FORMULATION OF NANOPARTICLES OF TELMISARTAN INCORPORATED IN CARBOXYMETHYLCHITOSAN FOR THE BETTER DRUG DELIVERY AND ENHANCED BIOAVAILABILITY

Upasana Yadav; Angshuman Ray Chowdhuri; Sumanta Kumar Sahu; Nuzhat Husain; Qamar Rehman

doi:10.22159/ajpcr.2017.v10i9.19162

Authors

Upasana Yadav Department of Biotechnology, School of Applied Sciences, Amity University, Lucknow, Uttar Pradesh, India.
Angshuman Ray Chowdhuri Department of Applied Chemistry, Indian School of Mines, Dhanbad, Jharkhand, India.
Sumanta Kumar Sahu Department of Applied Chemistry, Indian School of Mines, Dhanbad, Jharkhand, India.
Nuzhat Husain 4Department of Biotechnology, Amity University, Lucknow, Uttar Pradesh, India.
Qamar Rehman Department of Pathology, Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

DOI:

https://doi.org/10.22159/ajpcr.2017.v10i9.19162

Keywords:

Telmisartan, Nanoparticle, Carboxymethyl chitosan, Transmission electron microscopy, Scanning electron microscopy

Abstract

Â

Â Objective: In this study, we have made an attempt to the developed formulation of nanoparticles (NPs) of telmisartan (TLM) incorporated in carboxymethyl chitosan (CMCS) for the better drug delivery and enhanced bioavailability.

Materials and Methods: The NPs size and morphology were investigated by high-resolution transmission electron microscopy and field emission scanning electron microscopy, respectively. The crystal structures and surface functional groups were analyzed using X-ray diffraction pattern, and Fourier transform infrared spectroscopy, respectively.

Results: To increase the solubility of TLM by targeted delivery of the drug through polymeric NPs is an alternative efficient, option for increasing the solubility. TLM nanosuspension powders were successfully formulated for dissolution and bioavailability enhancement of the drug. We focused on evaluating the influence of particle size and crystalline state on the in vitro and in vivo performance of TLM.

Conclusion: In summary, we have developed a new approach toward the delivery of poorly water-soluble drug TLM by CMCS NPs. The particles having a good drug loading content and drug encapsulation efficiency. The cytotoxicity of the synthesized NPs is also very less.

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