Spectroscopic Investigation for Photo stability of Hydrochlorothiazide Complexes with β-Cyclodextrin and HPMC.
DOI:
https://doi.org/10.22159/ajpcr.2017.v10i7.18874Keywords:
Pharmaceutical analysisAbstract
Hydrochlorothiazide (HCT) is a poorly water-soluble drug. The aim of this study was to determine whether inclusion complexes between β-cyclodextrin and HCT are formed and also studied effect of auxiliary substance (HPMC) on HCT, photo-stability of HCT and to characterize these. Equimolar HCT/ βCD solid systems in the presence or absence of 0.2% (w/v) of HPMC were prepared by kneading method. The systems were characterized by phase solubility, Dissolution study, FTIR, DSC and the photo-stability test followed by u.v. spectroscopy.  The results suggest that true binary and ternary inclusion complex. The test results have proved that the complexed HCT with hydroxypropyl β- cyclodextrin enhance the photo degradation rate and resolute the optimal molar ratio HCT to hydroxypropyl β- cyclodextrin as 1:1.
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