EFFECTS OF A PROPRIETARY BLEND RICH IN GLYCOSIDE BASED STANDARDIZED FENUGREEK SEED EXTRACT (IBPR) ON INFLAMMATORY MARKERS DURING ACUTE ECCENTRIC RESISTANCE EXERCISE IN YOUNG SUBJECTS

Colin Wilborn; Sara Hayward; Lem Taylor; Stacie Urbina; Cliffa Foster; Pallavi Deshpande; Vishwaraman Mohan; Prasad Thakurdesai

doi:10.22159/ajpcr.2017.v10i10.18811

Authors

Colin Wilborn University of Mary Hardin-Baylor, Human Performance Lab, Belton, TX, USA
Sara Hayward University of Mary Hardin-Baylor, Human Performance Lab, Belton, TX, USA
Lem Taylor University of Mary Hardin-Baylor, Human Performance Lab, Belton, TX, USA
Stacie Urbina A team member from study center in USA.
Cliffa Foster University of Mary Hardin-Baylor, Human Performance Lab, Belton, TX, USA
Pallavi Deshpande Department of scientific affairs, Indus Biotech Private Limited, 1, Rahul Residency, Off Salunke Vihar Road, Kondhwa, Pune-411 048, India
Vishwaraman Mohan Department of scientific affairs, Indus Biotech Private Limited, 1, Rahul Residency, Off Salunke Vihar Road, Kondhwa, Pune-411 048, India
Prasad Thakurdesai Department of scientific affairs, Indus Biotech Private Limited, 1, Rahul Residency, Off Salunke Vihar Road, Kondhwa, Pune-411 048, India

DOI:

https://doi.org/10.22159/ajpcr.2017.v10i10.18811

Keywords:

Fenugreek glycosides, Inflammation markers, Eccentric exercise

Abstract

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Â Objective: To assess the efficacy of a proprietary blend rich in glycoside based standardized fenugreek seed extract (400 mg) and minor quantities of curcumin and cinnamon (25 mg each) supplementation (IBPR) on inflammatory markers related to skeletal muscle soreness using double-blind placebo control, parallel design.

Methods: A total of 20 healthy non-resistance trained young male and female subjects were assigned to ingest either IBPR or matching placebo for 14 days before the eccentric exercise bout. Subjects were instructed to perform 24 sets with 10 eccentric knee extensor repetitions (with one leg at 30Â°/s on an isokinetic device). Subjects had their blood drawn at baseline, immediately post, 1 hr, 3 hrs, and 24 hrs post-eccentric exercise. Efficacy in terms of serum levels of anti-inflammatory cytokines interleukin-10 (IL-10), pro-inflammatory cytokines (IL-1ra, IL-1b, IL-6, and tumor necrosis factor) and safety in terms of kidney function (blood urea nitrogen (BUN), serum creatinine, BUN to creatinine ratio), and differential leukocyte count were measured. The data of each parameter were analyzed by two-way repeated measure ANOVA.

Results: Significant time-dependent effects were observed in IL1b, IL6, and creatinine values from baseline whereas significant treatment dependent effect was seen in IL-1ra. IBPR was found to be safe and well tolerated.

Conclusion: IBPR supplementation showed a significant anti-inflammatory efficacy on eccentric exercise-induced inflammatory markers of skeletal muscle soreness in non-resistance trained subjects.

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