation Cephalosporin (28.23%) followed by Penicillins (23.56%). The most frequently prescribed antibiotics were Metronidazole âˆ’ 19.74% among the Nitroimidazoles followed by Ceftriaxone âˆ’ 19.53% of the class Cephalosporins.
Conclusion: The rate of prescribing of broad-spectrum antibiotics has increased demonstrably which may result in development of bacterial resistance; however development of guidelines for antibiotic prescription and use of appropriate drugs for the diseases can minimize the unfavourable use of antibiotics and cost of healthcare.
Centre for Disease Dynamics, Economics and Policy. State of the Worldâ€™s Antibiotics. Washington, DC: CDDEP; 2015.
Masiero G , Filippini M, Ferech M, Goossens H. Socioeconomic determinants of outpatient antibiotic use in Europe. Int J Public Health 2010; 55(5):469-78 .
Patherick ES, Dalton JE. Methods for identifying surgical wound infections after discharging from hospital: A systematic review. BMC Infect Dis 2006;6:170-8.
Scottish intercollegiate guidelines network 104, Antibiotic Prophylaxis in Surgery. A National Clinical Guideline. July; 2018 and updated April; 2014.
Abula T, Kedir M. The pattern of antibiotic usage in surgical in-patients of a teaching hospital, Northwest Ethiopia. Ethiop J Health Dev 2004;18(1):35-8.
George SS, Varghese SR, Samuel CJ. Evaluation of antibiotic prescribing patterns among medical practitioners in North India. Indian J Basic Appl Med Res 2013;8(2):952-7.
Kumar BA, Adiveni T, Chandra DS, Charan N, Padmini P, Ashwini K, et al. Study and use of antimicrobials in post-operative wound infections in gastrointestinal surgeries. Indo Am J Pharm Res 2013;3(4):1-5.
Babu KJ, Devarajan K, Paidi NR, Ramaswamy R, Sudarshan P. Study of antimicrobial prophylaxis pattern in surgical procedures and incidence of post-operative infection - A retrospective study. Indo Am J Pharm Res 2015;5(3):1-9.
Chowdhury MK, Siddique AA, Sarkar PK, Haque M. Pattern of antibiotic use in different departments of Dhaka medical college hospital. J Med 2015;16(1):35-8.
Pandiamunian J, Somasundaram G. A study on prescribing pattern of anti microbial agents in the medical intensive care unit of a tertiary care teaching hospital in Puducherry Union Territory, South India. Int J Pharm Pharm Sci 2014;6(3):235-8.
Kheder S. Cephalosporins usage and resistance trend in a sudanese hospital surgical wards. J Pharm Biomed Sci 2011;11(3):1-6.
Deshmukh VS, Khadke VV, Patil AW, Lohar PS. Study of prescribing pattern of antimicrobial agents in indoor patients of a tertiary care hospital. Int J Basic Clin Pharmacol 2013;2(3):229-36.
Patil S, Padma L, Veena DR, Shanmukananda P. Drug utilization study of antimicrobials in post-operative wards in a teaching hospital. Int Res J Pharm Appl Sci 2012;2(5):56-9.
Zaidi S, Nishtar NA. Rational prescription and use: A snapshot of the evidence from Pakistan and emerging concerns. Int J Pharm Pharm Sci 2013;5(1):131-5.
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