PHENETHYL ALCOHOL IS AN EFFECTIVE NON-TRADITIONAL PRESERVATIVE AGENT FOR COSMETIC PREPARATIONS

Sasithorn Sirilun; Chaiyavat Chaiyasut; Bhagavathi Sundaram Sivamaruthi; Sartjin Peerajan; Naphatsorn Kumar; PERIYANAINA KESIKA

doi:10.22159/ajpcr.2017.v10i8.18572

Authors

Sasithorn Sirilun Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai-50200, Thailand
Chaiyavat Chaiyasut Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai-50200, Thailand
Bhagavathi Sundaram Sivamaruthi Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai-50200, Thailand
Sartjin Peerajan Health Innovation Institute, Chiang Mai-50200, Thailand.
Naphatsorn Kumar School of Cosmetic Science, Mae Fah Luang University, Chiang Rai-57100, Thailand
PERIYANAINA KESIKA Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai -50200 http://orcid.org/0000-0002-3342-0947

DOI:

https://doi.org/10.22159/ajpcr.2017.v10i8.18572

Keywords:

Cosmetic, Phenethyl alcohol, Preservative, Self-preserving cosmetic

Abstract

Objective: Preservatives are used in the cosmetic products to protect the potential growth of microbes, therefore to prolong the shelf-life of products and to protect the consumer from infections. However several preservatives can cause various health problems, and the safety profiles of those preservatives are still unclear. Many natural substances are used in the cosmetic products to substitute the traditional preservatives. The present study deals with the evaluation of conservative nature of phenethyl alcohol (PEA) in three cosmetic formulations (emulsion, cleansing, and conditioner).

Methods: Three different concentration of PEA (0.3, 1, and 2.5 %) were used in cosmetic formulations. The physical appearance of the formulas was assessed manually, and the antimicrobial nature of PEA and PEA-containing cosmetic formulations were evaluated by agar well plate assay.

Results: The use of PEA has not affected the physical appearance, and quality of the formulations, except the high concentration of PEA in the cleansing solution, which reduced the foam formation. The minimal required concentration of PEA in emulsions and cleansings were 1.0% and 2.5% in the conditioners. All cosmetic preparations were subjected to antibacterial and antifungal evaluation. The alkaline pH (> 8) affected the antimicrobial activity of PEA in a cosmetic product.

Conclusion: The results suggested that PEA is a potent non-traditional preservative for the cosmetic formulations especially in the emulsion, cleansing solutions, and conditioners.

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